Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age.
Of all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity have been identified, the effects of these longevity-promoting factors on learning and memory are unknown. Here we show that the C. elegans Insulin/IGF-1 receptor mutant daf-2 improv...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-05-01
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| Series: | PLoS Biology |
| Online Access: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000372&type=printable |
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| author | Amanda L Kauffman Jasmine M Ashraf M Ryan Corces-Zimmerman Jessica N Landis Coleen T Murphy |
| author_facet | Amanda L Kauffman Jasmine M Ashraf M Ryan Corces-Zimmerman Jessica N Landis Coleen T Murphy |
| author_sort | Amanda L Kauffman |
| collection | DOAJ |
| description | Of all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity have been identified, the effects of these longevity-promoting factors on learning and memory are unknown. Here we show that the C. elegans Insulin/IGF-1 receptor mutant daf-2 improves memory performance early in adulthood and maintains learning ability better with age but, surprisingly, demonstrates no extension in long-term memory with age. By contrast, eat-2 mutants, a model of Dietary Restriction (DR), exhibit impaired long-term memory in young adulthood but maintain this level of memory longer with age. We find that crh-1, the C. elegans homolog of the CREB transcription factor, is required for long-term associative memory, but not for learning or short-term memory. The expression of crh-1 declines with age and differs in the longevity mutants, and CREB expression and activity correlate with memory performance. Our results suggest that specific longevity treatments have acute and long-term effects on cognitive functions that decline with age through their regulation of rate-limiting genes required for learning and memory. |
| format | Article |
| id | doaj-art-c677c21359b6446cad513df00da03554 |
| institution | Kabale University |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2010-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-c677c21359b6446cad513df00da035542025-01-17T05:30:44ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852010-05-0185e100037210.1371/journal.pbio.1000372Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age.Amanda L KauffmanJasmine M AshrafM Ryan Corces-ZimmermanJessica N LandisColeen T MurphyOf all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity have been identified, the effects of these longevity-promoting factors on learning and memory are unknown. Here we show that the C. elegans Insulin/IGF-1 receptor mutant daf-2 improves memory performance early in adulthood and maintains learning ability better with age but, surprisingly, demonstrates no extension in long-term memory with age. By contrast, eat-2 mutants, a model of Dietary Restriction (DR), exhibit impaired long-term memory in young adulthood but maintain this level of memory longer with age. We find that crh-1, the C. elegans homolog of the CREB transcription factor, is required for long-term associative memory, but not for learning or short-term memory. The expression of crh-1 declines with age and differs in the longevity mutants, and CREB expression and activity correlate with memory performance. Our results suggest that specific longevity treatments have acute and long-term effects on cognitive functions that decline with age through their regulation of rate-limiting genes required for learning and memory.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000372&type=printable |
| spellingShingle | Amanda L Kauffman Jasmine M Ashraf M Ryan Corces-Zimmerman Jessica N Landis Coleen T Murphy Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. PLoS Biology |
| title | Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. |
| title_full | Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. |
| title_fullStr | Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. |
| title_full_unstemmed | Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. |
| title_short | Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. |
| title_sort | insulin signaling and dietary restriction differentially influence the decline of learning and memory with age |
| url | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000372&type=printable |
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