α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation

α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation

Mushroom poisoning, predominantly caused by α-amanitin, is a critical food safety concern in worldwide, with severe cases leading to hepatotoxicity and fatalities. This study delves into the hepatotoxic effects of α-amanitin, focusing on the NLRP3 inflammasome and PPAR-γ's regulatory role in in...

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Bibliographic Details
Main Authors: Haowei Wang, Huijie Zhang, Lin Miao, Chan Wang, Hanxin Teng, Xiaodong Li, Xiaoxing Zhang, Genmeng Yang, Shangwen Wang, Xiaofeng Zeng
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
α-Amanitin
Hepatotoxicity
NLRP3 inflammasome
PPAR-γ
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325000855
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