Association of the Preoperative Controlling Nutritional Status (CONUT) Score with Clinicopathological Characteristics in Patients with Papillary Thyroid Carcinoma
Background The Controlling Nutritional Status (CONUT) score is an immunonutritional test tool based on serum albumin, total cholesterol, and lymphocyte counts. It has been studied as a simple prognostic predictor for various carcinomas. This study aimed to investigate the association between preoper...
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Korean Endocrine Society
2024-12-01
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| Series: | Endocrinology and Metabolism |
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| Online Access: | http://www.e-enm.org/upload/pdf/enm-2024-2006.pdf |
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| author | Doohwa Kim Myungsoo Im Soree Ryang Mijin Kim Yun Kyung Jeon Sang Soo Kim Bo Hyun Kim |
| author_facet | Doohwa Kim Myungsoo Im Soree Ryang Mijin Kim Yun Kyung Jeon Sang Soo Kim Bo Hyun Kim |
| author_sort | Doohwa Kim |
| collection | DOAJ |
| description | Background The Controlling Nutritional Status (CONUT) score is an immunonutritional test tool based on serum albumin, total cholesterol, and lymphocyte counts. It has been studied as a simple prognostic predictor for various carcinomas. This study aimed to investigate the association between preoperative CONUT scores and the clinicopathological characteristics in papillary thyroid carcinoma (PTC) patients. Methods This study included 2,403 PTC patients who underwent total thyroidectomy between 2012 and 2016 at a single tertiary medical center. The CONUT scores were calculated based on preoperative blood tests. The clinicopathological characteristics were retrospectively reviewed. The patients were categorized by the CONUT score (relatively low, 0–2; relatively high, 3–5). Results Among the 2,997 PTC patients who underwent total thyroidectomy at Pusan National University Hospital between 2012 and 2016, those without preoperative blood test were excluded (n=149). Finally 2,403 patients were analyzed after excluding 439 patients taking lipid-lowering drugs and six patients without available T stage data after surgery. Based on the CONUT score, the relatively high score group had a lower body mass index (23.7±3.3 kg/m2 vs. 21.9±2.9 kg/m2, P<0.001), more advanced T stage (T stage 3/4, 5.9% vs. 11.4%, P=0.045), and higher extrathyroidal extension (2.1% vs. 7.6%, P=0.005). Conclusion Patients included in this large, single-center study all had a preoperative CONUT score of 0–5, but this study demonstrated that higher preoperative CONUT scores were significantly associated with advanced T stage and extrathyroidal extension. The CONUT score, which can be easily used in clinical practice, is thought to be helpful in predicting the aggressiveness of PTC. |
| format | Article |
| id | doaj-art-c5fe235ce5e64c91b8f6bdcbc1f4dae4 |
| institution | Kabale University |
| issn | 2093-596X 2093-5978 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj-art-c5fe235ce5e64c91b8f6bdcbc1f4dae42025-01-03T05:15:26ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782024-12-0139685686310.3803/EnM.2024.20062548Association of the Preoperative Controlling Nutritional Status (CONUT) Score with Clinicopathological Characteristics in Patients with Papillary Thyroid CarcinomaDoohwa Kim0Myungsoo Im1Soree Ryang2Mijin Kim3Yun Kyung Jeon4Sang Soo Kim5Bo Hyun Kim6 Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Korea Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Korea Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Korea Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Korea Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Korea Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Korea Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, KoreaBackground The Controlling Nutritional Status (CONUT) score is an immunonutritional test tool based on serum albumin, total cholesterol, and lymphocyte counts. It has been studied as a simple prognostic predictor for various carcinomas. This study aimed to investigate the association between preoperative CONUT scores and the clinicopathological characteristics in papillary thyroid carcinoma (PTC) patients. Methods This study included 2,403 PTC patients who underwent total thyroidectomy between 2012 and 2016 at a single tertiary medical center. The CONUT scores were calculated based on preoperative blood tests. The clinicopathological characteristics were retrospectively reviewed. The patients were categorized by the CONUT score (relatively low, 0–2; relatively high, 3–5). Results Among the 2,997 PTC patients who underwent total thyroidectomy at Pusan National University Hospital between 2012 and 2016, those without preoperative blood test were excluded (n=149). Finally 2,403 patients were analyzed after excluding 439 patients taking lipid-lowering drugs and six patients without available T stage data after surgery. Based on the CONUT score, the relatively high score group had a lower body mass index (23.7±3.3 kg/m2 vs. 21.9±2.9 kg/m2, P<0.001), more advanced T stage (T stage 3/4, 5.9% vs. 11.4%, P=0.045), and higher extrathyroidal extension (2.1% vs. 7.6%, P=0.005). Conclusion Patients included in this large, single-center study all had a preoperative CONUT score of 0–5, but this study demonstrated that higher preoperative CONUT scores were significantly associated with advanced T stage and extrathyroidal extension. The CONUT score, which can be easily used in clinical practice, is thought to be helpful in predicting the aggressiveness of PTC.http://www.e-enm.org/upload/pdf/enm-2024-2006.pdfconut scorethyroid cancer, papillarynutrition assessmentprognosis |
| spellingShingle | Doohwa Kim Myungsoo Im Soree Ryang Mijin Kim Yun Kyung Jeon Sang Soo Kim Bo Hyun Kim Association of the Preoperative Controlling Nutritional Status (CONUT) Score with Clinicopathological Characteristics in Patients with Papillary Thyroid Carcinoma Endocrinology and Metabolism conut score thyroid cancer, papillary nutrition assessment prognosis |
| title | Association of the Preoperative Controlling Nutritional Status (CONUT) Score with Clinicopathological Characteristics in Patients with Papillary Thyroid Carcinoma |
| title_full | Association of the Preoperative Controlling Nutritional Status (CONUT) Score with Clinicopathological Characteristics in Patients with Papillary Thyroid Carcinoma |
| title_fullStr | Association of the Preoperative Controlling Nutritional Status (CONUT) Score with Clinicopathological Characteristics in Patients with Papillary Thyroid Carcinoma |
| title_full_unstemmed | Association of the Preoperative Controlling Nutritional Status (CONUT) Score with Clinicopathological Characteristics in Patients with Papillary Thyroid Carcinoma |
| title_short | Association of the Preoperative Controlling Nutritional Status (CONUT) Score with Clinicopathological Characteristics in Patients with Papillary Thyroid Carcinoma |
| title_sort | association of the preoperative controlling nutritional status conut score with clinicopathological characteristics in patients with papillary thyroid carcinoma |
| topic | conut score thyroid cancer, papillary nutrition assessment prognosis |
| url | http://www.e-enm.org/upload/pdf/enm-2024-2006.pdf |
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