Alginate–Poly[2-(methacryloyloxy)ethyl]trimethylammonium Chloride (PMETAC) Immunoisolating Capsules Prolong the Viability of Pancreatic Islets In Vivo
Background/Objectives: This study focuses on the development and evaluation of novel alginate–poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride (PMETAC) microcapsules for encapsulating pancreatic islets to address insulin deficiency in diabetes. Methods: In previous research, we fabricated an...
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MDPI AG
2024-11-01
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| Online Access: | https://www.mdpi.com/2227-9059/12/11/2573 |
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| author | Polina Ermakova Ekaterina Vasilchikova Arseniy Potapov Maxim Baten’kin Liya Lugovaya Alexandra Bogomolova Julia Tselousova Alexey Konev Natalia Anisimova Alena Egoshina Mariya Zakharina Nasipbek Naraliev Denis Kuchin Vladimir Zagainov Sergey Chesnokov Aleksandra Kashina Elena Zagaynova |
| author_facet | Polina Ermakova Ekaterina Vasilchikova Arseniy Potapov Maxim Baten’kin Liya Lugovaya Alexandra Bogomolova Julia Tselousova Alexey Konev Natalia Anisimova Alena Egoshina Mariya Zakharina Nasipbek Naraliev Denis Kuchin Vladimir Zagainov Sergey Chesnokov Aleksandra Kashina Elena Zagaynova |
| author_sort | Polina Ermakova |
| collection | DOAJ |
| description | Background/Objectives: This study focuses on the development and evaluation of novel alginate–poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride (PMETAC) microcapsules for encapsulating pancreatic islets to address insulin deficiency in diabetes. Methods: In previous research, we fabricated and characterized PMETAC microcapsules, evaluating their stability and permeability in vitro. This study further probes the capsules in vivo, focusing on the functional activity of the encapsulated islets post-transplantation, their viability extension, and the assessment of the immunoprotective, antifibrotic properties, and biostability of the capsules. Results: Rabbit-derived islets were encapsulated and transplanted into diabetic rats. The encapsulated islets maintained insulin secretion for up to 90 days, significantly longer than non-encapsulated ones, which ceased functioning after 7 days. Histological analysis demonstrated high biocompatibility of the PMETAC coating, resulting in minimal fibrotic overgrowth around the capsules. Conclusions: The study highlights the critical role of immunoprotection and the tendency to reduce fibrosis in prolonging islet function. These findings suggest that PMETAC-coated capsules offer a promising solution for cell-based therapies in diabetes by improving graft longevity and reducing fibrotic overgrowth. |
| format | Article |
| id | doaj-art-c7192e06bff545baa5785f7d5bc630c2 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-c7192e06bff545baa5785f7d5bc630c22024-11-26T17:53:17ZengMDPI AGBiomedicines2227-90592024-11-011211257310.3390/biomedicines12112573Alginate–Poly[2-(methacryloyloxy)ethyl]trimethylammonium Chloride (PMETAC) Immunoisolating Capsules Prolong the Viability of Pancreatic Islets In VivoPolina Ermakova0Ekaterina Vasilchikova1Arseniy Potapov2Maxim Baten’kin3Liya Lugovaya4Alexandra Bogomolova5Julia Tselousova6Alexey Konev7Natalia Anisimova8Alena Egoshina9Mariya Zakharina10Nasipbek Naraliev11Denis Kuchin12Vladimir Zagainov13Sergey Chesnokov14Aleksandra Kashina15Elena Zagaynova16Federal State Budgetary Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of Russia, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of Russia, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of Russia, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Science Institute of Organometallic Chemistry Them G.A. Razuvaev Russian Academy of Sciences, 603950 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of Russia, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of Russia, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of Russia, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Science Institute of Organometallic Chemistry Them G.A. Razuvaev Russian Academy of Sciences, 603950 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Science Institute of Organometallic Chemistry Them G.A. Razuvaev Russian Academy of Sciences, 603950 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Science Institute of Organometallic Chemistry Them G.A. Razuvaev Russian Academy of Sciences, 603950 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Science Institute of Organometallic Chemistry Them G.A. Razuvaev Russian Academy of Sciences, 603950 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of Russia, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of Russia, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of Russia, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Science Institute of Organometallic Chemistry Them G.A. Razuvaev Russian Academy of Sciences, 603950 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of Russia, 603005 Nizhny Novgorod, RussiaFederal State Budgetary Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of Russia, 603005 Nizhny Novgorod, RussiaBackground/Objectives: This study focuses on the development and evaluation of novel alginate–poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride (PMETAC) microcapsules for encapsulating pancreatic islets to address insulin deficiency in diabetes. Methods: In previous research, we fabricated and characterized PMETAC microcapsules, evaluating their stability and permeability in vitro. This study further probes the capsules in vivo, focusing on the functional activity of the encapsulated islets post-transplantation, their viability extension, and the assessment of the immunoprotective, antifibrotic properties, and biostability of the capsules. Results: Rabbit-derived islets were encapsulated and transplanted into diabetic rats. The encapsulated islets maintained insulin secretion for up to 90 days, significantly longer than non-encapsulated ones, which ceased functioning after 7 days. Histological analysis demonstrated high biocompatibility of the PMETAC coating, resulting in minimal fibrotic overgrowth around the capsules. Conclusions: The study highlights the critical role of immunoprotection and the tendency to reduce fibrosis in prolonging islet function. These findings suggest that PMETAC-coated capsules offer a promising solution for cell-based therapies in diabetes by improving graft longevity and reducing fibrotic overgrowth.https://www.mdpi.com/2227-9059/12/11/2573microcapsulesmicroencapsulationalginateislet of Langerhans |
| spellingShingle | Polina Ermakova Ekaterina Vasilchikova Arseniy Potapov Maxim Baten’kin Liya Lugovaya Alexandra Bogomolova Julia Tselousova Alexey Konev Natalia Anisimova Alena Egoshina Mariya Zakharina Nasipbek Naraliev Denis Kuchin Vladimir Zagainov Sergey Chesnokov Aleksandra Kashina Elena Zagaynova Alginate–Poly[2-(methacryloyloxy)ethyl]trimethylammonium Chloride (PMETAC) Immunoisolating Capsules Prolong the Viability of Pancreatic Islets In Vivo Biomedicines microcapsules microencapsulation alginate islet of Langerhans |
| title | Alginate–Poly[2-(methacryloyloxy)ethyl]trimethylammonium Chloride (PMETAC) Immunoisolating Capsules Prolong the Viability of Pancreatic Islets In Vivo |
| title_full | Alginate–Poly[2-(methacryloyloxy)ethyl]trimethylammonium Chloride (PMETAC) Immunoisolating Capsules Prolong the Viability of Pancreatic Islets In Vivo |
| title_fullStr | Alginate–Poly[2-(methacryloyloxy)ethyl]trimethylammonium Chloride (PMETAC) Immunoisolating Capsules Prolong the Viability of Pancreatic Islets In Vivo |
| title_full_unstemmed | Alginate–Poly[2-(methacryloyloxy)ethyl]trimethylammonium Chloride (PMETAC) Immunoisolating Capsules Prolong the Viability of Pancreatic Islets In Vivo |
| title_short | Alginate–Poly[2-(methacryloyloxy)ethyl]trimethylammonium Chloride (PMETAC) Immunoisolating Capsules Prolong the Viability of Pancreatic Islets In Vivo |
| title_sort | alginate poly 2 methacryloyloxy ethyl trimethylammonium chloride pmetac immunoisolating capsules prolong the viability of pancreatic islets in vivo |
| topic | microcapsules microencapsulation alginate islet of Langerhans |
| url | https://www.mdpi.com/2227-9059/12/11/2573 |
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