Small molecule protein assembly modulators with pan-cancer therapeutic efficacy

Small molecule protein assembly modulators with pan-cancer therapeutic efficacy

Two structurally unrelated small molecule chemotypes, represented by compounds PAV-617 and PAV-951, with antiviral activity in cell culture against Mpox virus (formerly known as monkeypox virus) and human immunodeficiency virus (HIV) respectively, were studied for anti-cancer efficacy. Each exhibite...

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Main Authors: Anuradha F. Lingappa, Olayemi Akintunde, Erin Samueli, Connie Ewald, Maya Michon, Niloufar Ziari, Ming Lu, Shao Feng Yu, Markus Froehlich, Phuong Uyen Le, Yuniel Fernandez, Suguna Mallesh, Jim Lin, Anatoliy Kitaygorodskyy, Dennis Solas, Jonathan C. Reed, Jaisri R. Lingappa, Andreas Müller-Schiffmann, Carsten Korth, Dharma Prasad, Aysegul Nalca, Emily Aston, Brad Fabbri, Sanjeev K. Anand, Thomas W. Campi, Emma Petrouski, Debendranath Dey, David W. Andrews, James L. Rubenstein, Vishwanath R. Lingappa
Format: Article
Language:English
Published: The Royal Society 2024-12-01
Series:Open Biology
Subjects:
drug discovery
pan-cancer therapeutics
allosteric modulator
restoration of homeostasis
multi-protein complex
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.240210
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https://royalsocietypublishing.org/doi/10.1098/rsob.240210

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