Targeting the MEK1/2 pathway to combat Staphylococcus aureus infection and inflammation in cystic fibrosis

Targeting the MEK1/2 pathway to combat Staphylococcus aureus infection and inflammation in cystic fibrosis

ABSTRACT Staphylococcus aureus infections remain an ongoing challenge for people with cystic fibrosis (PwCF), with the increased global prevalence of multidrug-resistant strains requiring new therapeutic approaches. Our previous studies demonstrated anti-inflammatory effects of several MEK1/2 inhibi...

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Bibliographic Details
Main Authors: Eryn Zuiker, Gregory Serpa, Mithu De, Yiwei Liu, Daniel J. Wozniak, Kymberly M. Gowdy, Jean Charron, Susan E. Birket, Megan R. Kiedrowski, Emily A. Hemann, Matthew E. Long
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mBio
Subjects:
Staphylococcus aureus
cystic fibrosis
macrophages
MEK1/2
Online Access:https://journals.asm.org/doi/10.1128/mbio.00775-25
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