Targeting microglial NAAA-regulated PEA signaling counters inflammatory damage and symptom progression of post-stroke anxiety

Targeting microglial NAAA-regulated PEA signaling counters inflammatory damage and symptom progression of post-stroke anxiety

Abstract Post-stroke anxiety (PSA) manifests as anxiety symptoms after stroke, with unclear mechanisms and limited treatment strategies. Endocannabinoids, reported to mitigate fear, anxiety, and stress, undergo dynamic alterations after stroke linked to prognosis intricately. However, endocannabinoi...

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Bibliographic Details
Main Authors: Tianyue Yin, Shuaijie Sun, Li Peng, Mengmeng Yang, Mengyu Li, Xinlu Yang, Fengyun Yuan, Hongrui Zhu, Sheng Wang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cell Communication and Signaling
Subjects:
Microglia
Stroke
Post-stroke anxiety
N-palmitoylethanolamide
N-acylethanolamine acid amidase
Online Access:https://doi.org/10.1186/s12964-025-02202-2
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