Exploring the relation between patent ductus arteriosus and bronchopulmonary dysplasia: Insights from national inpatient sample
Background: Bronchopulmonary dysplasia (BPD) poses a challenge in neonatal care. Previous literature recommended a hypothetical role for patent ductus arteriosus (PDA) in the development of BPD. This study explores the possible link between PDA and BPD, aiming to illuminate demographic and clinical...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-11-01
|
| Series: | Annals of Pediatric Cardiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/apc.apc_118_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846139798845128704 |
|---|---|
| author | Kirellos Said Abbas Abdulrahman Al-Matary Rawan Elabd Michele Fouad Nouran Badreldin Muhannad Sharara Moustafa Elsebey Monica Dobs Adnan I. Qureshi Abdul Rahman Adi Afrah Ghawi Ghadeer Ghazi Alahmadi Huda Yahya Alyahyawi Ahlam Mazi Reem Abdullah Alyoubi |
| author_facet | Kirellos Said Abbas Abdulrahman Al-Matary Rawan Elabd Michele Fouad Nouran Badreldin Muhannad Sharara Moustafa Elsebey Monica Dobs Adnan I. Qureshi Abdul Rahman Adi Afrah Ghawi Ghadeer Ghazi Alahmadi Huda Yahya Alyahyawi Ahlam Mazi Reem Abdullah Alyoubi |
| author_sort | Kirellos Said Abbas |
| collection | DOAJ |
| description | Background:
Bronchopulmonary dysplasia (BPD) poses a challenge in neonatal care. Previous literature recommended a hypothetical role for patent ductus arteriosus (PDA) in the development of BPD. This study explores the possible link between PDA and BPD, aiming to illuminate demographic and clinical factors influencing BPD development within the context of PDA.
Methods:
This retrospective cohort analysis employed data from the National Inpatient Sample (NIS) spanning from 2016 to 2020. The study focused on patients diagnosed with PDA and BPD, identified through International Classification of Diseases 10th Revision codes Q250 and P271, respectively. Utilizing STATA ×15, descriptive and inferential statistics, encompassing univariate and multivariate regression analyses, were conducted to examine the association between PDA and BPD.
Results:
A total of 9737 patients were included: 5133 without PDA and 4604 with PDA. The mortality rate was significantly higher among patients with PDA (3.80%) compared to those without PDA (2.53%) (P < 0.0001). Univariate and multivariate regression analyses identified a significant association between PDA and BPD, with odds ratios of 14.62 and 2.43, respectively (both P < 0.0001). BPD patients with PDA also exhibited a significantly higher prevalence of extremely preterm birth (76.24% vs. 58.31%, P < 0.0001) and extremely low birth weight (65.57% vs. 42.70%, P < 0.0001) compared to BPD patients without PDA. In addition, significant associations were observed between BPD and factors such as preterm birth category, neonatal sepsis, race, hospital status, and region (all P < 0.0001).
Conclusions:
This research confirms the connection between PDA and BPD, stressing the importance of continued investigation and prospective studies. The findings highlight the need to consider several factors in understanding the etiology of the disease, which could lead to more targeted interventions and improved patient care. |
| format | Article |
| id | doaj-art-c5c65e29256e43c49c5e41a61f298f5a |
| institution | Kabale University |
| issn | 0974-2069 0974-5149 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Pediatric Cardiology |
| spelling | doaj-art-c5c65e29256e43c49c5e41a61f298f5a2024-12-06T05:54:01ZengWolters Kluwer Medknow PublicationsAnnals of Pediatric Cardiology0974-20690974-51492024-11-0117425025610.4103/apc.apc_118_24Exploring the relation between patent ductus arteriosus and bronchopulmonary dysplasia: Insights from national inpatient sampleKirellos Said AbbasAbdulrahman Al-MataryRawan ElabdMichele FouadNouran BadreldinMuhannad ShararaMoustafa ElsebeyMonica DobsAdnan I. QureshiAbdul Rahman AdiAfrah GhawiGhadeer Ghazi AlahmadiHuda Yahya AlyahyawiAhlam MaziReem Abdullah AlyoubiBackground: Bronchopulmonary dysplasia (BPD) poses a challenge in neonatal care. Previous literature recommended a hypothetical role for patent ductus arteriosus (PDA) in the development of BPD. This study explores the possible link between PDA and BPD, aiming to illuminate demographic and clinical factors influencing BPD development within the context of PDA. Methods: This retrospective cohort analysis employed data from the National Inpatient Sample (NIS) spanning from 2016 to 2020. The study focused on patients diagnosed with PDA and BPD, identified through International Classification of Diseases 10th Revision codes Q250 and P271, respectively. Utilizing STATA ×15, descriptive and inferential statistics, encompassing univariate and multivariate regression analyses, were conducted to examine the association between PDA and BPD. Results: A total of 9737 patients were included: 5133 without PDA and 4604 with PDA. The mortality rate was significantly higher among patients with PDA (3.80%) compared to those without PDA (2.53%) (P < 0.0001). Univariate and multivariate regression analyses identified a significant association between PDA and BPD, with odds ratios of 14.62 and 2.43, respectively (both P < 0.0001). BPD patients with PDA also exhibited a significantly higher prevalence of extremely preterm birth (76.24% vs. 58.31%, P < 0.0001) and extremely low birth weight (65.57% vs. 42.70%, P < 0.0001) compared to BPD patients without PDA. In addition, significant associations were observed between BPD and factors such as preterm birth category, neonatal sepsis, race, hospital status, and region (all P < 0.0001). Conclusions: This research confirms the connection between PDA and BPD, stressing the importance of continued investigation and prospective studies. The findings highlight the need to consider several factors in understanding the etiology of the disease, which could lead to more targeted interventions and improved patient care.https://journals.lww.com/10.4103/apc.apc_118_24national inpatient sample datasetretrospective cohort analysisrisk factors and prevalence of bronchopulmonary dysplasia |
| spellingShingle | Kirellos Said Abbas Abdulrahman Al-Matary Rawan Elabd Michele Fouad Nouran Badreldin Muhannad Sharara Moustafa Elsebey Monica Dobs Adnan I. Qureshi Abdul Rahman Adi Afrah Ghawi Ghadeer Ghazi Alahmadi Huda Yahya Alyahyawi Ahlam Mazi Reem Abdullah Alyoubi Exploring the relation between patent ductus arteriosus and bronchopulmonary dysplasia: Insights from national inpatient sample Annals of Pediatric Cardiology national inpatient sample dataset retrospective cohort analysis risk factors and prevalence of bronchopulmonary dysplasia |
| title | Exploring the relation between patent ductus arteriosus and bronchopulmonary dysplasia: Insights from national inpatient sample |
| title_full | Exploring the relation between patent ductus arteriosus and bronchopulmonary dysplasia: Insights from national inpatient sample |
| title_fullStr | Exploring the relation between patent ductus arteriosus and bronchopulmonary dysplasia: Insights from national inpatient sample |
| title_full_unstemmed | Exploring the relation between patent ductus arteriosus and bronchopulmonary dysplasia: Insights from national inpatient sample |
| title_short | Exploring the relation between patent ductus arteriosus and bronchopulmonary dysplasia: Insights from national inpatient sample |
| title_sort | exploring the relation between patent ductus arteriosus and bronchopulmonary dysplasia insights from national inpatient sample |
| topic | national inpatient sample dataset retrospective cohort analysis risk factors and prevalence of bronchopulmonary dysplasia |
| url | https://journals.lww.com/10.4103/apc.apc_118_24 |
| work_keys_str_mv | AT kirellossaidabbas exploringtherelationbetweenpatentductusarteriosusandbronchopulmonarydysplasiainsightsfromnationalinpatientsample AT abdulrahmanalmatary exploringtherelationbetweenpatentductusarteriosusandbronchopulmonarydysplasiainsightsfromnationalinpatientsample AT rawanelabd exploringtherelationbetweenpatentductusarteriosusandbronchopulmonarydysplasiainsightsfromnationalinpatientsample AT michelefouad exploringtherelationbetweenpatentductusarteriosusandbronchopulmonarydysplasiainsightsfromnationalinpatientsample AT nouranbadreldin exploringtherelationbetweenpatentductusarteriosusandbronchopulmonarydysplasiainsightsfromnationalinpatientsample AT muhannadsharara exploringtherelationbetweenpatentductusarteriosusandbronchopulmonarydysplasiainsightsfromnationalinpatientsample AT moustafaelsebey exploringtherelationbetweenpatentductusarteriosusandbronchopulmonarydysplasiainsightsfromnationalinpatientsample AT monicadobs exploringtherelationbetweenpatentductusarteriosusandbronchopulmonarydysplasiainsightsfromnationalinpatientsample AT adnaniqureshi exploringtherelationbetweenpatentductusarteriosusandbronchopulmonarydysplasiainsightsfromnationalinpatientsample AT abdulrahmanadi exploringtherelationbetweenpatentductusarteriosusandbronchopulmonarydysplasiainsightsfromnationalinpatientsample AT afrahghawi exploringtherelationbetweenpatentductusarteriosusandbronchopulmonarydysplasiainsightsfromnationalinpatientsample AT ghadeerghazialahmadi exploringtherelationbetweenpatentductusarteriosusandbronchopulmonarydysplasiainsightsfromnationalinpatientsample AT hudayahyaalyahyawi exploringtherelationbetweenpatentductusarteriosusandbronchopulmonarydysplasiainsightsfromnationalinpatientsample AT ahlammazi exploringtherelationbetweenpatentductusarteriosusandbronchopulmonarydysplasiainsightsfromnationalinpatientsample AT reemabdullahalyoubi exploringtherelationbetweenpatentductusarteriosusandbronchopulmonarydysplasiainsightsfromnationalinpatientsample |