Efficacy of Bacillus clausii UBBC-07 in the prevention of antibiotic-associated diarrhea in children
The effectiveness of the probiotic strain Bacillus clausii UBBC-07, was evaluated in the prevention of antibiotic-associated diarrhea. The study analyzed the treatment outcomes of 939 patients aged 28 days to 18 years with bacterial infections of various localizations, receiving systemic antibacteri...
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Zaslavsky O.Yu.
2024-11-01
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| Series: | Zdorovʹe Rebenka |
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| Online Access: | https://childshealth.zaslavsky.com.ua/index.php/journal/article/view/1758 |
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| author | H.V. Beketova O.O. Koiro S.S. Bohdanova M.S. Bulhakova K.M. Heorhitsa O.B. Il’kiv О.R. Kavka О.Z. Kmit’ О.V. Kukhar V.І. Liubetska V.V. Maleiko І.А. Matiukhina К.О. Medvedska N.B. Pavchak К.А. Percheklii V.V. Semenchuk Y.О. Sotnichenko U.М. Tomashiuk N.І. Tsvynda М.Y. Shalimanova |
| author_facet | H.V. Beketova O.O. Koiro S.S. Bohdanova M.S. Bulhakova K.M. Heorhitsa O.B. Il’kiv О.R. Kavka О.Z. Kmit’ О.V. Kukhar V.І. Liubetska V.V. Maleiko І.А. Matiukhina К.О. Medvedska N.B. Pavchak К.А. Percheklii V.V. Semenchuk Y.О. Sotnichenko U.М. Tomashiuk N.І. Tsvynda М.Y. Shalimanova |
| author_sort | H.V. Beketova |
| collection | DOAJ |
| description | The effectiveness of the probiotic strain Bacillus clausii UBBC-07, was evaluated in the prevention of antibiotic-associated diarrhea. The study analyzed the treatment outcomes of 939 patients aged 28 days to 18 years with bacterial infections of various localizations, receiving systemic antibacterial therapy. Patients who took Bacillus clausii UBBC-07 simultaneously with antibiotics (n = 671) were assigned to the treatment group, while those who did not receive the probiotic on the background of antibiotic therapy (n = 268) were included in the control group. The treatment outcomes were evaluated in 794 patients (565 from the treatment group and 229 controls), for whom the prescribed antibacterial agent was known. In the treatment group, there was a significantly lower incidence of gastrointestinal disturbances compared to the control group, specifically diarrhea (5.5 vs. 14.0 %) and abdominal pain (3.7 vs. 7.4 %). Prophylactic use of the probiotic reduced the frequency of developing antibiotic-associated diarrhea in general by 2.5 times, with a reduction of 2.5 times among patients receiving penicillins, of 2.4 times among those treated with cephalosporins, and of 5.1 times for those who took macrolides. Bacillus clausii UBBC-07 also decreased the duration of loose stools in patients with diarrhea (1.84 days in the treatment group vs. 2.66 days in the control one) and the average number of days with abdominal pain in those who reported discomfort (1.25 vs. 1.71 days, respectively). Thus, the use of Bacillus clausii UBBC-07 from the first day of antibacterial therapy in children contributes to the effective prevention of antibiotic-associated diarrhea, significantly improving patients’ quality of life, accelerating their recovery, and reducing the likelihood of complications. |
| format | Article |
| id | doaj-art-c675805aed1b49ff8f3fb83717c5a91e |
| institution | Kabale University |
| issn | 2224-0551 2307-1168 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Zdorovʹe Rebenka |
| spelling | doaj-art-c675805aed1b49ff8f3fb83717c5a91e2025-01-12T11:28:26ZengZaslavsky O.Yu.Zdorovʹe Rebenka2224-05512307-11682024-11-0119745446310.22141/2224-0551.19.7.2024.17581758Efficacy of Bacillus clausii UBBC-07 in the prevention of antibiotic-associated diarrhea in childrenH.V. Beketova0https://orcid.org/0000-0002-8400-4580O.O. Koiro1https://orcid.org/0000-0002-6190-4041S.S. Bohdanova2M.S. Bulhakova3K.M. Heorhitsa4O.B. Il’kiv5О.R. Kavka6О.Z. Kmit’7О.V. Kukhar8V.І. Liubetska9V.V. Maleiko10І.А. Matiukhina11К.О. Medvedska12N.B. Pavchak13К.А. Percheklii14V.V. Semenchuk15Y.О. Sotnichenko16U.М. Tomashiuk17N.І. Tsvynda18М.Y. Shalimanova19Shupyk National Healthcare University of Ukraine, Kyiv, UkraineNational University of Pharmacy, Kharkiv, UkraineMunicipal Non-Commercial Enterprise “Children’s City Polyclinic 6” of the Odesa City Council, Odesa, UkraineMedical Center “Healthy Nation”, Dnipro, UkraineOutpatient Clinic 4 of the Dnipro Primary Health Care Center 10, Dnipro, UkrainePolyclinic of the Pustomyty Central District Hospital, Pustomyty, Lviv Region, UkraineMunicipal Non-Commercial Enterprise “City Polyclinic 2”, Lviv, UkrainePolyclinic of the Mostyska Communal Central District Hospital, Mostyska, Lviv Region, UkraineChildren’s City Polyclinic 5, Odesa, UkraineChildren’s City Polyclinic 5, Odesa, UkraineOutpatient Clinic 2 of the Primary Health Care Center 3, Vinnytsia, UkraineMunicipal Non-Commercial Enterprise “Children’s Polyclinic of the Chornomorsk Hospital”, Chornomorsk, Odesa Region, UkraineOutpatient Clinic of General Practice — Family Medicine, Stryzhavka, Vinnytsia Region, UkrainePolyclinic of the Horodenka Central District Hospital, Horodenka, Ivano-Frankivsk Region, UkraineChildren’s City Polyclinic 6, Odesa, UkraineUlaniv District Hospital of the Khmilnyk Central District Hospital, Ulaniv, Vinnytsia Region, UkraineChernihiv City Family Polyclinic 2, Chernihiv, UkraineBranch of the Chernivtsi City Children’s Polyclinic, Chernivtsi, UkrainePolyclinic of the Uman Children’s City Hospital, Uman, Cherkasy Region, UkraineMunicipal Non-Commercial Enterprise “Cherkasy Primary Health Care Center 1”, Cherkasy, UkraineThe effectiveness of the probiotic strain Bacillus clausii UBBC-07, was evaluated in the prevention of antibiotic-associated diarrhea. The study analyzed the treatment outcomes of 939 patients aged 28 days to 18 years with bacterial infections of various localizations, receiving systemic antibacterial therapy. Patients who took Bacillus clausii UBBC-07 simultaneously with antibiotics (n = 671) were assigned to the treatment group, while those who did not receive the probiotic on the background of antibiotic therapy (n = 268) were included in the control group. The treatment outcomes were evaluated in 794 patients (565 from the treatment group and 229 controls), for whom the prescribed antibacterial agent was known. In the treatment group, there was a significantly lower incidence of gastrointestinal disturbances compared to the control group, specifically diarrhea (5.5 vs. 14.0 %) and abdominal pain (3.7 vs. 7.4 %). Prophylactic use of the probiotic reduced the frequency of developing antibiotic-associated diarrhea in general by 2.5 times, with a reduction of 2.5 times among patients receiving penicillins, of 2.4 times among those treated with cephalosporins, and of 5.1 times for those who took macrolides. Bacillus clausii UBBC-07 also decreased the duration of loose stools in patients with diarrhea (1.84 days in the treatment group vs. 2.66 days in the control one) and the average number of days with abdominal pain in those who reported discomfort (1.25 vs. 1.71 days, respectively). Thus, the use of Bacillus clausii UBBC-07 from the first day of antibacterial therapy in children contributes to the effective prevention of antibiotic-associated diarrhea, significantly improving patients’ quality of life, accelerating their recovery, and reducing the likelihood of complications.https://childshealth.zaslavsky.com.ua/index.php/journal/article/view/1758antibiotic-associated diarrheaprobiotics-bioenterosepticsbacillus clausii ubbc-07 |
| spellingShingle | H.V. Beketova O.O. Koiro S.S. Bohdanova M.S. Bulhakova K.M. Heorhitsa O.B. Il’kiv О.R. Kavka О.Z. Kmit’ О.V. Kukhar V.І. Liubetska V.V. Maleiko І.А. Matiukhina К.О. Medvedska N.B. Pavchak К.А. Percheklii V.V. Semenchuk Y.О. Sotnichenko U.М. Tomashiuk N.І. Tsvynda М.Y. Shalimanova Efficacy of Bacillus clausii UBBC-07 in the prevention of antibiotic-associated diarrhea in children Zdorovʹe Rebenka antibiotic-associated diarrhea probiotics-bioenteroseptics bacillus clausii ubbc-07 |
| title | Efficacy of Bacillus clausii UBBC-07 in the prevention of antibiotic-associated diarrhea in children |
| title_full | Efficacy of Bacillus clausii UBBC-07 in the prevention of antibiotic-associated diarrhea in children |
| title_fullStr | Efficacy of Bacillus clausii UBBC-07 in the prevention of antibiotic-associated diarrhea in children |
| title_full_unstemmed | Efficacy of Bacillus clausii UBBC-07 in the prevention of antibiotic-associated diarrhea in children |
| title_short | Efficacy of Bacillus clausii UBBC-07 in the prevention of antibiotic-associated diarrhea in children |
| title_sort | efficacy of bacillus clausii ubbc 07 in the prevention of antibiotic associated diarrhea in children |
| topic | antibiotic-associated diarrhea probiotics-bioenteroseptics bacillus clausii ubbc-07 |
| url | https://childshealth.zaslavsky.com.ua/index.php/journal/article/view/1758 |
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