IRE1β evolves to be a guardian of respiratory and gastrointestinal mucosa
Inositol-requiring enzyme 1 (IRE1), a mediator of the unfolded protein response, shows the highest degree of evolutionary conservation. Vertebrates express two IRE1 paralogs: IRE1α, which is universally expressed and IRE1β, which shows specific expression within mucus secreted cells in respiratory a...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024150426 |
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| author | Hui Luo Wen-Yan Gong Yuan-Yuan Zhang Ying-Ying Liu Zhen Chen Xing-Lin Feng Qi-Bin Jiao Xing-Wei Zhang |
| author_facet | Hui Luo Wen-Yan Gong Yuan-Yuan Zhang Ying-Ying Liu Zhen Chen Xing-Lin Feng Qi-Bin Jiao Xing-Wei Zhang |
| author_sort | Hui Luo |
| collection | DOAJ |
| description | Inositol-requiring enzyme 1 (IRE1), a mediator of the unfolded protein response, shows the highest degree of evolutionary conservation. Vertebrates express two IRE1 paralogs: IRE1α, which is universally expressed and IRE1β, which shows specific expression within mucus secreted cells in respiratory and gastrointestinal tracts. The biological properties and regulation of the two IRE1 duplicates show evolutionary differences. As recently suggested, IRE1β-deficient mice display impairment in secreted protein expression and mucosal homeostasis. Abnormal changes in IRE1β caused by external and internal factors can disrupt mucosal homeostasis and further lead to respiratory and gastrointestinal diseases. Here, we highlight the physiological functions of IRE1β in the respiratory and gastrointestinal tracts in response to environmental microbes, viruses, toxins, and food components. |
| format | Article |
| id | doaj-art-c68c0fbc8ae641648ebcd63843143366 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-c68c0fbc8ae641648ebcd638431433662024-11-15T06:12:32ZengElsevierHeliyon2405-84402024-11-011021e39011IRE1β evolves to be a guardian of respiratory and gastrointestinal mucosaHui Luo0Wen-Yan Gong1Yuan-Yuan Zhang2Ying-Ying Liu3Zhen Chen4Xing-Lin Feng5Qi-Bin Jiao6Xing-Wei Zhang7School of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China; Corresponding author.School of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, ChinaDepartment of Cardiovascular Ultrasonic Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaSchool of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, ChinaSchool of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, ChinaSchool of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, ChinaSchool of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China; Corresponding author.School of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China; Corresponding author.Inositol-requiring enzyme 1 (IRE1), a mediator of the unfolded protein response, shows the highest degree of evolutionary conservation. Vertebrates express two IRE1 paralogs: IRE1α, which is universally expressed and IRE1β, which shows specific expression within mucus secreted cells in respiratory and gastrointestinal tracts. The biological properties and regulation of the two IRE1 duplicates show evolutionary differences. As recently suggested, IRE1β-deficient mice display impairment in secreted protein expression and mucosal homeostasis. Abnormal changes in IRE1β caused by external and internal factors can disrupt mucosal homeostasis and further lead to respiratory and gastrointestinal diseases. Here, we highlight the physiological functions of IRE1β in the respiratory and gastrointestinal tracts in response to environmental microbes, viruses, toxins, and food components.http://www.sciencedirect.com/science/article/pii/S2405844024150426Unfolded protein responseEvolutionary conservationIRE1αIRE1βMucosal homeostasis |
| spellingShingle | Hui Luo Wen-Yan Gong Yuan-Yuan Zhang Ying-Ying Liu Zhen Chen Xing-Lin Feng Qi-Bin Jiao Xing-Wei Zhang IRE1β evolves to be a guardian of respiratory and gastrointestinal mucosa Heliyon Unfolded protein response Evolutionary conservation IRE1α IRE1β Mucosal homeostasis |
| title | IRE1β evolves to be a guardian of respiratory and gastrointestinal mucosa |
| title_full | IRE1β evolves to be a guardian of respiratory and gastrointestinal mucosa |
| title_fullStr | IRE1β evolves to be a guardian of respiratory and gastrointestinal mucosa |
| title_full_unstemmed | IRE1β evolves to be a guardian of respiratory and gastrointestinal mucosa |
| title_short | IRE1β evolves to be a guardian of respiratory and gastrointestinal mucosa |
| title_sort | ire1β evolves to be a guardian of respiratory and gastrointestinal mucosa |
| topic | Unfolded protein response Evolutionary conservation IRE1α IRE1β Mucosal homeostasis |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024150426 |
| work_keys_str_mv | AT huiluo ire1bevolvestobeaguardianofrespiratoryandgastrointestinalmucosa AT wenyangong ire1bevolvestobeaguardianofrespiratoryandgastrointestinalmucosa AT yuanyuanzhang ire1bevolvestobeaguardianofrespiratoryandgastrointestinalmucosa AT yingyingliu ire1bevolvestobeaguardianofrespiratoryandgastrointestinalmucosa AT zhenchen ire1bevolvestobeaguardianofrespiratoryandgastrointestinalmucosa AT xinglinfeng ire1bevolvestobeaguardianofrespiratoryandgastrointestinalmucosa AT qibinjiao ire1bevolvestobeaguardianofrespiratoryandgastrointestinalmucosa AT xingweizhang ire1bevolvestobeaguardianofrespiratoryandgastrointestinalmucosa |