A tandem approach for the synthesis of 1-phenyl-pyrazolo-quinolinones by Fe3O4@MWCNT nanocomposite as heterogeneous catalyst
A simple, facile, efficient and highly promising protocol for the synthesis of 1-phenyl-pyrazolo-quinolinone analogs using Fe3O4@MWCNT nano-composite as a catalyst via Knoevenagel–Michael reaction has been developed. The use of Fe3O4@MWCNT nano-composite as a catalyst has several advantages, like si...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Green Chemistry Letters and Reviews |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/17518253.2024.2449137 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841546536117338112 |
|---|---|
| author | Adapaka Venkateswara Rao Suresh Maddila Nagaraju Kerru Sreekantha B. Jonnalagadda |
| author_facet | Adapaka Venkateswara Rao Suresh Maddila Nagaraju Kerru Sreekantha B. Jonnalagadda |
| author_sort | Adapaka Venkateswara Rao |
| collection | DOAJ |
| description | A simple, facile, efficient and highly promising protocol for the synthesis of 1-phenyl-pyrazolo-quinolinone analogs using Fe3O4@MWCNT nano-composite as a catalyst via Knoevenagel–Michael reaction has been developed. The use of Fe3O4@MWCNT nano-composite as a catalyst has several advantages, like simple preparation, inexpensive, simple handling, and high stability. It was synthesized from MWCNT and iron oxide and was thoroughly characterized using BET, PXRD, SEM, TEM, and TGA analysis. All the synthesized target molecules were characterized and confirmed by various spectroscopic techniques such as 1H-NMR, 15N-NMR, 13C-NMR, and HRMS. The present work unveils a promising and environmentally friendly approach for synthesizing phenyl-pyrazolo-quinolinone scaffolds with higher yields (93–97%), selectivity, efficiency, using mild reaction conditions, no need for chromatographic separation, short reaction times, catalyst recovery and reuse for a minimum of seven cycles is possible without causing a notable reduction in product yields. The method complies with green chemistry principles and presents a feasible alternative to previously documented techniques. |
| format | Article |
| id | doaj-art-c6e564d2130945299305934378db7ff6 |
| institution | Kabale University |
| issn | 1751-8253 1751-7192 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Green Chemistry Letters and Reviews |
| spelling | doaj-art-c6e564d2130945299305934378db7ff62025-01-10T16:51:53ZengTaylor & Francis GroupGreen Chemistry Letters and Reviews1751-82531751-71922025-12-0118110.1080/17518253.2024.2449137A tandem approach for the synthesis of 1-phenyl-pyrazolo-quinolinones by Fe3O4@MWCNT nanocomposite as heterogeneous catalystAdapaka Venkateswara Rao0Suresh Maddila1Nagaraju Kerru2Sreekantha B. Jonnalagadda3Department of Chemistry, GITAM School of Science, GITAM University, Visakhapatnam, IndiaDepartment of Chemistry, GITAM School of Science, GITAM University, Visakhapatnam, IndiaSchool of Chemistry & Physics, University of KwaZulu-Natal, Durban, South AfricaSchool of Chemistry & Physics, University of KwaZulu-Natal, Durban, South AfricaA simple, facile, efficient and highly promising protocol for the synthesis of 1-phenyl-pyrazolo-quinolinone analogs using Fe3O4@MWCNT nano-composite as a catalyst via Knoevenagel–Michael reaction has been developed. The use of Fe3O4@MWCNT nano-composite as a catalyst has several advantages, like simple preparation, inexpensive, simple handling, and high stability. It was synthesized from MWCNT and iron oxide and was thoroughly characterized using BET, PXRD, SEM, TEM, and TGA analysis. All the synthesized target molecules were characterized and confirmed by various spectroscopic techniques such as 1H-NMR, 15N-NMR, 13C-NMR, and HRMS. The present work unveils a promising and environmentally friendly approach for synthesizing phenyl-pyrazolo-quinolinone scaffolds with higher yields (93–97%), selectivity, efficiency, using mild reaction conditions, no need for chromatographic separation, short reaction times, catalyst recovery and reuse for a minimum of seven cycles is possible without causing a notable reduction in product yields. The method complies with green chemistry principles and presents a feasible alternative to previously documented techniques.https://www.tandfonline.com/doi/10.1080/17518253.2024.2449137Green synthesisMWCNTone-pot reactionrecyclabiltyenvironmental-benign |
| spellingShingle | Adapaka Venkateswara Rao Suresh Maddila Nagaraju Kerru Sreekantha B. Jonnalagadda A tandem approach for the synthesis of 1-phenyl-pyrazolo-quinolinones by Fe3O4@MWCNT nanocomposite as heterogeneous catalyst Green Chemistry Letters and Reviews Green synthesis MWCNT one-pot reaction recyclabilty environmental-benign |
| title | A tandem approach for the synthesis of 1-phenyl-pyrazolo-quinolinones by Fe3O4@MWCNT nanocomposite as heterogeneous catalyst |
| title_full | A tandem approach for the synthesis of 1-phenyl-pyrazolo-quinolinones by Fe3O4@MWCNT nanocomposite as heterogeneous catalyst |
| title_fullStr | A tandem approach for the synthesis of 1-phenyl-pyrazolo-quinolinones by Fe3O4@MWCNT nanocomposite as heterogeneous catalyst |
| title_full_unstemmed | A tandem approach for the synthesis of 1-phenyl-pyrazolo-quinolinones by Fe3O4@MWCNT nanocomposite as heterogeneous catalyst |
| title_short | A tandem approach for the synthesis of 1-phenyl-pyrazolo-quinolinones by Fe3O4@MWCNT nanocomposite as heterogeneous catalyst |
| title_sort | tandem approach for the synthesis of 1 phenyl pyrazolo quinolinones by fe3o4 mwcnt nanocomposite as heterogeneous catalyst |
| topic | Green synthesis MWCNT one-pot reaction recyclabilty environmental-benign |
| url | https://www.tandfonline.com/doi/10.1080/17518253.2024.2449137 |
| work_keys_str_mv | AT adapakavenkateswararao atandemapproachforthesynthesisof1phenylpyrazoloquinolinonesbyfe3o4mwcntnanocompositeasheterogeneouscatalyst AT sureshmaddila atandemapproachforthesynthesisof1phenylpyrazoloquinolinonesbyfe3o4mwcntnanocompositeasheterogeneouscatalyst AT nagarajukerru atandemapproachforthesynthesisof1phenylpyrazoloquinolinonesbyfe3o4mwcntnanocompositeasheterogeneouscatalyst AT sreekanthabjonnalagadda atandemapproachforthesynthesisof1phenylpyrazoloquinolinonesbyfe3o4mwcntnanocompositeasheterogeneouscatalyst AT adapakavenkateswararao tandemapproachforthesynthesisof1phenylpyrazoloquinolinonesbyfe3o4mwcntnanocompositeasheterogeneouscatalyst AT sureshmaddila tandemapproachforthesynthesisof1phenylpyrazoloquinolinonesbyfe3o4mwcntnanocompositeasheterogeneouscatalyst AT nagarajukerru tandemapproachforthesynthesisof1phenylpyrazoloquinolinonesbyfe3o4mwcntnanocompositeasheterogeneouscatalyst AT sreekanthabjonnalagadda tandemapproachforthesynthesisof1phenylpyrazoloquinolinonesbyfe3o4mwcntnanocompositeasheterogeneouscatalyst |