Sciellin inhibits senescence and promotes pancreatic cancer progress by activating the notch signaling pathway

Abstract Pancreatic cancer (PC) incidence is increasing annually globally, and the five-year survival rate of patients with PC is approximately 10%. Cellular senescence is a regulatory mechanism against cancer that prevents tumor development by inhibiting the proliferation of damaged or abnormal cel...

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Bibliographic Details
Main Authors: Changhao Wu, Dan Luo, Binbin Shi, Shiyu Chen, Chengyi Sun, Zhiwei He, Chao Yu
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-025-88265-0
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