An auxiliary diagnostic approach based on traditional Chinese medicine constitutions for older patients with frailty
Abstract Introduction As global population ages, frailty has surfaced as a major public health challenge. Given the heterogeneity of frailty in the clinical presentation, it is imperative to develop personalised diagnostic and treatment strategies. The traditional Chinese medicine (TCM) constitution...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-12-01
|
| Series: | Clinical and Translational Discovery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctd2.70019 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846108097832026112 |
|---|---|
| author | Xuchao Gu Xiaojun Wang Yijing Yang Kangwei Guan Hung‐Chen Chang Dehua Liu Wenhao Wang Tao Wu Peiqing He Jiaofeng Wang Jie Chen Zhijun Bao |
| author_facet | Xuchao Gu Xiaojun Wang Yijing Yang Kangwei Guan Hung‐Chen Chang Dehua Liu Wenhao Wang Tao Wu Peiqing He Jiaofeng Wang Jie Chen Zhijun Bao |
| author_sort | Xuchao Gu |
| collection | DOAJ |
| description | Abstract Introduction As global population ages, frailty has surfaced as a major public health challenge. Given the heterogeneity of frailty in the clinical presentation, it is imperative to develop personalised diagnostic and treatment strategies. The traditional Chinese medicine (TCM) constitution offers notable advantages in discerning individual differences. This study aims to elucidate the association between TCM constitutions and frailty, providing insights into the application of TCM for the frailty management. Methods An observational study was conducted at Huadong hospital from July 2022 to November 2023. A total of 241 older patients were recruited. Each patient underwent assessments for the TCM constitution and frailty status. Comprehensive data collection encompassed medical history, biochemical indicators, bone mineral density (BMD), body composition and physical performance metrics. Plasma samples were also collected to detect levels of inflammatory factors and lymphogenesis‐related factors, including IL‐1β, TNF‐α, VEGF‐C, ANGPTL4 and ACV‐A. Multi‐level statistical analysis was used to establish the relationship of TCM constitutions with frailty. Results Amongst all participants, 54 individuals were classified as non‐frail, 90 individuals as pre‐frail and 97 individuals as frail. Regression analysis indicated that frailty was closely associated with four imbalanced TCM constitutions: Qi deficiency, phlegm dampness, blood stasis and Qi depression. Subsequent analysis demonstrated that Qi deficiency was associated with decreased BMD, phlegm dampness with elevated high‐density lipoprotein levels, Blood stasis with elevated blood glucose levels, and Qi depression with both decreased BMD and elevated low‐density lipoprotein levels. Furthermore, individuals characterised by imbalanced TCM constitutions exhibited inferior handgrip strength, walking pace, lower limb strength and higher levels of inflammatory factors and lymphogenesis‐related factors compared to those with balanced TCM constitution. Conclusion Frailty is independently associated with Qi deficiency, phlegm dampness, blood stasis and Qi depression. Personalised diagnostic approaches based on the TCM constitution may offer valuable insights for directing treatment for older patients with frailty. |
| format | Article |
| id | doaj-art-c699ba1ee6d44f348193f620da87c982 |
| institution | Kabale University |
| issn | 2768-0622 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Discovery |
| spelling | doaj-art-c699ba1ee6d44f348193f620da87c9822024-12-26T04:02:32ZengWileyClinical and Translational Discovery2768-06222024-12-0146n/an/a10.1002/ctd2.70019An auxiliary diagnostic approach based on traditional Chinese medicine constitutions for older patients with frailtyXuchao Gu0Xiaojun Wang1Yijing Yang2Kangwei Guan3Hung‐Chen Chang4Dehua Liu5Wenhao Wang6Tao Wu7Peiqing He8Jiaofeng Wang9Jie Chen10Zhijun Bao11Department of Traditional Chinese Medicine Huadong Hospital Affiliated to Fudan University Shanghai ChinaShanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan University Shanghai ChinaDepartment of Traditional Chinese Medicine Huadong Hospital Affiliated to Fudan University Shanghai ChinaDepartment of Traditional Chinese Medicine Huadong Hospital Affiliated to Fudan University Shanghai ChinaShanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan University Shanghai ChinaDepartment of Traditional Chinese Medicine Huadong Hospital Affiliated to Fudan University Shanghai ChinaDepartment of Traditional Chinese Medicine Huadong Hospital Affiliated to Fudan University Shanghai ChinaDepartment of Traditional Chinese Medicine Huadong Hospital Affiliated to Fudan University Shanghai ChinaDepartment of Traditional Chinese Medicine Huadong Hospital Affiliated to Fudan University Shanghai ChinaDepartment of Gerontology Huadong Hospital Affiliated to Fudan University Shanghai ChinaDepartment of Gerontology Huadong Hospital Affiliated to Fudan University Shanghai ChinaShanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan University Shanghai ChinaAbstract Introduction As global population ages, frailty has surfaced as a major public health challenge. Given the heterogeneity of frailty in the clinical presentation, it is imperative to develop personalised diagnostic and treatment strategies. The traditional Chinese medicine (TCM) constitution offers notable advantages in discerning individual differences. This study aims to elucidate the association between TCM constitutions and frailty, providing insights into the application of TCM for the frailty management. Methods An observational study was conducted at Huadong hospital from July 2022 to November 2023. A total of 241 older patients were recruited. Each patient underwent assessments for the TCM constitution and frailty status. Comprehensive data collection encompassed medical history, biochemical indicators, bone mineral density (BMD), body composition and physical performance metrics. Plasma samples were also collected to detect levels of inflammatory factors and lymphogenesis‐related factors, including IL‐1β, TNF‐α, VEGF‐C, ANGPTL4 and ACV‐A. Multi‐level statistical analysis was used to establish the relationship of TCM constitutions with frailty. Results Amongst all participants, 54 individuals were classified as non‐frail, 90 individuals as pre‐frail and 97 individuals as frail. Regression analysis indicated that frailty was closely associated with four imbalanced TCM constitutions: Qi deficiency, phlegm dampness, blood stasis and Qi depression. Subsequent analysis demonstrated that Qi deficiency was associated with decreased BMD, phlegm dampness with elevated high‐density lipoprotein levels, Blood stasis with elevated blood glucose levels, and Qi depression with both decreased BMD and elevated low‐density lipoprotein levels. Furthermore, individuals characterised by imbalanced TCM constitutions exhibited inferior handgrip strength, walking pace, lower limb strength and higher levels of inflammatory factors and lymphogenesis‐related factors compared to those with balanced TCM constitution. Conclusion Frailty is independently associated with Qi deficiency, phlegm dampness, blood stasis and Qi depression. Personalised diagnostic approaches based on the TCM constitution may offer valuable insights for directing treatment for older patients with frailty.https://doi.org/10.1002/ctd2.70019frailtyinflammationlymphogenesistraditional Chinese medicine constitution |
| spellingShingle | Xuchao Gu Xiaojun Wang Yijing Yang Kangwei Guan Hung‐Chen Chang Dehua Liu Wenhao Wang Tao Wu Peiqing He Jiaofeng Wang Jie Chen Zhijun Bao An auxiliary diagnostic approach based on traditional Chinese medicine constitutions for older patients with frailty Clinical and Translational Discovery frailty inflammation lymphogenesis traditional Chinese medicine constitution |
| title | An auxiliary diagnostic approach based on traditional Chinese medicine constitutions for older patients with frailty |
| title_full | An auxiliary diagnostic approach based on traditional Chinese medicine constitutions for older patients with frailty |
| title_fullStr | An auxiliary diagnostic approach based on traditional Chinese medicine constitutions for older patients with frailty |
| title_full_unstemmed | An auxiliary diagnostic approach based on traditional Chinese medicine constitutions for older patients with frailty |
| title_short | An auxiliary diagnostic approach based on traditional Chinese medicine constitutions for older patients with frailty |
| title_sort | auxiliary diagnostic approach based on traditional chinese medicine constitutions for older patients with frailty |
| topic | frailty inflammation lymphogenesis traditional Chinese medicine constitution |
| url | https://doi.org/10.1002/ctd2.70019 |
| work_keys_str_mv | AT xuchaogu anauxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT xiaojunwang anauxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT yijingyang anauxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT kangweiguan anauxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT hungchenchang anauxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT dehualiu anauxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT wenhaowang anauxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT taowu anauxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT peiqinghe anauxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT jiaofengwang anauxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT jiechen anauxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT zhijunbao anauxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT xuchaogu auxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT xiaojunwang auxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT yijingyang auxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT kangweiguan auxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT hungchenchang auxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT dehualiu auxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT wenhaowang auxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT taowu auxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT peiqinghe auxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT jiaofengwang auxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT jiechen auxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty AT zhijunbao auxiliarydiagnosticapproachbasedontraditionalchinesemedicineconstitutionsforolderpatientswithfrailty |