Tetracyclines enhance antitumor T-cell immunity via the Zap70 signaling pathway

Tetracyclines enhance antitumor T-cell immunity via the Zap70 signaling pathway

Background Cancer immunotherapy including immune checkpoint inhibitors is only effective for a limited population of patients with cancer. Therefore, the development of novel cancer immunotherapy is anticipated. In preliminary studies, we demonstrated that tetracyclines enhanced T-cell responses. Th...

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Main Authors: Atsushi Kumanogoh, Hisashi Wada, Yoshito Takeda, Mari Tone, Yasushi Shintani, Kota Iwahori, Michinari Hirata, Azumi Ueyama, Akiyoshi Tani, Jun-Ichi Haruta
Format: Article
Language:English
Published: BMJ Publishing Group 2024-04-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/4/e008334.full
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