Local changes in potassium ions regulate input integration in active dendrites.
During neuronal activity, the extracellular concentration of potassium ions ([K+]o) increases substantially above resting levels, yet it remains unclear what role these [K+]o changes play in the dendritic integration of synaptic inputs. We here used mathematical formulations and biophysical modeling...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-12-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3002935 |
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| author | Malthe S Nordentoft Naoya Takahashi Mathias S Heltberg Mogens H Jensen Rune N Rasmussen Athanasia Papoutsi |
| author_facet | Malthe S Nordentoft Naoya Takahashi Mathias S Heltberg Mogens H Jensen Rune N Rasmussen Athanasia Papoutsi |
| author_sort | Malthe S Nordentoft |
| collection | DOAJ |
| description | During neuronal activity, the extracellular concentration of potassium ions ([K+]o) increases substantially above resting levels, yet it remains unclear what role these [K+]o changes play in the dendritic integration of synaptic inputs. We here used mathematical formulations and biophysical modeling to explore the role of synaptic activity-dependent K+ changes in dendritic segments of a visual cortex pyramidal neuron, receiving inputs tuned to stimulus orientation. We found that the spatial arrangement of inputs dictates the magnitude of [K+]o changes in the dendrites: Dendritic segments receiving similarly tuned inputs can attain substantially higher [K+]o increases than segments receiving diversely tuned inputs. These [K+]o elevations in turn increase dendritic excitability, leading to more robust and prolonged dendritic spikes. Ultimately, these local effects amplify the gain of neuronal input-output transformations, causing higher orientation-tuned somatic firing rates without compromising orientation selectivity. Our results suggest that local, activity-dependent [K+]o changes in dendrites may act as a "volume knob" that determines the impact of synaptic inputs on feature-tuned neuronal firing. |
| format | Article |
| id | doaj-art-c60d0dbb7b614c4199f26a5b6595b80d |
| institution | Kabale University |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-c60d0dbb7b614c4199f26a5b6595b80d2025-01-08T05:30:24ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852024-12-012212e300293510.1371/journal.pbio.3002935Local changes in potassium ions regulate input integration in active dendrites.Malthe S NordentoftNaoya TakahashiMathias S HeltbergMogens H JensenRune N RasmussenAthanasia PapoutsiDuring neuronal activity, the extracellular concentration of potassium ions ([K+]o) increases substantially above resting levels, yet it remains unclear what role these [K+]o changes play in the dendritic integration of synaptic inputs. We here used mathematical formulations and biophysical modeling to explore the role of synaptic activity-dependent K+ changes in dendritic segments of a visual cortex pyramidal neuron, receiving inputs tuned to stimulus orientation. We found that the spatial arrangement of inputs dictates the magnitude of [K+]o changes in the dendrites: Dendritic segments receiving similarly tuned inputs can attain substantially higher [K+]o increases than segments receiving diversely tuned inputs. These [K+]o elevations in turn increase dendritic excitability, leading to more robust and prolonged dendritic spikes. Ultimately, these local effects amplify the gain of neuronal input-output transformations, causing higher orientation-tuned somatic firing rates without compromising orientation selectivity. Our results suggest that local, activity-dependent [K+]o changes in dendrites may act as a "volume knob" that determines the impact of synaptic inputs on feature-tuned neuronal firing.https://doi.org/10.1371/journal.pbio.3002935 |
| spellingShingle | Malthe S Nordentoft Naoya Takahashi Mathias S Heltberg Mogens H Jensen Rune N Rasmussen Athanasia Papoutsi Local changes in potassium ions regulate input integration in active dendrites. PLoS Biology |
| title | Local changes in potassium ions regulate input integration in active dendrites. |
| title_full | Local changes in potassium ions regulate input integration in active dendrites. |
| title_fullStr | Local changes in potassium ions regulate input integration in active dendrites. |
| title_full_unstemmed | Local changes in potassium ions regulate input integration in active dendrites. |
| title_short | Local changes in potassium ions regulate input integration in active dendrites. |
| title_sort | local changes in potassium ions regulate input integration in active dendrites |
| url | https://doi.org/10.1371/journal.pbio.3002935 |
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