TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA WITH HIGH WHITE CELL BLOOD COUNTS.
<p class="MsoNormal" style="text-align: justify; line-height: 150%; margin: 0cm 0cm 0pt;"><span style="line-height: 150%; font-family: ";Arial";,";sans-serif";; font-size: 10pt; mso-fareast-font-family: Arial; mso-bidi-font-size: 14.0...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2011-01-01
|
| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.mjhid.org/article/view/8840 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846095543415078912 |
|---|---|
| author | Lionel Ades Charicleia Kelaidi Pierre Fenaux |
| author_facet | Lionel Ades Charicleia Kelaidi Pierre Fenaux |
| author_sort | Lionel Ades |
| collection | DOAJ |
| description | <p class="MsoNormal" style="text-align: justify; line-height: 150%; margin: 0cm 0cm 0pt;"><span style="line-height: 150%; font-family: ";Arial";,";sans-serif";; font-size: 10pt; mso-fareast-font-family: Arial; mso-bidi-font-size: 14.0pt;" lang="FR">Acute promyelocytic leukemia (APL) with WBC above 10 G/L has long been considered, even in the all-trans retinoic acid (ATRA) era, to carry a relatively poor prognosis (compared to<span style="mso-spacerun: yes;"> </span>APL with WBC below 10 G/L), due to increased early mortality and relapse. However, early deaths can to a large extent be avoided if specific measures are rapidly instigated, including prompt referral to a specialized center, immediate onset of ATRA and chemotherapy, treatment of coagulopathy with adequate platelet transfusional support, and prevention and management of differentiation syndrome. Strategies to reduce relapse rate include chemotherapy reinforcement with cytarabine and/or arsenic trioxide during consolidation, prolonged maintenance treatment, especially with ATRA and low dose chemotherapy, and possibly, although this is debated, intrathecal prophylaxis to prevent central nervous system relapse. By applying those measures, outcomes of patients with high risk APL have considerably improved, and have become in many studies almost similar to those of standard risk APL patients.</span></p><p class="MsoNormal" style="text-align: justify; line-height: 150%; margin: 0cm 0cm 0pt;"><span style="line-height: 150%; font-family: ";Arial";,";sans-serif";; font-size: 10pt; mso-fareast-font-family: Arial; mso-bidi-font-size: 14.0pt;" lang="FR"> </span></p> |
| format | Article |
| id | doaj-art-c5cfae22b84d4eecb9b416db1d89d0c4 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-c5cfae22b84d4eecb9b416db1d89d0c42025-01-02T10:23:34ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062011-01-0131e2011038e2011038TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA WITH HIGH WHITE CELL BLOOD COUNTS.Lionel AdesCharicleia KelaidiPierre Fenaux<p class="MsoNormal" style="text-align: justify; line-height: 150%; margin: 0cm 0cm 0pt;"><span style="line-height: 150%; font-family: ";Arial";,";sans-serif";; font-size: 10pt; mso-fareast-font-family: Arial; mso-bidi-font-size: 14.0pt;" lang="FR">Acute promyelocytic leukemia (APL) with WBC above 10 G/L has long been considered, even in the all-trans retinoic acid (ATRA) era, to carry a relatively poor prognosis (compared to<span style="mso-spacerun: yes;"> </span>APL with WBC below 10 G/L), due to increased early mortality and relapse. However, early deaths can to a large extent be avoided if specific measures are rapidly instigated, including prompt referral to a specialized center, immediate onset of ATRA and chemotherapy, treatment of coagulopathy with adequate platelet transfusional support, and prevention and management of differentiation syndrome. Strategies to reduce relapse rate include chemotherapy reinforcement with cytarabine and/or arsenic trioxide during consolidation, prolonged maintenance treatment, especially with ATRA and low dose chemotherapy, and possibly, although this is debated, intrathecal prophylaxis to prevent central nervous system relapse. By applying those measures, outcomes of patients with high risk APL have considerably improved, and have become in many studies almost similar to those of standard risk APL patients.</span></p><p class="MsoNormal" style="text-align: justify; line-height: 150%; margin: 0cm 0cm 0pt;"><span style="line-height: 150%; font-family: ";Arial";,";sans-serif";; font-size: 10pt; mso-fareast-font-family: Arial; mso-bidi-font-size: 14.0pt;" lang="FR"> </span></p>http://www.mjhid.org/article/view/8840Leukemia, Promyelocytic Leukemia, Hyperleucocytosysis |
| spellingShingle | Lionel Ades Charicleia Kelaidi Pierre Fenaux TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA WITH HIGH WHITE CELL BLOOD COUNTS. Mediterranean Journal of Hematology and Infectious Diseases Leukemia, Promyelocytic Leukemia, Hyperleucocytosysis |
| title | TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA WITH HIGH WHITE CELL BLOOD COUNTS. |
| title_full | TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA WITH HIGH WHITE CELL BLOOD COUNTS. |
| title_fullStr | TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA WITH HIGH WHITE CELL BLOOD COUNTS. |
| title_full_unstemmed | TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA WITH HIGH WHITE CELL BLOOD COUNTS. |
| title_short | TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA WITH HIGH WHITE CELL BLOOD COUNTS. |
| title_sort | treatment of acute promyelocytic leukemia with high white cell blood counts |
| topic | Leukemia, Promyelocytic Leukemia, Hyperleucocytosysis |
| url | http://www.mjhid.org/article/view/8840 |
| work_keys_str_mv | AT lionelades treatmentofacutepromyelocyticleukemiawithhighwhitecellbloodcounts AT charicleiakelaidi treatmentofacutepromyelocyticleukemiawithhighwhitecellbloodcounts AT pierrefenaux treatmentofacutepromyelocyticleukemiawithhighwhitecellbloodcounts |