A literature review of drug transport mechanisms during lactation
Abstract Despite the benefits of breastfeeding, lactating mothers who take prescribed medications may discontinue breastfeeding due to concerns associated with infant drug exposure in breastmilk. Consolidating the current knowledge of drug transport to breastmilk may inform understanding of the safe...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-11-01
|
| Series: | CPT: Pharmacometrics & Systems Pharmacology |
| Online Access: | https://doi.org/10.1002/psp4.13195 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846162194231721984 |
|---|---|
| author | Christine Gong Lynn N. Bertagnolli David W. Boulton Paola Coppola |
| author_facet | Christine Gong Lynn N. Bertagnolli David W. Boulton Paola Coppola |
| author_sort | Christine Gong |
| collection | DOAJ |
| description | Abstract Despite the benefits of breastfeeding, lactating mothers who take prescribed medications may discontinue breastfeeding due to concerns associated with infant drug exposure in breastmilk. Consolidating the current knowledge of drug transport to breastmilk may inform understanding of the safety of medication use during lactation. This literature review summarizes the mechanisms of drug transport to breastmilk, details the physicochemical drug properties that may alter the extent of passive transport, and describes the expressional changes in mammary drug transporters that may affect active transport. During the period of 20 July 2023 to 11 August 2023, PubMed® was searched to identify journal articles pertinent to the mechanisms of drug transport from maternal plasma to breastmilk and the expression of mammary drug transporters during lactation. From the 28 studies included in this review, four mechanisms were identified for transporting drugs from maternal plasma to breastmilk: passive transport, active transport, lipid co‐transport, and transcytosis. The lactational expression of 20 drug transporters was further summarized, with 9 transporters demonstrating downregulated expression during lactation and 11 transporters demonstrating upregulated expression during lactation. Understanding the mechanisms of drug transport to breastmilk may aid in estimating infant drug exposure, developing physiologically based pharmacokinetic (PBPK) models that describe drug transfer, and initiating clinical drug development programs in the lactating population. |
| format | Article |
| id | doaj-art-c5fcf197f63a4f0a9d2e92fe10b1710d |
| institution | Kabale University |
| issn | 2163-8306 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | CPT: Pharmacometrics & Systems Pharmacology |
| spelling | doaj-art-c5fcf197f63a4f0a9d2e92fe10b1710d2024-11-20T17:18:44ZengWileyCPT: Pharmacometrics & Systems Pharmacology2163-83062024-11-0113111870188010.1002/psp4.13195A literature review of drug transport mechanisms during lactationChristine Gong0Lynn N. Bertagnolli1David W. Boulton2Paola Coppola3University of Pittsburgh School of Pharmacy Pittsburgh Pennsylvania USAClinical Pharmacology & Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences R&D, AstraZeneca LP Gaithersburg Maryland USAClinical Pharmacology & Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences R&D, AstraZeneca LP Gaithersburg Maryland USAClinical Pharmacology & Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences R&D Cambridge UKAbstract Despite the benefits of breastfeeding, lactating mothers who take prescribed medications may discontinue breastfeeding due to concerns associated with infant drug exposure in breastmilk. Consolidating the current knowledge of drug transport to breastmilk may inform understanding of the safety of medication use during lactation. This literature review summarizes the mechanisms of drug transport to breastmilk, details the physicochemical drug properties that may alter the extent of passive transport, and describes the expressional changes in mammary drug transporters that may affect active transport. During the period of 20 July 2023 to 11 August 2023, PubMed® was searched to identify journal articles pertinent to the mechanisms of drug transport from maternal plasma to breastmilk and the expression of mammary drug transporters during lactation. From the 28 studies included in this review, four mechanisms were identified for transporting drugs from maternal plasma to breastmilk: passive transport, active transport, lipid co‐transport, and transcytosis. The lactational expression of 20 drug transporters was further summarized, with 9 transporters demonstrating downregulated expression during lactation and 11 transporters demonstrating upregulated expression during lactation. Understanding the mechanisms of drug transport to breastmilk may aid in estimating infant drug exposure, developing physiologically based pharmacokinetic (PBPK) models that describe drug transfer, and initiating clinical drug development programs in the lactating population.https://doi.org/10.1002/psp4.13195 |
| spellingShingle | Christine Gong Lynn N. Bertagnolli David W. Boulton Paola Coppola A literature review of drug transport mechanisms during lactation CPT: Pharmacometrics & Systems Pharmacology |
| title | A literature review of drug transport mechanisms during lactation |
| title_full | A literature review of drug transport mechanisms during lactation |
| title_fullStr | A literature review of drug transport mechanisms during lactation |
| title_full_unstemmed | A literature review of drug transport mechanisms during lactation |
| title_short | A literature review of drug transport mechanisms during lactation |
| title_sort | literature review of drug transport mechanisms during lactation |
| url | https://doi.org/10.1002/psp4.13195 |
| work_keys_str_mv | AT christinegong aliteraturereviewofdrugtransportmechanismsduringlactation AT lynnnbertagnolli aliteraturereviewofdrugtransportmechanismsduringlactation AT davidwboulton aliteraturereviewofdrugtransportmechanismsduringlactation AT paolacoppola aliteraturereviewofdrugtransportmechanismsduringlactation AT christinegong literaturereviewofdrugtransportmechanismsduringlactation AT lynnnbertagnolli literaturereviewofdrugtransportmechanismsduringlactation AT davidwboulton literaturereviewofdrugtransportmechanismsduringlactation AT paolacoppola literaturereviewofdrugtransportmechanismsduringlactation |