Cell-free DNA Levels in Herpes Zoster: A Cross-sectional Longitudinal Study
This study investigates serum cell-free DNA fluctuations in patients with herpes zoster or post-herpetic neuralgia, offering insight into the tissue damage and inflammatory dynamics associated with these conditions. A single-centre combined cross-sectional and longitudinal study was conducted with 5...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2025-01-01
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| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: | https://medicaljournalssweden.se/actadv/article/view/42137 |
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| author | Chaya Bracha Gordon Yaron Zenaty Ayelet Ollech Gidon Test Amos Douvdevani Amir Horev |
| author_facet | Chaya Bracha Gordon Yaron Zenaty Ayelet Ollech Gidon Test Amos Douvdevani Amir Horev |
| author_sort | Chaya Bracha Gordon |
| collection | DOAJ |
| description | This study investigates serum cell-free DNA fluctuations in patients with herpes zoster or post-herpetic neuralgia, offering insight into the tissue damage and inflammatory dynamics associated with these conditions. A single-centre combined cross-sectional and longitudinal study was conducted with 59 patients to assess cell-free DNA levels in herpes zoster and post-herpetic neuralgia. Cell-free DNA was extracted from blood samples of patients with herpes zoster or post-herpetic neuralgia and compared with healthy controls. The findings demonstrated elevated cell-free DNA levels in patients with herpes zoster, which remained elevated for 3 months or longer following treat-ment. These results suggest the presence of a subacute inflammatory state after herpes zoster infection. Furthermore, patients who developed post-herpetic neuralgia did not show elevated cell-free DNA levels, while those who did not develop post-herpetic neuralgia exhibited increased levels. This indicates that post-herpetic neuralgia is likely a localized response to prior nerve damage rather than a systemic inflammatory process with acute tissue damage.
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| format | Article |
| id | doaj-art-c6238c6b622d45ebaba14c97dfd182c6 |
| institution | Kabale University |
| issn | 0001-5555 1651-2057 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj-art-c6238c6b622d45ebaba14c97dfd182c62025-01-03T08:46:02ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572025-01-0110510.2340/actadv.v105.42137Cell-free DNA Levels in Herpes Zoster: A Cross-sectional Longitudinal StudyChaya Bracha Gordon0Yaron Zenaty1Ayelet Ollech2Gidon Test3Amos Douvdevani4Amir Horev5Ben Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, IsraelBen Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, IsraelPediatric Dermatology Service, Shaare Zedek Medical Center, Jerusalem, Israel; Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel4Pediatric Emergency Department, Soroka University Medical Center, Beer-Sheva, Israel Ben Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, Israel; Department of Clinical Biochemistry, Soroka Medical Center, Beer-Sheva, IsraelBen Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, Israel; Pediatric Dermatology Service, Soroka University Medical Center, Beer-Sheva, IsraelThis study investigates serum cell-free DNA fluctuations in patients with herpes zoster or post-herpetic neuralgia, offering insight into the tissue damage and inflammatory dynamics associated with these conditions. A single-centre combined cross-sectional and longitudinal study was conducted with 59 patients to assess cell-free DNA levels in herpes zoster and post-herpetic neuralgia. Cell-free DNA was extracted from blood samples of patients with herpes zoster or post-herpetic neuralgia and compared with healthy controls. The findings demonstrated elevated cell-free DNA levels in patients with herpes zoster, which remained elevated for 3 months or longer following treat-ment. These results suggest the presence of a subacute inflammatory state after herpes zoster infection. Furthermore, patients who developed post-herpetic neuralgia did not show elevated cell-free DNA levels, while those who did not develop post-herpetic neuralgia exhibited increased levels. This indicates that post-herpetic neuralgia is likely a localized response to prior nerve damage rather than a systemic inflammatory process with acute tissue damage. https://medicaljournalssweden.se/actadv/article/view/42137herpes zosterpost-herpetic neuralgiahuman herpes viruscell-free DNAinflammation marker. |
| spellingShingle | Chaya Bracha Gordon Yaron Zenaty Ayelet Ollech Gidon Test Amos Douvdevani Amir Horev Cell-free DNA Levels in Herpes Zoster: A Cross-sectional Longitudinal Study Acta Dermato-Venereologica herpes zoster post-herpetic neuralgia human herpes virus cell-free DNA inflammation marker. |
| title | Cell-free DNA Levels in Herpes Zoster: A Cross-sectional Longitudinal Study |
| title_full | Cell-free DNA Levels in Herpes Zoster: A Cross-sectional Longitudinal Study |
| title_fullStr | Cell-free DNA Levels in Herpes Zoster: A Cross-sectional Longitudinal Study |
| title_full_unstemmed | Cell-free DNA Levels in Herpes Zoster: A Cross-sectional Longitudinal Study |
| title_short | Cell-free DNA Levels in Herpes Zoster: A Cross-sectional Longitudinal Study |
| title_sort | cell free dna levels in herpes zoster a cross sectional longitudi nal study |
| topic | herpes zoster post-herpetic neuralgia human herpes virus cell-free DNA inflammation marker. |
| url | https://medicaljournalssweden.se/actadv/article/view/42137 |
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