EVALUATION OF GROWTH AND DEVELOPMENT OF RAT PUPS, PRENATALLY EXPOSED TO LAPROL-604
The article introduces findings of the study on surfactant-induced effects on the growth and maturation of rat pups, prenatally exposed to Laprol-604. The adverse influence of Laprol-604 exposure on rat fetuses was identified in the immediate postnatal period (0-3 days) and later. Laprol-604 induced...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Poltava State Medical University
2018-12-01
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| Series: | Проблеми екології та медицини |
| Subjects: | |
| Online Access: | https://ecomed-journal.org/index.php/journal/article/view/140 |
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| Summary: | The article introduces findings of the study on surfactant-induced effects on the growth and maturation of rat pups, prenatally exposed to Laprol-604. The adverse influence of Laprol-604 exposure on rat fetuses was identified in the immediate postnatal period (0-3 days) and later. Laprol-604 induced neonatal mortality within the period of three days, reduced litter size, resulted in low-birth-weight of progeny and a decrease in body weight gain in rat pups. Somatic growth retardation produced by Laprol-604 persisted during postnatal period and was accompanied by a delay in integumental morphogenesis of rat pups. Closer examination revealed an impact of Laprol-604 on delayed opening of the external auditory canal, resulting in an altered sequence of craniofacial development, such as the time of eyelid opening, incisor eruption. Maternal Laprol-604 exposure adversely affected the release and erection of the pinna. In summary, Laprol-604 had dosage-dependent developmental toxicity effect on progeny of female rats exposed to Laprol-604 during gestational period. |
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| ISSN: | 2073-4662 2519-2302 |