Global, regional, and national burden inequality of chronic kidney disease, 1990–2021: a systematic analysis for the global burden of disease study 2021
BackgroundChronic kidney disease (CKD) is a significant global health issue, often linked to diabetes, hypertension, and glomerulonephritis. However, aggregated statistics can obscure heterogeneity across subtypes, age, gender, and regions. This study aimed to analyze global CKD trends from 1990 to...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1501175/full |
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| author | Jingxun Guo Jingxun Guo Zhen Liu Zhen Liu Pengjun Wang Heming Wu Kai Fan Kai Fan Jianbo Jin Jianbo Jin Lan Zheng Lan Zheng Zeyu Liu Zeyu Liu Renyi Xie Renyi Xie Renyi Xie Cheng Li Cheng Li Cheng Li Cheng Li |
| author_facet | Jingxun Guo Jingxun Guo Zhen Liu Zhen Liu Pengjun Wang Heming Wu Kai Fan Kai Fan Jianbo Jin Jianbo Jin Lan Zheng Lan Zheng Zeyu Liu Zeyu Liu Renyi Xie Renyi Xie Renyi Xie Cheng Li Cheng Li Cheng Li Cheng Li |
| author_sort | Jingxun Guo |
| collection | DOAJ |
| description | BackgroundChronic kidney disease (CKD) is a significant global health issue, often linked to diabetes, hypertension, and glomerulonephritis. However, aggregated statistics can obscure heterogeneity across subtypes, age, gender, and regions. This study aimed to analyze global CKD trends from 1990 to 2021, focusing on age, gender, socio-demographic index (SDI), and regional variations.MethodsData were extracted from the Global Burden of Disease (GBD) 2021 database, covering prevalence, incidence, mortality, and disability-adjusted life years (DALYs). These were presented as counts per 100,000 population and age-standardized rates, with uncertainty intervals (UIs) to highlight variability. Joinpoint regression was used to assess trends over the 30-year period.ResultsIn 2021, global CKD prevalence was 359 million, with 11.13 million new cases, 1.53 million deaths, and 44.45 million DALYs—up 92, 156, 176, and 114% since 1990. While prevalence slightly declined, incidence, mortality, and DALYs increased significantly. CKD burden varied by region and age, with notable gender disparities.ConclusionThe study highlights a dramatic rise in CKD burden linked to population growth and aging, emphasizing the need for targeted treatment and effective global healthcare policies. |
| format | Article |
| id | doaj-art-c60e95abd7be4ce8a9e3304555a8f3b4 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-c60e95abd7be4ce8a9e3304555a8f3b42025-01-15T06:10:44ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.15011751501175Global, regional, and national burden inequality of chronic kidney disease, 1990–2021: a systematic analysis for the global burden of disease study 2021Jingxun Guo0Jingxun Guo1Zhen Liu2Zhen Liu3Pengjun Wang4Heming Wu5Kai Fan6Kai Fan7Jianbo Jin8Jianbo Jin9Lan Zheng10Lan Zheng11Zeyu Liu12Zeyu Liu13Renyi Xie14Renyi Xie15Renyi Xie16Cheng Li17Cheng Li18Cheng Li19Cheng Li20Eye Institute and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaFujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Diseases, Xiamen, Fujian, ChinaEye Institute and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaFujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Diseases, Xiamen, Fujian, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, ChinaDepartment of Basic Medical Sciences, School of Medicine, Xiamen University, Xiamen, ChinaEye Institute and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaFujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Diseases, Xiamen, Fujian, ChinaEye Institute and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaFujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Diseases, Xiamen, Fujian, ChinaEye Institute and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaFujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Diseases, Xiamen, Fujian, ChinaEye Institute and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaFujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Diseases, Xiamen, Fujian, ChinaEye Institute and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaXiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, ChinaEye Institute and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaEye Institute and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaFujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Diseases, Xiamen, Fujian, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, ChinaHuaxia Eye Hospital of Quanzhou, Quanzhou, Fujian, ChinaBackgroundChronic kidney disease (CKD) is a significant global health issue, often linked to diabetes, hypertension, and glomerulonephritis. However, aggregated statistics can obscure heterogeneity across subtypes, age, gender, and regions. This study aimed to analyze global CKD trends from 1990 to 2021, focusing on age, gender, socio-demographic index (SDI), and regional variations.MethodsData were extracted from the Global Burden of Disease (GBD) 2021 database, covering prevalence, incidence, mortality, and disability-adjusted life years (DALYs). These were presented as counts per 100,000 population and age-standardized rates, with uncertainty intervals (UIs) to highlight variability. Joinpoint regression was used to assess trends over the 30-year period.ResultsIn 2021, global CKD prevalence was 359 million, with 11.13 million new cases, 1.53 million deaths, and 44.45 million DALYs—up 92, 156, 176, and 114% since 1990. While prevalence slightly declined, incidence, mortality, and DALYs increased significantly. CKD burden varied by region and age, with notable gender disparities.ConclusionThe study highlights a dramatic rise in CKD burden linked to population growth and aging, emphasizing the need for targeted treatment and effective global healthcare policies.https://www.frontiersin.org/articles/10.3389/fmed.2024.1501175/fullchronic kidney diseaseglobal burden of diseaseprevalenceincidencemortalitydisability-adjusted life years |
| spellingShingle | Jingxun Guo Jingxun Guo Zhen Liu Zhen Liu Pengjun Wang Heming Wu Kai Fan Kai Fan Jianbo Jin Jianbo Jin Lan Zheng Lan Zheng Zeyu Liu Zeyu Liu Renyi Xie Renyi Xie Renyi Xie Cheng Li Cheng Li Cheng Li Cheng Li Global, regional, and national burden inequality of chronic kidney disease, 1990–2021: a systematic analysis for the global burden of disease study 2021 Frontiers in Medicine chronic kidney disease global burden of disease prevalence incidence mortality disability-adjusted life years |
| title | Global, regional, and national burden inequality of chronic kidney disease, 1990–2021: a systematic analysis for the global burden of disease study 2021 |
| title_full | Global, regional, and national burden inequality of chronic kidney disease, 1990–2021: a systematic analysis for the global burden of disease study 2021 |
| title_fullStr | Global, regional, and national burden inequality of chronic kidney disease, 1990–2021: a systematic analysis for the global burden of disease study 2021 |
| title_full_unstemmed | Global, regional, and national burden inequality of chronic kidney disease, 1990–2021: a systematic analysis for the global burden of disease study 2021 |
| title_short | Global, regional, and national burden inequality of chronic kidney disease, 1990–2021: a systematic analysis for the global burden of disease study 2021 |
| title_sort | global regional and national burden inequality of chronic kidney disease 1990 2021 a systematic analysis for the global burden of disease study 2021 |
| topic | chronic kidney disease global burden of disease prevalence incidence mortality disability-adjusted life years |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1501175/full |
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