IRON DEFICIENCY ANAEMIA AMONG PRE-SCHOOL CHILDREN WITH SICKLE CELL ANAEMIA: STILL A RARE DIAGNOSIS?
Background: The frequent need for blood transfusion in children with SCA creates the impression that IDA is rare in this class of children. Objectives: The objective of the study is to determine the prevalence of IDA in a population of under-five children with SCA in Lagos, Nigeria. Methodology:...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2013-11-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/459 |
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| author | Olufemi Samuel Akodu Omolara Adeolu Kehinde Ijeoma Nnena Diaku-Akinwumi Olisamedua Fidelis Njokanma |
| author_facet | Olufemi Samuel Akodu Omolara Adeolu Kehinde Ijeoma Nnena Diaku-Akinwumi Olisamedua Fidelis Njokanma |
| author_sort | Olufemi Samuel Akodu |
| collection | DOAJ |
| description | Background: The frequent need for blood transfusion in children with SCA creates the impression that IDA is rare in this class of children.
Objectives: The objective of the study is to determine the prevalence of IDA in a population of under-five children with SCA in Lagos, Nigeria.
Methodology: Serum iron, total iron binding capacity, transferrin saturation and serum ferritin were assayed in 97 under-five children with SCA and 97 age/sex matched controls.
The diagnosis of IDA was established based on the following criteria: haemoglobin <11.0 g/dl plus two or more of the following: MCV <70fl, transferrin saturation (Ts) <16% or serum ferritin (SF) <25ng/dL
Results: Overall prevalence of IDA was significantly higher among AA controls. In the younger age group, the prevalence of IDA was significantly higher among HbAA controls while in the older age group the odds of having IDA was three times higher among HbSS subjects but the difference was not statistically significant. Two of the three SCA children with IDA have history of previous blood transfusion.
Conclusion: IDA is uncommon in pre-school aged children with SCA. A multi-centre study is necessary to yield large number of transfused subjects to examine the effects of blood transfusion on prevalence of IDA. |
| format | Article |
| id | doaj-art-c726e2dd97924cd39d31e353e5038df3 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2013-11-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-c726e2dd97924cd39d31e353e5038df32025-01-02T01:57:48ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062013-11-0151e2013069e201306910.4084/mjhid.2013.069351IRON DEFICIENCY ANAEMIA AMONG PRE-SCHOOL CHILDREN WITH SICKLE CELL ANAEMIA: STILL A RARE DIAGNOSIS?Olufemi Samuel Akodu0Omolara Adeolu KehindeIjeoma Nnena Diaku-AkinwumiOlisamedua Fidelis NjokanmaLagos State University Teaching HospitalBackground: The frequent need for blood transfusion in children with SCA creates the impression that IDA is rare in this class of children. Objectives: The objective of the study is to determine the prevalence of IDA in a population of under-five children with SCA in Lagos, Nigeria. Methodology: Serum iron, total iron binding capacity, transferrin saturation and serum ferritin were assayed in 97 under-five children with SCA and 97 age/sex matched controls. The diagnosis of IDA was established based on the following criteria: haemoglobin <11.0 g/dl plus two or more of the following: MCV <70fl, transferrin saturation (Ts) <16% or serum ferritin (SF) <25ng/dL Results: Overall prevalence of IDA was significantly higher among AA controls. In the younger age group, the prevalence of IDA was significantly higher among HbAA controls while in the older age group the odds of having IDA was three times higher among HbSS subjects but the difference was not statistically significant. Two of the three SCA children with IDA have history of previous blood transfusion. Conclusion: IDA is uncommon in pre-school aged children with SCA. A multi-centre study is necessary to yield large number of transfused subjects to examine the effects of blood transfusion on prevalence of IDA.http://www.mjhid.org/index.php/mjhid/article/view/459iron deficiency anaemia, iron depletion, iron deficiency, sickle cell anaemia |
| spellingShingle | Olufemi Samuel Akodu Omolara Adeolu Kehinde Ijeoma Nnena Diaku-Akinwumi Olisamedua Fidelis Njokanma IRON DEFICIENCY ANAEMIA AMONG PRE-SCHOOL CHILDREN WITH SICKLE CELL ANAEMIA: STILL A RARE DIAGNOSIS? Mediterranean Journal of Hematology and Infectious Diseases iron deficiency anaemia, iron depletion, iron deficiency, sickle cell anaemia |
| title | IRON DEFICIENCY ANAEMIA AMONG PRE-SCHOOL CHILDREN WITH SICKLE CELL ANAEMIA: STILL A RARE DIAGNOSIS? |
| title_full | IRON DEFICIENCY ANAEMIA AMONG PRE-SCHOOL CHILDREN WITH SICKLE CELL ANAEMIA: STILL A RARE DIAGNOSIS? |
| title_fullStr | IRON DEFICIENCY ANAEMIA AMONG PRE-SCHOOL CHILDREN WITH SICKLE CELL ANAEMIA: STILL A RARE DIAGNOSIS? |
| title_full_unstemmed | IRON DEFICIENCY ANAEMIA AMONG PRE-SCHOOL CHILDREN WITH SICKLE CELL ANAEMIA: STILL A RARE DIAGNOSIS? |
| title_short | IRON DEFICIENCY ANAEMIA AMONG PRE-SCHOOL CHILDREN WITH SICKLE CELL ANAEMIA: STILL A RARE DIAGNOSIS? |
| title_sort | iron deficiency anaemia among pre school children with sickle cell anaemia still a rare diagnosis |
| topic | iron deficiency anaemia, iron depletion, iron deficiency, sickle cell anaemia |
| url | http://www.mjhid.org/index.php/mjhid/article/view/459 |
| work_keys_str_mv | AT olufemisamuelakodu irondeficiencyanaemiaamongpreschoolchildrenwithsicklecellanaemiastillararediagnosis AT omolaraadeolukehinde irondeficiencyanaemiaamongpreschoolchildrenwithsicklecellanaemiastillararediagnosis AT ijeomannenadiakuakinwumi irondeficiencyanaemiaamongpreschoolchildrenwithsicklecellanaemiastillararediagnosis AT olisameduafidelisnjokanma irondeficiencyanaemiaamongpreschoolchildrenwithsicklecellanaemiastillararediagnosis |