Toxicological impact of rabeprazole and evaluation of toxic effects on the plant-based eukaryotic test models
Background: Rabeprazole (RPZ), a widely used proton pump inhibitor, is known to have toxic effects on human beings. Objective: To evaluate the current understanding of its toxicological effects on humans and animals, a literature and laboratory-based study was conducted. Methods: A comprehensive...
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Universidad de Antioquia
2024-09-01
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| Series: | Vitae |
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| Online Access: | https://revistas.udea.edu.co/index.php/vitae/article/view/352429 |
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| author | Muhammad Torequl Islam Marcello Iriti Hicham Harhar Youssef Elouafy Imane Chamkhi Eda Sönmez Gürer Javad Sharifi-Rad |
| author_facet | Muhammad Torequl Islam Marcello Iriti Hicham Harhar Youssef Elouafy Imane Chamkhi Eda Sönmez Gürer Javad Sharifi-Rad |
| author_sort | Muhammad Torequl Islam |
| collection | DOAJ |
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Background: Rabeprazole (RPZ), a widely used proton pump inhibitor, is known to have toxic effects on human beings.
Objective: To evaluate the current understanding of its toxicological effects on humans and animals, a literature and laboratory-based study was conducted.
Methods: A comprehensive search of published literature was conducted in various databases up until April 2020, using specific keywords. Additionally, toxic effects of RPZ-Na (0.025-0.4 mM) were evaluated on Allium cepa, Allium sativum and Cicer arietinum at different exposure times using CuSO4 as a reference standard.
Results: The literature review revealed that RPZ has a wide range of side effects including nausea, vomiting, diarrhea, headache, rhinitis, myalgia, pharyngitis, abdominal pain, dyspepsia, and eye disorders. Chronic exposure to RPZ has also been associated with significant biochemical and hematological alterations, as well as various toxicological effects such as hypergastrinemia, hyperplasia, atrophy of gastric glands, gastric anti-secretory effect, and hypochlorhydria. The laboratory analysis showed that RPZ-Na concentration-dependently inhibited root length of A. cepa and A. sativum, as well as shoot and root lengths of C. arietinum.
Conclusions: This study highlights the toxicological impacts of RPZ and its formulations on human and animals. Results suggest that RPZ-Na has a concentration-dependent toxic effect on A. cepa, A. sativum, and C. arietinum. Therefore, it is important to take adequate precautions during its long-term use.
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| format | Article |
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| institution | Kabale University |
| issn | 0121-4004 2145-2660 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Vitae |
| spelling | doaj-art-c6fbe0560d0f4b5abef5c4f6121d82ae2025-01-17T03:51:27ZengUniversidad de AntioquiaVitae0121-40042145-26602024-09-0131210.17533/udea.vitae.v31n2a352429Toxicological impact of rabeprazole and evaluation of toxic effects on the plant-based eukaryotic test modelsMuhammad Torequl Islam0Marcello Iriti1Hicham Harhar2Youssef Elouafy3Imane Chamkhi4Eda Sönmez Gürer5Javad Sharifi-Rad6Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityDepartment of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, Milan 20133, ItalyLaboratory of Materials, Nanotechnology and Environment, Faculty of Sciences, Mohammed V University in Rabat, Av. Ibn Battouta, B.P1014, Rabat, Morocco Laboratory of Materials, Nanotechnology and Environment, Faculty of Sciences, Mohammed V University in Rabat, Av. Ibn Battouta, B.P1014, Rabat, Morocco Laboratory of Materials, Nanotechnology and Environment, Faculty of Sciences, Mohammed V University in Rabat, Av. Ibn Battouta, B.P1014, Rabat, Morocco Sivas Cumhuriyet University, Faculty of Pharmacy, Department of Pharmacognosy, Sivas, TurkeyCentro de Estudios Tecnológicos y Universitarios del Golfo, Veracruz, Mexico Background: Rabeprazole (RPZ), a widely used proton pump inhibitor, is known to have toxic effects on human beings. Objective: To evaluate the current understanding of its toxicological effects on humans and animals, a literature and laboratory-based study was conducted. Methods: A comprehensive search of published literature was conducted in various databases up until April 2020, using specific keywords. Additionally, toxic effects of RPZ-Na (0.025-0.4 mM) were evaluated on Allium cepa, Allium sativum and Cicer arietinum at different exposure times using CuSO4 as a reference standard. Results: The literature review revealed that RPZ has a wide range of side effects including nausea, vomiting, diarrhea, headache, rhinitis, myalgia, pharyngitis, abdominal pain, dyspepsia, and eye disorders. Chronic exposure to RPZ has also been associated with significant biochemical and hematological alterations, as well as various toxicological effects such as hypergastrinemia, hyperplasia, atrophy of gastric glands, gastric anti-secretory effect, and hypochlorhydria. The laboratory analysis showed that RPZ-Na concentration-dependently inhibited root length of A. cepa and A. sativum, as well as shoot and root lengths of C. arietinum. Conclusions: This study highlights the toxicological impacts of RPZ and its formulations on human and animals. Results suggest that RPZ-Na has a concentration-dependent toxic effect on A. cepa, A. sativum, and C. arietinum. Therefore, it is important to take adequate precautions during its long-term use. https://revistas.udea.edu.co/index.php/vitae/article/view/352429RabeprazoleAllium cepaAllium sativumCicer arietinumToxicity monitoring tools |
| spellingShingle | Muhammad Torequl Islam Marcello Iriti Hicham Harhar Youssef Elouafy Imane Chamkhi Eda Sönmez Gürer Javad Sharifi-Rad Toxicological impact of rabeprazole and evaluation of toxic effects on the plant-based eukaryotic test models Vitae Rabeprazole Allium cepa Allium sativum Cicer arietinum Toxicity monitoring tools |
| title | Toxicological impact of rabeprazole and evaluation of toxic effects on the plant-based eukaryotic test models |
| title_full | Toxicological impact of rabeprazole and evaluation of toxic effects on the plant-based eukaryotic test models |
| title_fullStr | Toxicological impact of rabeprazole and evaluation of toxic effects on the plant-based eukaryotic test models |
| title_full_unstemmed | Toxicological impact of rabeprazole and evaluation of toxic effects on the plant-based eukaryotic test models |
| title_short | Toxicological impact of rabeprazole and evaluation of toxic effects on the plant-based eukaryotic test models |
| title_sort | toxicological impact of rabeprazole and evaluation of toxic effects on the plant based eukaryotic test models |
| topic | Rabeprazole Allium cepa Allium sativum Cicer arietinum Toxicity monitoring tools |
| url | https://revistas.udea.edu.co/index.php/vitae/article/view/352429 |
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