Neurofilament light chain plasma levels in major depressive disorder: a brief research report
IntroductionPeripheral neurofilament light chain (NfL) reflect neuronal and axonal damage. Most studies have been focused on NfL cerebrospinal fluid measures since peripheral levels were difficult to detect. However, with recent advent of single molecule array (SIMOA) technology, NfL is now detectab...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1476248/full |
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| author | Carlos Fernández-Pereira Carlos Fernández-Pereira Carlos Fernández-Pereira María de los Ángeles Fernández-Ceballos María de los Ángeles Fernández-Ceballos María de los Ángeles Fernández-Ceballos José Manuel Olivares José M. Prieto-González José M. Prieto-González José M. Prieto-González Roberto Carlos Agís-Balboa Roberto Carlos Agís-Balboa Roberto Carlos Agís-Balboa |
| author_facet | Carlos Fernández-Pereira Carlos Fernández-Pereira Carlos Fernández-Pereira María de los Ángeles Fernández-Ceballos María de los Ángeles Fernández-Ceballos María de los Ángeles Fernández-Ceballos José Manuel Olivares José M. Prieto-González José M. Prieto-González José M. Prieto-González Roberto Carlos Agís-Balboa Roberto Carlos Agís-Balboa Roberto Carlos Agís-Balboa |
| author_sort | Carlos Fernández-Pereira |
| collection | DOAJ |
| description | IntroductionPeripheral neurofilament light chain (NfL) reflect neuronal and axonal damage. Most studies have been focused on NfL cerebrospinal fluid measures since peripheral levels were difficult to detect. However, with recent advent of single molecule array (SIMOA) technology, NfL is now detectable peripherally at small concentrations (pg/ml). In neurodegenerative disorders, NfL peripheral levels have been found significantly elevated compared against psychiatric disorders. However, there is still controversy of whether NfL peripheral levels might be altered in psychiatric disorders like major depressive disorder (MDD) when compared against a normal population.MethodsWe have measured NfL plasma levels by using single molecule array (SIMOA) technology in a Spanish small cohort of MDD patients (n = 15) and a HC group (n = 15). We have used subjective scales to estimate depression severity (HDRS), anhedonia (SAAS), the general cognitive state (MMSE) and episodic memory (FCSRT) in MDD patients.ResultsWe have not detected a significant alteration in NfL plasma levels in MDD patients when compared against the HC subjects (U = 97, p-value = 0.532). Moreover, we have not detected any significant correlation between NfL plasma levels with any subjective scales. The only parameter that significantly and positively correlated with NfL plasma levels was age in both MDD and HC.DiscussionSignificant alteration in NfL plasma levels in MDD patients might reflect neurobiological changes behind the predisposition to develop future neurodegenerative disorders such as Alzheimer’s or Parkinson’s diseases for which depression represents a risk factor. However, whether there is an increase in NfL due to MDD regardless of the ageing process is still a matter of debate. |
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| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-c674875f362a411d83e39aa7673520612024-11-14T06:21:20ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402024-11-011510.3389/fpsyt.2024.14762481476248Neurofilament light chain plasma levels in major depressive disorder: a brief research reportCarlos Fernández-Pereira0Carlos Fernández-Pereira1Carlos Fernández-Pereira2María de los Ángeles Fernández-Ceballos3María de los Ángeles Fernández-Ceballos4María de los Ángeles Fernández-Ceballos5José Manuel Olivares6José M. Prieto-González7José M. Prieto-González8José M. Prieto-González9Roberto Carlos Agís-Balboa10Roberto Carlos Agís-Balboa11Roberto Carlos Agís-Balboa12Translational Neuroscience Group, Galicia Sur Health Research Institute (IIS-Galicia Sur), Área Sanitaria de Vigo-Hospital Álvaro Cunqueiro, SERGAS-UVIGO, CIBERSAM-ISCII, Vigo, SpainNeuroEpigenetics Lab, Health Research Institute of Santiago of Compostela (IDIS), Santiago University Hospital Complex, Santiago de Compostela, SpainTransalational Research in Neurological Diseases Group (ITEN), Health Research Institute of Santiago de Compostela (IDIS), Santiago University Complex, SERGAS-USC, Santiago de Compostela, SpainNeuroEpigenetics Lab, Health Research Institute of Santiago of Compostela (IDIS), Santiago University Hospital Complex, Santiago de Compostela, SpainTransalational Research in Neurological Diseases Group (ITEN), Health Research Institute of Santiago de Compostela (IDIS), Santiago University Complex, SERGAS-USC, Santiago de Compostela, SpainNeurology Service, Santiago University Hospital Complex, Santiago de Compostela, SpainTranslational Neuroscience Group, Galicia Sur Health Research Institute (IIS-Galicia Sur), Área Sanitaria de Vigo-Hospital Álvaro Cunqueiro, SERGAS-UVIGO, CIBERSAM-ISCII, Vigo, SpainNeuroEpigenetics Lab, Health Research Institute of Santiago of Compostela (IDIS), Santiago University Hospital Complex, Santiago de Compostela, SpainTransalational Research in Neurological Diseases Group (ITEN), Health Research Institute of Santiago de Compostela (IDIS), Santiago University Complex, SERGAS-USC, Santiago de Compostela, SpainNeurology Service, Santiago University Hospital Complex, Santiago de Compostela, SpainNeuroEpigenetics Lab, Health Research Institute of Santiago of Compostela (IDIS), Santiago University Hospital Complex, Santiago de Compostela, SpainTransalational Research in Neurological Diseases Group (ITEN), Health Research Institute of Santiago de Compostela (IDIS), Santiago University Complex, SERGAS-USC, Santiago de Compostela, SpainNeurology Service, Santiago University Hospital Complex, Santiago de Compostela, SpainIntroductionPeripheral neurofilament light chain (NfL) reflect neuronal and axonal damage. Most studies have been focused on NfL cerebrospinal fluid measures since peripheral levels were difficult to detect. However, with recent advent of single molecule array (SIMOA) technology, NfL is now detectable peripherally at small concentrations (pg/ml). In neurodegenerative disorders, NfL peripheral levels have been found significantly elevated compared against psychiatric disorders. However, there is still controversy of whether NfL peripheral levels might be altered in psychiatric disorders like major depressive disorder (MDD) when compared against a normal population.MethodsWe have measured NfL plasma levels by using single molecule array (SIMOA) technology in a Spanish small cohort of MDD patients (n = 15) and a HC group (n = 15). We have used subjective scales to estimate depression severity (HDRS), anhedonia (SAAS), the general cognitive state (MMSE) and episodic memory (FCSRT) in MDD patients.ResultsWe have not detected a significant alteration in NfL plasma levels in MDD patients when compared against the HC subjects (U = 97, p-value = 0.532). Moreover, we have not detected any significant correlation between NfL plasma levels with any subjective scales. The only parameter that significantly and positively correlated with NfL plasma levels was age in both MDD and HC.DiscussionSignificant alteration in NfL plasma levels in MDD patients might reflect neurobiological changes behind the predisposition to develop future neurodegenerative disorders such as Alzheimer’s or Parkinson’s diseases for which depression represents a risk factor. However, whether there is an increase in NfL due to MDD regardless of the ageing process is still a matter of debate.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1476248/fullneurofilament light chainmajor depressive disorderplasmacognitionanhedonia; memorypsychiatry |
| spellingShingle | Carlos Fernández-Pereira Carlos Fernández-Pereira Carlos Fernández-Pereira María de los Ángeles Fernández-Ceballos María de los Ángeles Fernández-Ceballos María de los Ángeles Fernández-Ceballos José Manuel Olivares José M. Prieto-González José M. Prieto-González José M. Prieto-González Roberto Carlos Agís-Balboa Roberto Carlos Agís-Balboa Roberto Carlos Agís-Balboa Neurofilament light chain plasma levels in major depressive disorder: a brief research report Frontiers in Psychiatry neurofilament light chain major depressive disorder plasma cognition anhedonia; memory psychiatry |
| title | Neurofilament light chain plasma levels in major depressive disorder: a brief research report |
| title_full | Neurofilament light chain plasma levels in major depressive disorder: a brief research report |
| title_fullStr | Neurofilament light chain plasma levels in major depressive disorder: a brief research report |
| title_full_unstemmed | Neurofilament light chain plasma levels in major depressive disorder: a brief research report |
| title_short | Neurofilament light chain plasma levels in major depressive disorder: a brief research report |
| title_sort | neurofilament light chain plasma levels in major depressive disorder a brief research report |
| topic | neurofilament light chain major depressive disorder plasma cognition anhedonia; memory psychiatry |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1476248/full |
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