Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia
Background Depressive symptoms are often seen in schizophrenia. The overlap in presentation makes it difficult to distinguish depressive symptoms from the negative symptoms of schizophrenia. The adipokine leptin was found to be altered in both depression and schizophrenia. There are few studies focu...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2018-12-01
|
| Series: | General Psychiatry |
| Online Access: | https://gpsych.bmj.com/content/31/3/e100018.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846173773390151680 |
|---|---|
| author | Jinjie Xu Yumei Jiao Mengjuan Xing Yezhe Lin Yousong Su Wenhua Ding Cuizhen Zhu Yanmin Peng Dake Qi Donghong Cui |
| author_facet | Jinjie Xu Yumei Jiao Mengjuan Xing Yezhe Lin Yousong Su Wenhua Ding Cuizhen Zhu Yanmin Peng Dake Qi Donghong Cui |
| author_sort | Jinjie Xu |
| collection | DOAJ |
| description | Background Depressive symptoms are often seen in schizophrenia. The overlap in presentation makes it difficult to distinguish depressive symptoms from the negative symptoms of schizophrenia. The adipokine leptin was found to be altered in both depression and schizophrenia. There are few studies focusing on the prediction of leptin in diagnosis and evaluation of depressive symptoms in schizophrenia.ObjectiveAims To assess the plasma leptin level in patients with schizophrenia and its relationships with depressive symptoms.Methods Cross-sectional studies were applied to (1) compare the levels of plasma leptin between schizophrenia (n=74) and healthy controls (n=50); and (2) investigate the relationship between plasma leptin levels and depressive subscores.Results (1) Plasma leptin levels were significantly higher in patients with schizophrenia than in healthy controls. (2) Correlation analysis revealed a significant negative association between leptin levels and the depressed factor scores on the Positive and Negative Syndrome Scale (PANSS). (3) Stepwise multiple regression analyses identified leptin as an influencing factor for depressed factor score on PANSS.Conclusion Leptin may serve as a predictor for the depressive symptoms of chronic schizophrenia. |
| format | Article |
| id | doaj-art-c5de85fc6f1146c59680615bd91f770b |
| institution | Kabale University |
| issn | 2517-729X |
| language | English |
| publishDate | 2018-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | General Psychiatry |
| spelling | doaj-art-c5de85fc6f1146c59680615bd91f770b2024-11-08T12:30:08ZengBMJ Publishing GroupGeneral Psychiatry2517-729X2018-12-0131310.1136/gpsych-2018-100018Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophreniaJinjie Xu0Yumei Jiao1Mengjuan Xing2Yezhe Lin3Yousong Su4Wenhua Ding5Cuizhen Zhu6Yanmin Peng7Dake Qi8Donghong Cui92 Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China1 Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China1 Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, ChinaDepartment of Psychiatry and Behavioral Medicine, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA1 Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China1 Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China1 Anhui Clinical Research Center for Mental Disorders, Affiliated Psychological Hospital of Anhui Medical University, Hefei, Anhui, China1 Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China1 Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China1 Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, ChinaBackground Depressive symptoms are often seen in schizophrenia. The overlap in presentation makes it difficult to distinguish depressive symptoms from the negative symptoms of schizophrenia. The adipokine leptin was found to be altered in both depression and schizophrenia. There are few studies focusing on the prediction of leptin in diagnosis and evaluation of depressive symptoms in schizophrenia.ObjectiveAims To assess the plasma leptin level in patients with schizophrenia and its relationships with depressive symptoms.Methods Cross-sectional studies were applied to (1) compare the levels of plasma leptin between schizophrenia (n=74) and healthy controls (n=50); and (2) investigate the relationship between plasma leptin levels and depressive subscores.Results (1) Plasma leptin levels were significantly higher in patients with schizophrenia than in healthy controls. (2) Correlation analysis revealed a significant negative association between leptin levels and the depressed factor scores on the Positive and Negative Syndrome Scale (PANSS). (3) Stepwise multiple regression analyses identified leptin as an influencing factor for depressed factor score on PANSS.Conclusion Leptin may serve as a predictor for the depressive symptoms of chronic schizophrenia.https://gpsych.bmj.com/content/31/3/e100018.full |
| spellingShingle | Jinjie Xu Yumei Jiao Mengjuan Xing Yezhe Lin Yousong Su Wenhua Ding Cuizhen Zhu Yanmin Peng Dake Qi Donghong Cui Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia General Psychiatry |
| title | Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia |
| title_full | Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia |
| title_fullStr | Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia |
| title_full_unstemmed | Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia |
| title_short | Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia |
| title_sort | increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia |
| url | https://gpsych.bmj.com/content/31/3/e100018.full |
| work_keys_str_mv | AT jinjiexu increasedplasmaleptinasanovelpredictorforpsychopathologicaldepressivesymptomsinchronicschizophrenia AT yumeijiao increasedplasmaleptinasanovelpredictorforpsychopathologicaldepressivesymptomsinchronicschizophrenia AT mengjuanxing increasedplasmaleptinasanovelpredictorforpsychopathologicaldepressivesymptomsinchronicschizophrenia AT yezhelin increasedplasmaleptinasanovelpredictorforpsychopathologicaldepressivesymptomsinchronicschizophrenia AT yousongsu increasedplasmaleptinasanovelpredictorforpsychopathologicaldepressivesymptomsinchronicschizophrenia AT wenhuading increasedplasmaleptinasanovelpredictorforpsychopathologicaldepressivesymptomsinchronicschizophrenia AT cuizhenzhu increasedplasmaleptinasanovelpredictorforpsychopathologicaldepressivesymptomsinchronicschizophrenia AT yanminpeng increasedplasmaleptinasanovelpredictorforpsychopathologicaldepressivesymptomsinchronicschizophrenia AT dakeqi increasedplasmaleptinasanovelpredictorforpsychopathologicaldepressivesymptomsinchronicschizophrenia AT donghongcui increasedplasmaleptinasanovelpredictorforpsychopathologicaldepressivesymptomsinchronicschizophrenia |