Comparison of Three-Bag Method Acetylcysteine Versus Two-Bag Method Acetylcysteine for the Treatment of Acetaminophen Toxicity: An Updated Systematic Review and Meta-Analysis
Background: Acetaminophen is generally considered safe when used according to the recommended guidelines. Consumption in excessive doses can lead to severe liver damage and, in critical cases, may even result in death. To reduce the effects of acetaminophen overdose, N-acetylcysteine (NAC) has been...
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MDPI AG
2024-12-01
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| author | Mohammed Alrashed Abdulrahman Alyousef Hisham A. Badreldin Khalid Bin Saleh Shmeylan Al Harbi Abdulkareem M. Albekairy Abrar Alghamdi Amal Al-Nahdi Dhay Alonazi Mohammed Alnuhait Abdullah Alshammari Tariq Alqahtani |
| author_facet | Mohammed Alrashed Abdulrahman Alyousef Hisham A. Badreldin Khalid Bin Saleh Shmeylan Al Harbi Abdulkareem M. Albekairy Abrar Alghamdi Amal Al-Nahdi Dhay Alonazi Mohammed Alnuhait Abdullah Alshammari Tariq Alqahtani |
| author_sort | Mohammed Alrashed |
| collection | DOAJ |
| description | Background: Acetaminophen is generally considered safe when used according to the recommended guidelines. Consumption in excessive doses can lead to severe liver damage and, in critical cases, may even result in death. To reduce the effects of acetaminophen overdose, N-acetylcysteine (NAC) has been established as the preferred intervention to prevent liver damage. Objectives: The purpose of this updated systematic review and meta-analysis is to evaluate the potential benefits of a two-bag N-acetylcysteine (NAC) dosing regimen compared to the traditional three-bag protocol in the treatment of acetaminophen-induced liver toxicity. Methods: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The research team utilized the PubMed and Cochrane databases to perform a thorough and comprehensive search of the relevant literature from the inception of these databases up until January 2024. Results: Nine studies were included. The overall use of two-bag NAC was associated with lower anaphylactic reactions and gastrointestinal symptoms compared to the three-bag method. The rate of liver toxicity resolution was the same between the two treatment groups. Conclusions: The two-bag NAC regimen can be considered a safe and effective method for managing acetaminophen toxicity. |
| format | Article |
| id | doaj-art-c5c84b7f437d44c7b9170c8bd2530909 |
| institution | Kabale University |
| issn | 2079-9721 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj-art-c5c84b7f437d44c7b9170c8bd25309092024-12-27T14:21:22ZengMDPI AGDiseases2079-97212024-12-01121233210.3390/diseases12120332Comparison of Three-Bag Method Acetylcysteine Versus Two-Bag Method Acetylcysteine for the Treatment of Acetaminophen Toxicity: An Updated Systematic Review and Meta-AnalysisMohammed Alrashed0Abdulrahman Alyousef1Hisham A. Badreldin2Khalid Bin Saleh3Shmeylan Al Harbi4Abdulkareem M. Albekairy5Abrar Alghamdi6Amal Al-Nahdi7Dhay Alonazi8Mohammed Alnuhait9Abdullah Alshammari10Tariq Alqahtani11College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh 14611, Saudi ArabiaCollege of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh 14611, Saudi ArabiaCollege of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh 14611, Saudi ArabiaCollege of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh 14611, Saudi ArabiaCollege of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh 14611, Saudi ArabiaCollege of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh 14611, Saudi ArabiaCollege of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh 14611, Saudi ArabiaCollege of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh 14611, Saudi ArabiaCollege of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh 14611, Saudi ArabiaDepartment of Pharmacy Practice, College of Pharmacy, Umm Al-Qura University, Makkah 24382, Saudi ArabiaDepartment of Pharmacy Practice, College of Pharmacy, Umm Al-Qura University, Makkah 24382, Saudi ArabiaCollege of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh 14611, Saudi ArabiaBackground: Acetaminophen is generally considered safe when used according to the recommended guidelines. Consumption in excessive doses can lead to severe liver damage and, in critical cases, may even result in death. To reduce the effects of acetaminophen overdose, N-acetylcysteine (NAC) has been established as the preferred intervention to prevent liver damage. Objectives: The purpose of this updated systematic review and meta-analysis is to evaluate the potential benefits of a two-bag N-acetylcysteine (NAC) dosing regimen compared to the traditional three-bag protocol in the treatment of acetaminophen-induced liver toxicity. Methods: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The research team utilized the PubMed and Cochrane databases to perform a thorough and comprehensive search of the relevant literature from the inception of these databases up until January 2024. Results: Nine studies were included. The overall use of two-bag NAC was associated with lower anaphylactic reactions and gastrointestinal symptoms compared to the three-bag method. The rate of liver toxicity resolution was the same between the two treatment groups. Conclusions: The two-bag NAC regimen can be considered a safe and effective method for managing acetaminophen toxicity.https://www.mdpi.com/2079-9721/12/12/332toxicityacetaminophenantidote |
| spellingShingle | Mohammed Alrashed Abdulrahman Alyousef Hisham A. Badreldin Khalid Bin Saleh Shmeylan Al Harbi Abdulkareem M. Albekairy Abrar Alghamdi Amal Al-Nahdi Dhay Alonazi Mohammed Alnuhait Abdullah Alshammari Tariq Alqahtani Comparison of Three-Bag Method Acetylcysteine Versus Two-Bag Method Acetylcysteine for the Treatment of Acetaminophen Toxicity: An Updated Systematic Review and Meta-Analysis Diseases toxicity acetaminophen antidote |
| title | Comparison of Three-Bag Method Acetylcysteine Versus Two-Bag Method Acetylcysteine for the Treatment of Acetaminophen Toxicity: An Updated Systematic Review and Meta-Analysis |
| title_full | Comparison of Three-Bag Method Acetylcysteine Versus Two-Bag Method Acetylcysteine for the Treatment of Acetaminophen Toxicity: An Updated Systematic Review and Meta-Analysis |
| title_fullStr | Comparison of Three-Bag Method Acetylcysteine Versus Two-Bag Method Acetylcysteine for the Treatment of Acetaminophen Toxicity: An Updated Systematic Review and Meta-Analysis |
| title_full_unstemmed | Comparison of Three-Bag Method Acetylcysteine Versus Two-Bag Method Acetylcysteine for the Treatment of Acetaminophen Toxicity: An Updated Systematic Review and Meta-Analysis |
| title_short | Comparison of Three-Bag Method Acetylcysteine Versus Two-Bag Method Acetylcysteine for the Treatment of Acetaminophen Toxicity: An Updated Systematic Review and Meta-Analysis |
| title_sort | comparison of three bag method acetylcysteine versus two bag method acetylcysteine for the treatment of acetaminophen toxicity an updated systematic review and meta analysis |
| topic | toxicity acetaminophen antidote |
| url | https://www.mdpi.com/2079-9721/12/12/332 |
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