Cardiomyocyte-specific Piezo1 deficiency mitigates ischemia-reperfusion injury by preserving mitochondrial homeostasis

Cardiomyocyte-specific Piezo1 deficiency mitigates ischemia-reperfusion injury by preserving mitochondrial homeostasis

Ca2+ overload and mitochondrial dysfunction play crucial roles in myocardial ischemia-reperfusion (I/R) injury. Piezo1, a mechanosensitive cation channel, is essential for intracellular Ca2+ homeostasis. The objective of this research was to explore the effects of Piezo1 on mitochondrial function du...

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Bibliographic Details
Main Authors: Honglin Xu, Xin Chen, Shangfei Luo, Jintao Jiang, Xianmei Pan, Yu He, Bo Deng, Silin Liu, Rentao Wan, Liwen Lin, Qiaorui Tan, Xiaoting Chen, Youfen Yao, Bin He, Yajuan An, Jing Li
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Redox Biology
Subjects:
I/R
Piezo1
Mitochondria
Inflammation
Calpain
Cardiomyocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172400449X
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