Evaluation of Clavulanic Acid Adsorption in MgAl-Layered Double Hydroxides: Kinetic, Equilibrium and Thermodynamic Studies
Kinetics, equilibrium and thermodynamic studies of clavulanic acid adsorption onto hydrotalcites have been conducted with the aim of selecting the best conditions for biomolecular separation. For this purpose, hydrotalcites of different compositions (containing 30, 63 and 70% MgO in their compositio...
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SAGE Publishing
2012-01-01
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| Series: | Adsorption Science & Technology |
| Online Access: | https://doi.org/10.1260/0263-6174.30.1.65 |
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| author | Marcus Bruno Soares Forte Élen Cristina Luna Elias Heloise O. Pastore Francisco Maugeri Filho Maria Isabel Rodrigues |
| author_facet | Marcus Bruno Soares Forte Élen Cristina Luna Elias Heloise O. Pastore Francisco Maugeri Filho Maria Isabel Rodrigues |
| author_sort | Marcus Bruno Soares Forte |
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| description | Kinetics, equilibrium and thermodynamic studies of clavulanic acid adsorption onto hydrotalcites have been conducted with the aim of selecting the best conditions for biomolecular separation. For this purpose, hydrotalcites of different compositions (containing 30, 63 and 70% MgO in their compositions) were tested, with and without pre-treatment (uncalcined and calcined). A model was obtained to predict the degradation constant. This model may be useful in predicting the extent of clavulanic acid hydrolysis in the adsorption process. Adsorption studies were performed in stirred batch glass reactors. Assays were performed using solutions under different conditions, as well as variable solid/liquid ratios. It was shown that distilled water and a solid/liquid ratio of 15.0 mg/ℓ generated the most favourable conditions for adsorption. A calcined hydrotalcite containing 70% MgO was selected for further study since it presented the best adsorption performance. The adsorbents were characterized by X-ray diffraction methods, Fourier-transform infrared spectroscopy and scanning electron microscopy. Adsorption equilibrium was evaluated from adsorption isotherms determined at different temperatures. The experimental isotherm data were well fitted by a linear equilibrium model with the corresponding adsorption constants being K = 0.404, 0.602, 0.849 and 1.083 ℓ/g at 16.5, 19.0, 21.5 and 24.0 °C, respectively, showing an increased adsorption capacity at higher temperatures. Thermodynamic evaluation of the process allowed the Gibbs' free energy (ΔG 0 ), the standard enthalpy change (ΔH 0 ) and the standard entropy change (ΔS 0 ) to be estimated as follows: ΔG 0 = 2.100, 1.301, 0.503 and −0.295 kJ/mol at 16.5, 19.0, 21.5 and 24.0 °C, respectively; ΔH 0 = 94.602 kJ/mol; and ΔS 0 = 0.319 kJ/(mol K), respectively. The positive value of ΔH 0 confirmed the endothermic nature of clavulanic acid adsorption onto HT70c hydrotalcites, which was considered to be mass transport reaction-controlled process. |
| format | Article |
| id | doaj-art-c722b868eb794041944e1461e4abb9fe |
| institution | Kabale University |
| issn | 0263-6174 2048-4038 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | SAGE Publishing |
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| series | Adsorption Science & Technology |
| spelling | doaj-art-c722b868eb794041944e1461e4abb9fe2025-01-03T00:10:25ZengSAGE PublishingAdsorption Science & Technology0263-61742048-40382012-01-013010.1260/0263-6174.30.1.65Evaluation of Clavulanic Acid Adsorption in MgAl-Layered Double Hydroxides: Kinetic, Equilibrium and Thermodynamic StudiesMarcus Bruno Soares Forte0Élen Cristina Luna Elias1Heloise O. Pastore2Francisco Maugeri Filho3Maria Isabel Rodrigues4 Laboratory of Bioprocess Engineering, Food Engineering Department, Faculty of Food Engineering, University of Campinas (UNICAMP), R. Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, Campinas SP, Brazil, 13083-862 Laboratory of Bioprocess Engineering, Food Engineering Department, Faculty of Food Engineering, University of Campinas (UNICAMP), R. Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, Campinas SP, Brazil, 13083-862 Micro and Mesoporous Molecular Sieves Group, Institute of Chemistry, University of Campinas (UNICAMP), P.O. Box 6154, Campinas-SP, Brazil, 13083-970 Laboratory of Bioprocess Engineering, Food Engineering Department, Faculty of Food Engineering, University of Campinas (UNICAMP), R. Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, Campinas SP, Brazil, 13083-862 Laboratory of Bioprocess Engineering, Food Engineering Department, Faculty of Food Engineering, University of Campinas (UNICAMP), R. Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, Campinas SP, Brazil, 13083-862Kinetics, equilibrium and thermodynamic studies of clavulanic acid adsorption onto hydrotalcites have been conducted with the aim of selecting the best conditions for biomolecular separation. For this purpose, hydrotalcites of different compositions (containing 30, 63 and 70% MgO in their compositions) were tested, with and without pre-treatment (uncalcined and calcined). A model was obtained to predict the degradation constant. This model may be useful in predicting the extent of clavulanic acid hydrolysis in the adsorption process. Adsorption studies were performed in stirred batch glass reactors. Assays were performed using solutions under different conditions, as well as variable solid/liquid ratios. It was shown that distilled water and a solid/liquid ratio of 15.0 mg/ℓ generated the most favourable conditions for adsorption. A calcined hydrotalcite containing 70% MgO was selected for further study since it presented the best adsorption performance. The adsorbents were characterized by X-ray diffraction methods, Fourier-transform infrared spectroscopy and scanning electron microscopy. Adsorption equilibrium was evaluated from adsorption isotherms determined at different temperatures. The experimental isotherm data were well fitted by a linear equilibrium model with the corresponding adsorption constants being K = 0.404, 0.602, 0.849 and 1.083 ℓ/g at 16.5, 19.0, 21.5 and 24.0 °C, respectively, showing an increased adsorption capacity at higher temperatures. Thermodynamic evaluation of the process allowed the Gibbs' free energy (ΔG 0 ), the standard enthalpy change (ΔH 0 ) and the standard entropy change (ΔS 0 ) to be estimated as follows: ΔG 0 = 2.100, 1.301, 0.503 and −0.295 kJ/mol at 16.5, 19.0, 21.5 and 24.0 °C, respectively; ΔH 0 = 94.602 kJ/mol; and ΔS 0 = 0.319 kJ/(mol K), respectively. The positive value of ΔH 0 confirmed the endothermic nature of clavulanic acid adsorption onto HT70c hydrotalcites, which was considered to be mass transport reaction-controlled process.https://doi.org/10.1260/0263-6174.30.1.65 |
| spellingShingle | Marcus Bruno Soares Forte Élen Cristina Luna Elias Heloise O. Pastore Francisco Maugeri Filho Maria Isabel Rodrigues Evaluation of Clavulanic Acid Adsorption in MgAl-Layered Double Hydroxides: Kinetic, Equilibrium and Thermodynamic Studies Adsorption Science & Technology |
| title | Evaluation of Clavulanic Acid Adsorption in MgAl-Layered Double Hydroxides: Kinetic, Equilibrium and Thermodynamic Studies |
| title_full | Evaluation of Clavulanic Acid Adsorption in MgAl-Layered Double Hydroxides: Kinetic, Equilibrium and Thermodynamic Studies |
| title_fullStr | Evaluation of Clavulanic Acid Adsorption in MgAl-Layered Double Hydroxides: Kinetic, Equilibrium and Thermodynamic Studies |
| title_full_unstemmed | Evaluation of Clavulanic Acid Adsorption in MgAl-Layered Double Hydroxides: Kinetic, Equilibrium and Thermodynamic Studies |
| title_short | Evaluation of Clavulanic Acid Adsorption in MgAl-Layered Double Hydroxides: Kinetic, Equilibrium and Thermodynamic Studies |
| title_sort | evaluation of clavulanic acid adsorption in mgal layered double hydroxides kinetic equilibrium and thermodynamic studies |
| url | https://doi.org/10.1260/0263-6174.30.1.65 |
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