A novel pigeon paramyxovirus type 1 isolated from a sick racing pigeon in the Qinghai-Tibet Plateau of China shows high virulence in chickens
Pigeon paramyxovirus type-1 (PPMV-1) is the causative agent of pigeon Newcastle disease (ND), which has caused huge losses to the pigeon industry. In this study, a PPMV-1 strain, PPMV-1/QH-01/CH/23, was isolated from a sick racing pigeon in the Qinghai-Tibet Plateau, China in 2023. The mean death ti...
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Czech Academy of Agricultural Sciences
2024-11-01
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| Series: | Veterinární Medicína |
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| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-202411-0001_a-novel-pigeon-paramyxovirus-type-1-isolated-from-a-sick-racing-pigeon-in-the-qinghai-8211-tibet-plateau-of-ch.php |
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| author | L Tong X Gao L Feng D Yao X Zhang Y Du Y Zhou F Chen |
| author_facet | L Tong X Gao L Feng D Yao X Zhang Y Du Y Zhou F Chen |
| author_sort | L Tong |
| collection | DOAJ |
| description | Pigeon paramyxovirus type-1 (PPMV-1) is the causative agent of pigeon Newcastle disease (ND), which has caused huge losses to the pigeon industry. In this study, a PPMV-1 strain, PPMV-1/QH-01/CH/23, was isolated from a sick racing pigeon in the Qinghai-Tibet Plateau, China in 2023. The mean death time of chicken embryos and the intracerebral pathogenicity index (ICPI) were 76.8 h and 1.25, indicating a mesogenic strain. Pigeon morbidity and mortality were 100% and 80%, respectively, and both were 80% in chickens; therefore, this isolate was velogenic for both pigeons and chickens. The fusion gene was amplified and sequenced for phylogenetic analysis, and the results indicated that the isolated strain possessed a virulent fusion protein cleavage site motif, 112R-R-Q-K-R-F117, and belonged to genotype XX (former sub-genotype VIc) of class II; this was different from the predominant sub-genotype, VI.2.1.1.2.2, which is prevalent in pigeons. To the best of our knowledge, this is the first report of a novel genotype XX isolate possessing high virulence for both chickens and pigeons in the Qinghai-Tibet Plateau, China. |
| format | Article |
| id | doaj-art-c709506bac444f209ee531070a6ac1a3 |
| institution | Kabale University |
| issn | 0375-8427 1805-9392 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj-art-c709506bac444f209ee531070a6ac1a32024-11-29T10:19:58ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922024-11-016911389394vet-202411-0001A novel pigeon paramyxovirus type 1 isolated from a sick racing pigeon in the Qinghai-Tibet Plateau of China shows high virulence in chickensL Tong0X Gao1L Feng2D Yao3X Zhang4Y Du5Y Zhou6F Chen7College of Agriculture and Animal Husbandry, Qinghai University, Xining, P.R. ChinaCollege of Agriculture and Animal Husbandry, Qinghai University, Xining, P.R. ChinaCollege of Agriculture and Animal Husbandry, Qinghai University, Xining, P.R. ChinaCollege of Agriculture and Animal Husbandry, Qinghai University, Xining, P.R. ChinaCollege of Agriculture and Animal Husbandry, Qinghai University, Xining, P.R. ChinaCollege of Agriculture and Animal Husbandry, Qinghai University, Xining, P.R. ChinaCollege of Agriculture and Animal Husbandry, Qinghai University, Xining, P.R. ChinaCollege of Agriculture and Animal Husbandry, Qinghai University, Xining, P.R. ChinaPigeon paramyxovirus type-1 (PPMV-1) is the causative agent of pigeon Newcastle disease (ND), which has caused huge losses to the pigeon industry. In this study, a PPMV-1 strain, PPMV-1/QH-01/CH/23, was isolated from a sick racing pigeon in the Qinghai-Tibet Plateau, China in 2023. The mean death time of chicken embryos and the intracerebral pathogenicity index (ICPI) were 76.8 h and 1.25, indicating a mesogenic strain. Pigeon morbidity and mortality were 100% and 80%, respectively, and both were 80% in chickens; therefore, this isolate was velogenic for both pigeons and chickens. The fusion gene was amplified and sequenced for phylogenetic analysis, and the results indicated that the isolated strain possessed a virulent fusion protein cleavage site motif, 112R-R-Q-K-R-F117, and belonged to genotype XX (former sub-genotype VIc) of class II; this was different from the predominant sub-genotype, VI.2.1.1.2.2, which is prevalent in pigeons. To the best of our knowledge, this is the first report of a novel genotype XX isolate possessing high virulence for both chickens and pigeons in the Qinghai-Tibet Plateau, China.https://vetmed.agriculturejournals.cz/artkey/vet-202411-0001_a-novel-pigeon-paramyxovirus-type-1-isolated-from-a-sick-racing-pigeon-in-the-qinghai-8211-tibet-plateau-of-ch.phpgenotype xxppmv-1velogenic strain |
| spellingShingle | L Tong X Gao L Feng D Yao X Zhang Y Du Y Zhou F Chen A novel pigeon paramyxovirus type 1 isolated from a sick racing pigeon in the Qinghai-Tibet Plateau of China shows high virulence in chickens Veterinární Medicína genotype xx ppmv-1 velogenic strain |
| title | A novel pigeon paramyxovirus type 1 isolated from a sick racing pigeon in the Qinghai-Tibet Plateau of China shows high virulence in chickens |
| title_full | A novel pigeon paramyxovirus type 1 isolated from a sick racing pigeon in the Qinghai-Tibet Plateau of China shows high virulence in chickens |
| title_fullStr | A novel pigeon paramyxovirus type 1 isolated from a sick racing pigeon in the Qinghai-Tibet Plateau of China shows high virulence in chickens |
| title_full_unstemmed | A novel pigeon paramyxovirus type 1 isolated from a sick racing pigeon in the Qinghai-Tibet Plateau of China shows high virulence in chickens |
| title_short | A novel pigeon paramyxovirus type 1 isolated from a sick racing pigeon in the Qinghai-Tibet Plateau of China shows high virulence in chickens |
| title_sort | novel pigeon paramyxovirus type 1 isolated from a sick racing pigeon in the qinghai tibet plateau of china shows high virulence in chickens |
| topic | genotype xx ppmv-1 velogenic strain |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-202411-0001_a-novel-pigeon-paramyxovirus-type-1-isolated-from-a-sick-racing-pigeon-in-the-qinghai-8211-tibet-plateau-of-ch.php |
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