Stromal modifying CHST15 siRNA enhances antitumor effect synergistically with anti-PD-1 immune checkpoint antibody in murine pancreatic cancer

Stromal modifying CHST15 siRNA enhances antitumor effect synergistically with anti-PD-1 immune checkpoint antibody in murine pancreatic cancer

Abstract Tumor stromal remodeling is an obstacle for immune checkpoint inhibitors (ICI). A stroma modifying small interfering RNA (siRNA) to carbohydrate sulfotransferase 15 (CHST15) was recently shown to enhance tumor-infiltrating T cells, yet its impact on antitumor response of ICI remains unexplo...

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Bibliographic Details
Main Authors: Juanjuan Ye, Futoshi Suizu, Keiko Yamakawa, Hiroyuki Yoneyama, Jiro Kondo, Motohiko Kato, Akira Nishiyama, Naohisa Yahagi, Kyuichi Kadota
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Pancreatic ductal adenocarcinoma (PDAC)
Myeloid-derived suppressor cells (MDSCs)
Immune checkpoint inhibitors (ICI)
Carbohydrate sulfotransferase 15 (CHST15)
Chondroitin sulfate E (CS-E)
T cell
Online Access:https://doi.org/10.1038/s41598-025-09445-6
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