Exploration of JAK/STAT pathway activation in ulcerative colitis reveals sex-dependent activation of JAK2/STAT3 in the inflammatory response

Exploration of JAK/STAT pathway activation in ulcerative colitis reveals sex-dependent activation of JAK2/STAT3 in the inflammatory response

IntroductionUlcerative colitis (UC) is characterized by aberrant immune responses involving multiple inflammatory pathways, including JAK/STAT signaling. However, the specific roles and interactions of individual components within this pathway remain unclear.MethodsWe conducted a prospective, observ...

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Main Authors: Cristina Calviño-Suárez, Mariña Durán-Rubí, José Brea, David Moreira, Inés Ardao, Iria Brocos-Mosquera, Rocío Ferreiro-Iglesias, Sol Porto-Silva, Laura Nieto-Garcia, María José Varela, María Isabel Loza, Antón L. Martínez, Manuel Barreiro-de Acosta
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
ulcerative colitis
JAK/STAT pathway
phosphorylation
sex-specific differences
inflammatory signaling
personalized therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609740/full
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