Population pharmacokinetics of high-dose methotrexate in patients with primary central nervous system lymphoma

Population pharmacokinetics of high-dose methotrexate in patients with primary central nervous system lymphoma

ObjectiveMethotrexate (MTX) serves as a cornerstone therapy for primary central nervous system lymphoma (PCNSL). However, the considerable intra- and inter-individual variability in its pharmacokinetic and therapeutic efficacy poses significant challenges to clinical application. This study aims to...

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Bibliographic Details
Main Authors: Shifeng Wei, Sitian Zhang, Dan Wang, Dongjie Zhang, Qian Lu, Jiayi Mo, Zhilin Yang, Leyi Guan, Yingjun He, Zhigang Zhao, Shenghui Mei
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
methotrexate
primary central nervous system lymphoma
population pharmacokinetic model
nonlinear mixed-effects modeling
estimated glomerular filtration rate
blood urea nitrogen
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1578033/full
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