Loss of cytoplasmic actin filaments raises nuclear actin levels to drive INO80C-dependent chromosome fragmentation

Loss of cytoplasmic actin filaments raises nuclear actin levels to drive INO80C-dependent chromosome fragmentation

Abstract Loss of cytosolic actin filaments upon TORC2 inhibition triggers chromosome fragmentation in yeast, which results from altered base excision repair of Zeocin-induced lesions. To find the link between TORC2 kinase and this yeast chromosome shattering (YCS) we performed phosphoproteomics. YCS...

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Main Authors: Verena Hurst, Christian B. Gerhold, Cleo V. D. Tarashev, Kiran Challa, Andrew Seeber, Shota Yamazaki, Britta Knapp, Stephen B. Helliwell, Bernd Bodenmiller, Masahiko Harata, Kenji Shimada, Susan M. Gasser
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54141-0
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