Sciellin inhibits senescence and promotes pancreatic cancer progress by activating the notch signaling pathway

Sciellin inhibits senescence and promotes pancreatic cancer progress by activating the notch signaling pathway

Abstract Pancreatic cancer (PC) incidence is increasing annually globally, and the five-year survival rate of patients with PC is approximately 10%. Cellular senescence is a regulatory mechanism against cancer that prevents tumor development by inhibiting the proliferation of damaged or abnormal cel...

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Bibliographic Details
Main Authors: Changhao Wu, Dan Luo, Binbin Shi, Shiyu Chen, Chengyi Sun, Zhiwei He, Chao Yu
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Pancreatic cancer
Senescence
SCEL
Jagged-1
Notch signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-88265-0
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