Predictive Value of Multiparametric Magnetic Resonance Imaging (T2-weighted Imaging and Apparent Diffusion Coefficient) for Pathological Grading of Prostate Cancer: a Meta-Analysis
ABSTRACT Objective: This meta-analysis aimed to evaluate the predictive value of multiparametric magnetic resonance imaging (mpMRI), specifically T2-weighted imaging (T2WI) and apparent diffusion coefficient (ADC) maps, in the pathological grading of prostate cancer. Methods: A comprehensive liter...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2025-04-01
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| Series: | International Brazilian Journal of Urology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382025000300301&lng=en&tlng=en |
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| author | Subo Zhang Jinxin Wan Yongjun Xu Leiming Huo Lei Xu Jiabao Xia Zhitao Zhu Jingfang Liu Yan Zhao |
| author_facet | Subo Zhang Jinxin Wan Yongjun Xu Leiming Huo Lei Xu Jiabao Xia Zhitao Zhu Jingfang Liu Yan Zhao |
| author_sort | Subo Zhang |
| collection | DOAJ |
| description | ABSTRACT Objective: This meta-analysis aimed to evaluate the predictive value of multiparametric magnetic resonance imaging (mpMRI), specifically T2-weighted imaging (T2WI) and apparent diffusion coefficient (ADC) maps, in the pathological grading of prostate cancer. Methods: A comprehensive literature search was conducted across multiple databases, including PubMed, the China National Knowledge Infrastructure dataset, Web of Science, Springer Link and Cochrane Library. Studies evaluating the use of mpMRI for prostate cancer grading were included. The quality of the included studies was assessed using the risk of bias tool. Meta-analyses were performed to calculate pooled areas under the curve (AUC) and prostate cancer detection rates. Results: Seven studies met the inclusion criteria, comprising 843 patients in the experimental group and 962 in the control group. The meta-analysis revealed a significant improvement in diagnostic performance with mpMRI, with a pooled mean difference in AUC of 0.10 (95% confidence interval [CI]: 0.04–0.16, p = 0.002) favouring the mpMRI group. The odds ratio for prostate cancer detection was 2.60 (95% CI: 1.57–4.29, p = 0.0002), indicating a higher detection rate with mpMRI compared with standard techniques. Substantial heterogeneity was observed among the studies (I² = 73% for AUC and 66% for detection rate). Conclusion: This meta-analysis demonstrates that mpMRI, particularly T2WI and ADC imaging, has a significant predictive value in the pathological grading of prostate cancer. The technique shows improved diagnostic accuracy and higher cancer detection rates compared with conventional methods. However, the substantial heterogeneity among studies suggests that standardisation of mpMRI protocols and interpretation criteria is needed. |
| format | Article |
| id | doaj-art-c7174c9e5cf64feaac6f4d43f7e6819c |
| institution | Kabale University |
| issn | 1677-6119 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj-art-c7174c9e5cf64feaac6f4d43f7e6819c2025-08-20T03:52:14ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-61192025-04-0151310.1590/s1677-5538.ibju.2024.0509Predictive Value of Multiparametric Magnetic Resonance Imaging (T2-weighted Imaging and Apparent Diffusion Coefficient) for Pathological Grading of Prostate Cancer: a Meta-AnalysisSubo ZhangJinxin WanYongjun XuLeiming HuoLei XuJiabao XiaZhitao ZhuJingfang LiuYan Zhaohttps://orcid.org/0009-0007-3881-3962ABSTRACT Objective: This meta-analysis aimed to evaluate the predictive value of multiparametric magnetic resonance imaging (mpMRI), specifically T2-weighted imaging (T2WI) and apparent diffusion coefficient (ADC) maps, in the pathological grading of prostate cancer. Methods: A comprehensive literature search was conducted across multiple databases, including PubMed, the China National Knowledge Infrastructure dataset, Web of Science, Springer Link and Cochrane Library. Studies evaluating the use of mpMRI for prostate cancer grading were included. The quality of the included studies was assessed using the risk of bias tool. Meta-analyses were performed to calculate pooled areas under the curve (AUC) and prostate cancer detection rates. Results: Seven studies met the inclusion criteria, comprising 843 patients in the experimental group and 962 in the control group. The meta-analysis revealed a significant improvement in diagnostic performance with mpMRI, with a pooled mean difference in AUC of 0.10 (95% confidence interval [CI]: 0.04–0.16, p = 0.002) favouring the mpMRI group. The odds ratio for prostate cancer detection was 2.60 (95% CI: 1.57–4.29, p = 0.0002), indicating a higher detection rate with mpMRI compared with standard techniques. Substantial heterogeneity was observed among the studies (I² = 73% for AUC and 66% for detection rate). Conclusion: This meta-analysis demonstrates that mpMRI, particularly T2WI and ADC imaging, has a significant predictive value in the pathological grading of prostate cancer. The technique shows improved diagnostic accuracy and higher cancer detection rates compared with conventional methods. However, the substantial heterogeneity among studies suggests that standardisation of mpMRI protocols and interpretation criteria is needed.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382025000300301&lng=en&tlng=enProstatic NeoplasmsMultiparametric Magnetic Resonance ImagingMeta-Analysis [Publication Type] |
| spellingShingle | Subo Zhang Jinxin Wan Yongjun Xu Leiming Huo Lei Xu Jiabao Xia Zhitao Zhu Jingfang Liu Yan Zhao Predictive Value of Multiparametric Magnetic Resonance Imaging (T2-weighted Imaging and Apparent Diffusion Coefficient) for Pathological Grading of Prostate Cancer: a Meta-Analysis International Brazilian Journal of Urology Prostatic Neoplasms Multiparametric Magnetic Resonance Imaging Meta-Analysis [Publication Type] |
| title | Predictive Value of Multiparametric Magnetic Resonance Imaging (T2-weighted Imaging and Apparent Diffusion Coefficient) for Pathological Grading of Prostate Cancer: a Meta-Analysis |
| title_full | Predictive Value of Multiparametric Magnetic Resonance Imaging (T2-weighted Imaging and Apparent Diffusion Coefficient) for Pathological Grading of Prostate Cancer: a Meta-Analysis |
| title_fullStr | Predictive Value of Multiparametric Magnetic Resonance Imaging (T2-weighted Imaging and Apparent Diffusion Coefficient) for Pathological Grading of Prostate Cancer: a Meta-Analysis |
| title_full_unstemmed | Predictive Value of Multiparametric Magnetic Resonance Imaging (T2-weighted Imaging and Apparent Diffusion Coefficient) for Pathological Grading of Prostate Cancer: a Meta-Analysis |
| title_short | Predictive Value of Multiparametric Magnetic Resonance Imaging (T2-weighted Imaging and Apparent Diffusion Coefficient) for Pathological Grading of Prostate Cancer: a Meta-Analysis |
| title_sort | predictive value of multiparametric magnetic resonance imaging t2 weighted imaging and apparent diffusion coefficient for pathological grading of prostate cancer a meta analysis |
| topic | Prostatic Neoplasms Multiparametric Magnetic Resonance Imaging Meta-Analysis [Publication Type] |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382025000300301&lng=en&tlng=en |
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