Inflammatory bowel disease in axial spondyloarthritis patients. Is there any specific clinical picture? Data from the RESPONDIA and REGISPONSER registries
Background: Inflammatory bowel disease (IBD) affects 5%–10% of ankylosing spondylitis (AS) patients. Prior data suggest AS patients with IBD may have more severe disease and lower HLA-B27 prevalence. Yet, little is known about potential distinctions in AS with IBD compared to those without IBD. Obje...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-11-01
|
| Series: | Therapeutic Advances in Musculoskeletal Disease |
| Online Access: | https://doi.org/10.1177/1759720X241303316 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846148769098235904 |
|---|---|
| author | Maria Llop Ignacio Gómez-García Jordi Gratacós Albert Villoria Joan Calvet Mireia Moreno Marta Arévalo Montserrat Cabanillas-Paredes Eduardo Collantes-Estévez Janitzia Vazquez-Mellado Clementina López-Medina |
| author_facet | Maria Llop Ignacio Gómez-García Jordi Gratacós Albert Villoria Joan Calvet Mireia Moreno Marta Arévalo Montserrat Cabanillas-Paredes Eduardo Collantes-Estévez Janitzia Vazquez-Mellado Clementina López-Medina |
| author_sort | Maria Llop |
| collection | DOAJ |
| description | Background: Inflammatory bowel disease (IBD) affects 5%–10% of ankylosing spondylitis (AS) patients. Prior data suggest AS patients with IBD may have more severe disease and lower HLA-B27 prevalence. Yet, little is known about potential distinctions in AS with IBD compared to those without IBD. Objective: To investigate the clinical characteristics and radiographic differences between patients with (AS) with and without concurrent IBD. Design: This multicenter, observational, cross-sectional study included patients meeting European Spondyloarthropathy Study Group criteria from the Registry of Spondyloarthritis of Spanish Rheumatology (REGISPONSER) and Ibero-American Registry of Spondyloarthropathies (RESPONDIA) registries. Methods: Characteristics and disease burden were compared between patients with and without IBD. Multivariate logistic regression identified factors independently associated with IBD presence in patients with AS. Results: We included a total of 2766 patients with AS (1254 from REGISPONSER and 1512 from RESPONDIA), among whom 142 patients (5.13%) presented with concomitant IBD. AS patients with concurrent IBD were less frequently male, had a lower prevalence of HLA-B27 positivity, experienced a lower prolonged diagnostic delay, had a lower frequency of enthesitis, and received more commonly intensified treatment compared to those without IBD. In terms of structural damage, the Bath Ankylosing Spondylitis Radiology Index (BASRI) score for the sacroiliac joints (SIJs), cervical spine, and lumbar spine was lower in patients with AS and IBD than in those without IBD. In the multivariable analysis, the presence of IBD was significantly associated with a lower prevalence of HLA-B27 and enthesitis, with odds ratios (OR) of 0.32 (95% confidence interval (CI): 0.20–0.52) and 0.58 (95% CI: 0.33–0.97), respectively. Furthermore, structural damage in SIJs (BASRI) was significantly decreased in patients with IBD, with an OR of 0.79 (95% CI: 0.64–0.99). Conclusion: The presence of IBD in AS is associated with lower HLA-B27 positivity, less enthesitis, and less radiographic damage in this large population study. |
| format | Article |
| id | doaj-art-c6e8ff13265344f49f0c13032db2eedb |
| institution | Kabale University |
| issn | 1759-7218 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Musculoskeletal Disease |
| spelling | doaj-art-c6e8ff13265344f49f0c13032db2eedb2024-11-30T10:03:40ZengSAGE PublishingTherapeutic Advances in Musculoskeletal Disease1759-72182024-11-011610.1177/1759720X241303316Inflammatory bowel disease in axial spondyloarthritis patients. Is there any specific clinical picture? Data from the RESPONDIA and REGISPONSER registriesMaria LlopIgnacio Gómez-GarcíaJordi GratacósAlbert VilloriaJoan CalvetMireia MorenoMarta ArévaloMontserrat Cabanillas-ParedesEduardo Collantes-EstévezJanitzia Vazquez-MelladoClementina López-MedinaBackground: Inflammatory bowel disease (IBD) affects 5%–10% of ankylosing spondylitis (AS) patients. Prior data suggest AS patients with IBD may have more severe disease and lower HLA-B27 prevalence. Yet, little is known about potential distinctions in AS with IBD compared to those without IBD. Objective: To investigate the clinical characteristics and radiographic differences between patients with (AS) with and without concurrent IBD. Design: This multicenter, observational, cross-sectional study included patients meeting European Spondyloarthropathy Study Group criteria from the Registry of Spondyloarthritis of Spanish Rheumatology (REGISPONSER) and Ibero-American Registry of Spondyloarthropathies (RESPONDIA) registries. Methods: Characteristics and disease burden were compared between patients with and without IBD. Multivariate logistic regression identified factors independently associated with IBD presence in patients with AS. Results: We included a total of 2766 patients with AS (1254 from REGISPONSER and 1512 from RESPONDIA), among whom 142 patients (5.13%) presented with concomitant IBD. AS patients with concurrent IBD were less frequently male, had a lower prevalence of HLA-B27 positivity, experienced a lower prolonged diagnostic delay, had a lower frequency of enthesitis, and received more commonly intensified treatment compared to those without IBD. In terms of structural damage, the Bath Ankylosing Spondylitis Radiology Index (BASRI) score for the sacroiliac joints (SIJs), cervical spine, and lumbar spine was lower in patients with AS and IBD than in those without IBD. In the multivariable analysis, the presence of IBD was significantly associated with a lower prevalence of HLA-B27 and enthesitis, with odds ratios (OR) of 0.32 (95% confidence interval (CI): 0.20–0.52) and 0.58 (95% CI: 0.33–0.97), respectively. Furthermore, structural damage in SIJs (BASRI) was significantly decreased in patients with IBD, with an OR of 0.79 (95% CI: 0.64–0.99). Conclusion: The presence of IBD in AS is associated with lower HLA-B27 positivity, less enthesitis, and less radiographic damage in this large population study.https://doi.org/10.1177/1759720X241303316 |
| spellingShingle | Maria Llop Ignacio Gómez-García Jordi Gratacós Albert Villoria Joan Calvet Mireia Moreno Marta Arévalo Montserrat Cabanillas-Paredes Eduardo Collantes-Estévez Janitzia Vazquez-Mellado Clementina López-Medina Inflammatory bowel disease in axial spondyloarthritis patients. Is there any specific clinical picture? Data from the RESPONDIA and REGISPONSER registries Therapeutic Advances in Musculoskeletal Disease |
| title | Inflammatory bowel disease in axial spondyloarthritis patients. Is there any specific clinical picture? Data from the RESPONDIA and REGISPONSER registries |
| title_full | Inflammatory bowel disease in axial spondyloarthritis patients. Is there any specific clinical picture? Data from the RESPONDIA and REGISPONSER registries |
| title_fullStr | Inflammatory bowel disease in axial spondyloarthritis patients. Is there any specific clinical picture? Data from the RESPONDIA and REGISPONSER registries |
| title_full_unstemmed | Inflammatory bowel disease in axial spondyloarthritis patients. Is there any specific clinical picture? Data from the RESPONDIA and REGISPONSER registries |
| title_short | Inflammatory bowel disease in axial spondyloarthritis patients. Is there any specific clinical picture? Data from the RESPONDIA and REGISPONSER registries |
| title_sort | inflammatory bowel disease in axial spondyloarthritis patients is there any specific clinical picture data from the respondia and regisponser registries |
| url | https://doi.org/10.1177/1759720X241303316 |
| work_keys_str_mv | AT mariallop inflammatoryboweldiseaseinaxialspondyloarthritispatientsisthereanyspecificclinicalpicturedatafromtherespondiaandregisponserregistries AT ignaciogomezgarcia inflammatoryboweldiseaseinaxialspondyloarthritispatientsisthereanyspecificclinicalpicturedatafromtherespondiaandregisponserregistries AT jordigratacos inflammatoryboweldiseaseinaxialspondyloarthritispatientsisthereanyspecificclinicalpicturedatafromtherespondiaandregisponserregistries AT albertvilloria inflammatoryboweldiseaseinaxialspondyloarthritispatientsisthereanyspecificclinicalpicturedatafromtherespondiaandregisponserregistries AT joancalvet inflammatoryboweldiseaseinaxialspondyloarthritispatientsisthereanyspecificclinicalpicturedatafromtherespondiaandregisponserregistries AT mireiamoreno inflammatoryboweldiseaseinaxialspondyloarthritispatientsisthereanyspecificclinicalpicturedatafromtherespondiaandregisponserregistries AT martaarevalo inflammatoryboweldiseaseinaxialspondyloarthritispatientsisthereanyspecificclinicalpicturedatafromtherespondiaandregisponserregistries AT montserratcabanillasparedes inflammatoryboweldiseaseinaxialspondyloarthritispatientsisthereanyspecificclinicalpicturedatafromtherespondiaandregisponserregistries AT eduardocollantesestevez inflammatoryboweldiseaseinaxialspondyloarthritispatientsisthereanyspecificclinicalpicturedatafromtherespondiaandregisponserregistries AT janitziavazquezmellado inflammatoryboweldiseaseinaxialspondyloarthritispatientsisthereanyspecificclinicalpicturedatafromtherespondiaandregisponserregistries AT clementinalopezmedina inflammatoryboweldiseaseinaxialspondyloarthritispatientsisthereanyspecificclinicalpicturedatafromtherespondiaandregisponserregistries |