National and regional incidence patterns of venous thromboembolism in Finland during 1998–2021 with corresponding mortality trends in 1998–2019
Objectives: Previous research suggest that venous thromboembolism (VTE) -related mortality have been declining over the recent decades, despite the increasing trend of pulmonary embolism (PE) incidence. There is evidence of some regional differences in VTE incidence. We wanted to evaluate the nation...
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Elsevier
2025-09-01
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| Series: | Thrombosis Update |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666572725000100 |
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| author | Lasse Myllylahti Jari Haukka Eero Hirvensalo Riitta Lassila |
| author_facet | Lasse Myllylahti Jari Haukka Eero Hirvensalo Riitta Lassila |
| author_sort | Lasse Myllylahti |
| collection | DOAJ |
| description | Objectives: Previous research suggest that venous thromboembolism (VTE) -related mortality have been declining over the recent decades, despite the increasing trend of pulmonary embolism (PE) incidence. There is evidence of some regional differences in VTE incidence. We wanted to evaluate the national and regional 21st century VTE incidence in Finland, as well as respective national VTE mortality trends. Patients and methods: In this nationwide registry study, anonymous participants were patients with VTE diagnoses (I26 or I80) during hospital visits or VTE-related documentation of primary cause of death. To assess incidence, we recorded VTE-related hospital visits from the HILMO registry of the Finnish Institute for Health and Welfare. To assess mortality, we recorded deaths with a VTE diagnosis as a primary cause of death from the registries of Statistics Finland. Additionally, we acquired the data about pulmonary CT angiographies from STUK, which is the radiation and nuclear safety authority in Finland. Results: At the national level, the PE incidence doubled during the study period, while the incidence rates of deep vein thrombosis remained stable. Some regional variances in VTE incidence were encountered. The usage of radiological examinations to diagnose PE have become more frequent during the study period. The mortality for VTE peaked in 2004, following the clear declining trend during the follow-up period. Conclusion: Despite the remarkable increase in PE incidence, the mortality rates have been constantly declining from 2004. These results are valuable for the future epidemiological research of VTE. |
| format | Article |
| id | doaj-art-c6f359a23d704ee9b2e2e49c0a63fd4d |
| institution | Kabale University |
| issn | 2666-5727 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Thrombosis Update |
| spelling | doaj-art-c6f359a23d704ee9b2e2e49c0a63fd4d2025-08-20T03:50:22ZengElsevierThrombosis Update2666-57272025-09-012010020710.1016/j.tru.2025.100207National and regional incidence patterns of venous thromboembolism in Finland during 1998–2021 with corresponding mortality trends in 1998–2019Lasse Myllylahti0Jari Haukka1Eero Hirvensalo2Riitta Lassila3Helsinki University Hospital, Comprehensive Cancer Center, Department of Hematology, Helsinki, Finland; Corresponding author. Haartmaninkatu 4, 00290, Helsinki, Finland.University of Helsinki, Faculty of Medicine, Clinicum, Department of Public Health, FinlandHelsinki University Hospital, Corporation Administration Services, FinlandUniversity of Helsinki, Research Program Unit in Systems Oncology, Helsinki, Finland; Helsinki University Hospital, Comprehensive Cancer Center, Department of Hematology, Unit of Coagulation Disorders, Helsinki, FinlandObjectives: Previous research suggest that venous thromboembolism (VTE) -related mortality have been declining over the recent decades, despite the increasing trend of pulmonary embolism (PE) incidence. There is evidence of some regional differences in VTE incidence. We wanted to evaluate the national and regional 21st century VTE incidence in Finland, as well as respective national VTE mortality trends. Patients and methods: In this nationwide registry study, anonymous participants were patients with VTE diagnoses (I26 or I80) during hospital visits or VTE-related documentation of primary cause of death. To assess incidence, we recorded VTE-related hospital visits from the HILMO registry of the Finnish Institute for Health and Welfare. To assess mortality, we recorded deaths with a VTE diagnosis as a primary cause of death from the registries of Statistics Finland. Additionally, we acquired the data about pulmonary CT angiographies from STUK, which is the radiation and nuclear safety authority in Finland. Results: At the national level, the PE incidence doubled during the study period, while the incidence rates of deep vein thrombosis remained stable. Some regional variances in VTE incidence were encountered. The usage of radiological examinations to diagnose PE have become more frequent during the study period. The mortality for VTE peaked in 2004, following the clear declining trend during the follow-up period. Conclusion: Despite the remarkable increase in PE incidence, the mortality rates have been constantly declining from 2004. These results are valuable for the future epidemiological research of VTE.http://www.sciencedirect.com/science/article/pii/S2666572725000100Venous thromboembolismPulmonary embolismDeep vein thrombosisMortalityIncidenceEpidemiology |
| spellingShingle | Lasse Myllylahti Jari Haukka Eero Hirvensalo Riitta Lassila National and regional incidence patterns of venous thromboembolism in Finland during 1998–2021 with corresponding mortality trends in 1998–2019 Thrombosis Update Venous thromboembolism Pulmonary embolism Deep vein thrombosis Mortality Incidence Epidemiology |
| title | National and regional incidence patterns of venous thromboembolism in Finland during 1998–2021 with corresponding mortality trends in 1998–2019 |
| title_full | National and regional incidence patterns of venous thromboembolism in Finland during 1998–2021 with corresponding mortality trends in 1998–2019 |
| title_fullStr | National and regional incidence patterns of venous thromboembolism in Finland during 1998–2021 with corresponding mortality trends in 1998–2019 |
| title_full_unstemmed | National and regional incidence patterns of venous thromboembolism in Finland during 1998–2021 with corresponding mortality trends in 1998–2019 |
| title_short | National and regional incidence patterns of venous thromboembolism in Finland during 1998–2021 with corresponding mortality trends in 1998–2019 |
| title_sort | national and regional incidence patterns of venous thromboembolism in finland during 1998 2021 with corresponding mortality trends in 1998 2019 |
| topic | Venous thromboembolism Pulmonary embolism Deep vein thrombosis Mortality Incidence Epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S2666572725000100 |
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