Analysis of Circulating Catestatin in Early Pregnancy: A Preliminary Investigation
<b>Background:</b> During pregnancy, significant cardiovascular changes occur to accommodate fetal growth, and catestatin may play a role in these changes. Evidence suggests that catestatin, a pleiotropic sympathoinhibitory peptide, is involved in multiple cardiovascular pathologies, inc...
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2024-11-01
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| author | Zdenka Sunjic Lovric Jasminka Resic Karara Bianka Mimica Marko Kumric Daniela Supe-Domic Roko Santic Josko Bozic |
| author_facet | Zdenka Sunjic Lovric Jasminka Resic Karara Bianka Mimica Marko Kumric Daniela Supe-Domic Roko Santic Josko Bozic |
| author_sort | Zdenka Sunjic Lovric |
| collection | DOAJ |
| description | <b>Background:</b> During pregnancy, significant cardiovascular changes occur to accommodate fetal growth, and catestatin may play a role in these changes. Evidence suggests that catestatin, a pleiotropic sympathoinhibitory peptide, is involved in multiple cardiovascular pathologies, including hypertensive disorders. The objective of this study was to compare serum catestatin levels between first-trimester pregnant women and non-pregnant women, aiming to investigate catestatin’s role in blood pressure regulation during early pregnancy. <b>Methods:</b> This cross-sectional study included 72 first-trimester pregnant women and 57 age-matched non-pregnant controls, all without known cardiovascular or metabolic disorders. <b>Results:</b> Serum catestatin concentrations were significantly higher in pregnant women compared to controls (12.4 (9.9–21.2) ng/mL vs. 7.1 (4.5–10.9) ng/mL, <i>p</i> < 0.001). However, there was no significant difference in serum catestatin levels between those with a normal and abnormal uterine artery pulsatility index (17.8 (8.3-22.3) ng/mL vs. 12.5 (9.9–22.4) ng/mL, <i>p</i> = 0.962). Similarly, catestatin concentrations did not significantly differ between primiparous and multiparous women (14.0 (11.5–22.4) ng/mL vs. 10.7 (8.8–19.0) ng/mL). A positive correlation was observed between systolic blood pressure and serum catestatin levels in the control group (r = 0.335, <i>p</i> = 0.011) but not in pregnant women. <b>Conclusions:</b> Research on catestatin in pregnancy is still in its early stages, necessitating further studies to fully elucidate its roles and potential therapeutic applications. |
| format | Article |
| id | doaj-art-c6ce231ca8ee4bacbd3dc71815826fb3 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-c6ce231ca8ee4bacbd3dc71815826fb32024-11-26T17:53:28ZengMDPI AGBiomedicines2227-90592024-11-011211262610.3390/biomedicines12112626Analysis of Circulating Catestatin in Early Pregnancy: A Preliminary InvestigationZdenka Sunjic Lovric0Jasminka Resic Karara1Bianka Mimica2Marko Kumric3Daniela Supe-Domic4Roko Santic5Josko Bozic6Department of Gynecology and Obstetrics, University Hospital of Split, Spinciceva 1, 21000 Split, CroatiaDepartment of Gynecology and Obstetrics, University Hospital of Split, Spinciceva 1, 21000 Split, CroatiaDepartment of Gynecology and Obstetrics, University Hospital of Split, Spinciceva 1, 21000 Split, CroatiaDepartment of Pathophysiology, University of Split School of Medicine, Soltanska 2A, 21000 Split, CroatiaDepartment of Health Studies, University of Split, Rudera Boskovica 35, 21000 Split, CroatiaDepartment of Pathophysiology, University of Split School of Medicine, Soltanska 2A, 21000 Split, CroatiaDepartment of Pathophysiology, University of Split School of Medicine, Soltanska 2A, 21000 Split, Croatia<b>Background:</b> During pregnancy, significant cardiovascular changes occur to accommodate fetal growth, and catestatin may play a role in these changes. Evidence suggests that catestatin, a pleiotropic sympathoinhibitory peptide, is involved in multiple cardiovascular pathologies, including hypertensive disorders. The objective of this study was to compare serum catestatin levels between first-trimester pregnant women and non-pregnant women, aiming to investigate catestatin’s role in blood pressure regulation during early pregnancy. <b>Methods:</b> This cross-sectional study included 72 first-trimester pregnant women and 57 age-matched non-pregnant controls, all without known cardiovascular or metabolic disorders. <b>Results:</b> Serum catestatin concentrations were significantly higher in pregnant women compared to controls (12.4 (9.9–21.2) ng/mL vs. 7.1 (4.5–10.9) ng/mL, <i>p</i> < 0.001). However, there was no significant difference in serum catestatin levels between those with a normal and abnormal uterine artery pulsatility index (17.8 (8.3-22.3) ng/mL vs. 12.5 (9.9–22.4) ng/mL, <i>p</i> = 0.962). Similarly, catestatin concentrations did not significantly differ between primiparous and multiparous women (14.0 (11.5–22.4) ng/mL vs. 10.7 (8.8–19.0) ng/mL). A positive correlation was observed between systolic blood pressure and serum catestatin levels in the control group (r = 0.335, <i>p</i> = 0.011) but not in pregnant women. <b>Conclusions:</b> Research on catestatin in pregnancy is still in its early stages, necessitating further studies to fully elucidate its roles and potential therapeutic applications.https://www.mdpi.com/2227-9059/12/11/2626pregnancycardiovascular systemcatestatinpreeclampsia |
| spellingShingle | Zdenka Sunjic Lovric Jasminka Resic Karara Bianka Mimica Marko Kumric Daniela Supe-Domic Roko Santic Josko Bozic Analysis of Circulating Catestatin in Early Pregnancy: A Preliminary Investigation Biomedicines pregnancy cardiovascular system catestatin preeclampsia |
| title | Analysis of Circulating Catestatin in Early Pregnancy: A Preliminary Investigation |
| title_full | Analysis of Circulating Catestatin in Early Pregnancy: A Preliminary Investigation |
| title_fullStr | Analysis of Circulating Catestatin in Early Pregnancy: A Preliminary Investigation |
| title_full_unstemmed | Analysis of Circulating Catestatin in Early Pregnancy: A Preliminary Investigation |
| title_short | Analysis of Circulating Catestatin in Early Pregnancy: A Preliminary Investigation |
| title_sort | analysis of circulating catestatin in early pregnancy a preliminary investigation |
| topic | pregnancy cardiovascular system catestatin preeclampsia |
| url | https://www.mdpi.com/2227-9059/12/11/2626 |
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