Efficacy and safety of brivudine for the treatment of herpes zoster: a systematic review and meta-analysis
Background and objective Brivudine has been used in herpes zoster (HZ) treatment for years, but the safety and efficacy of brivudine are inconclusive. Here we perform a meta-analysis to assess the efficacy, safety, incidence of postherpetic neuralgia of brivudine.Methods Data of randomized controlle...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2024.2355256 |
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| author | Jiaxing Chen Dongyun Lei Peng Cao Junchen He Litao Zhang |
| author_facet | Jiaxing Chen Dongyun Lei Peng Cao Junchen He Litao Zhang |
| author_sort | Jiaxing Chen |
| collection | DOAJ |
| description | Background and objective Brivudine has been used in herpes zoster (HZ) treatment for years, but the safety and efficacy of brivudine are inconclusive. Here we perform a meta-analysis to assess the efficacy, safety, incidence of postherpetic neuralgia of brivudine.Methods Data of randomized controlled Trials (RCTS) were obtained from the databases of both English (PubMed, Embase, and Cochrane Library) and Chinese (China National Knowledge Infrastructure, China Science Journal Database, and WanFang Database) literatures from inception to 12 September 2022. Meta-analyses of efficacy and safety of Brivudine for the treatment of herpes zoster for RCTS were conducted.Results The analyses included seven RCTS (2095 patients in experimental group and 2076 patients in control group) in the treatment of HZ with brivudine. It suggested that the brivudine group was superior to the control group in terms of efficacy (p = .0002) and incidence of postherpetic neuralgia (p = .04). But the incidence of adverse reactions has no significant difference between the brivudine and the control groups (p = .22). In addition, subgroup analysis of adverse events also showed that brivudine was about the same safety as other modalities in the treatment of HZ (p > .05).Conclusions Brivudine is effective for HZ. However, the evidence on the safety of brivudine is insufficient. |
| format | Article |
| id | doaj-art-c5b3cc7d338d44f4a0d1db02850413c3 |
| institution | Kabale University |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-c5b3cc7d338d44f4a0d1db02850413c32024-12-16T22:53:47ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532024-12-0135110.1080/09546634.2024.2355256Efficacy and safety of brivudine for the treatment of herpes zoster: a systematic review and meta-analysisJiaxing Chen0Dongyun Lei1Peng Cao2Junchen He3Litao Zhang4Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, ChinaDepartment of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, ChinaDepartment of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, ChinaDepartment of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, ChinaBackground and objective Brivudine has been used in herpes zoster (HZ) treatment for years, but the safety and efficacy of brivudine are inconclusive. Here we perform a meta-analysis to assess the efficacy, safety, incidence of postherpetic neuralgia of brivudine.Methods Data of randomized controlled Trials (RCTS) were obtained from the databases of both English (PubMed, Embase, and Cochrane Library) and Chinese (China National Knowledge Infrastructure, China Science Journal Database, and WanFang Database) literatures from inception to 12 September 2022. Meta-analyses of efficacy and safety of Brivudine for the treatment of herpes zoster for RCTS were conducted.Results The analyses included seven RCTS (2095 patients in experimental group and 2076 patients in control group) in the treatment of HZ with brivudine. It suggested that the brivudine group was superior to the control group in terms of efficacy (p = .0002) and incidence of postherpetic neuralgia (p = .04). But the incidence of adverse reactions has no significant difference between the brivudine and the control groups (p = .22). In addition, subgroup analysis of adverse events also showed that brivudine was about the same safety as other modalities in the treatment of HZ (p > .05).Conclusions Brivudine is effective for HZ. However, the evidence on the safety of brivudine is insufficient.https://www.tandfonline.com/doi/10.1080/09546634.2024.2355256Brivudineherpes zosteracyclovirvalaciclovirpostherpetic neuralgiameta-analysis |
| spellingShingle | Jiaxing Chen Dongyun Lei Peng Cao Junchen He Litao Zhang Efficacy and safety of brivudine for the treatment of herpes zoster: a systematic review and meta-analysis Journal of Dermatological Treatment Brivudine herpes zoster acyclovir valaciclovir postherpetic neuralgia meta-analysis |
| title | Efficacy and safety of brivudine for the treatment of herpes zoster: a systematic review and meta-analysis |
| title_full | Efficacy and safety of brivudine for the treatment of herpes zoster: a systematic review and meta-analysis |
| title_fullStr | Efficacy and safety of brivudine for the treatment of herpes zoster: a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and safety of brivudine for the treatment of herpes zoster: a systematic review and meta-analysis |
| title_short | Efficacy and safety of brivudine for the treatment of herpes zoster: a systematic review and meta-analysis |
| title_sort | efficacy and safety of brivudine for the treatment of herpes zoster a systematic review and meta analysis |
| topic | Brivudine herpes zoster acyclovir valaciclovir postherpetic neuralgia meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2024.2355256 |
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