Receptor Binding Domain-Specific B Cell Memory Responses Among Individuals Vaccinated Against SARS-CoV-2
<b>Background</b>: The COVID-19 pandemic prompted unprecedented vaccine development efforts against SARS-CoV-2. India, which was one of the countries most impacted by COVID-19, developed its indigenous vaccine in addition to utilizing the ones developed by other countries. While antibody...
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2024-12-01
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| author | Atharv Athavale Anmol Gaur Nafees Ahmed Adarsh Subramaniam Jyotsna Dandotiya Sneha Raj Santosh Kumar Upadhyay Sweety Samal Anil Kumar Pandey Ramesh Chandra Rai Amit Awasthi |
| author_facet | Atharv Athavale Anmol Gaur Nafees Ahmed Adarsh Subramaniam Jyotsna Dandotiya Sneha Raj Santosh Kumar Upadhyay Sweety Samal Anil Kumar Pandey Ramesh Chandra Rai Amit Awasthi |
| author_sort | Atharv Athavale |
| collection | DOAJ |
| description | <b>Background</b>: The COVID-19 pandemic prompted unprecedented vaccine development efforts against SARS-CoV-2. India, which was one of the countries most impacted by COVID-19, developed its indigenous vaccine in addition to utilizing the ones developed by other countries. While antibody levels and neutralizing antibody titres are considered initial correlates of immune protection, long-term protection from the pathogen relies on memory B and T cells and their recall responses. In this regard, global research has primarily focused on mRNA-based vaccines. The studies on immune memory response, particularly B cell memory response induced by the vaccines given to Indians, remain relatively obscure. <b>Methods</b>: We assessed Receptor Binding Domain-specific memory B cells in the peripheral circulation and their ability to secrete antigen-specific antibodies among Indians vaccinated with Covaxin (BBV152), Covishield (AZD1222), Corbevax (BECOV2D), and Sputnik Light, as well as unvaccinated individuals. <b>Results</b>: Corbevax and Sputnik Light conferred better antibody-secreting cell (ASC) responses over time compared to other groups. <b>Conclusions</b>: These findings contribute to our understanding of vaccine-induced immune memory in the Indian population; providing insights that could inform future vaccine strategies. |
| format | Article |
| id | doaj-art-c564a9bad8b74c2a98e9c631c7291696 |
| institution | Kabale University |
| issn | 2076-393X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-c564a9bad8b74c2a98e9c631c72916962024-12-27T14:58:07ZengMDPI AGVaccines2076-393X2024-12-011212139610.3390/vaccines12121396Receptor Binding Domain-Specific B Cell Memory Responses Among Individuals Vaccinated Against SARS-CoV-2Atharv Athavale0Anmol Gaur1Nafees Ahmed2Adarsh Subramaniam3Jyotsna Dandotiya4Sneha Raj5Santosh Kumar Upadhyay6Sweety Samal7Anil Kumar Pandey8Ramesh Chandra Rai9Amit Awasthi10BRIC-Translational Health Science and Technology Institute, Faridabad 21001, IndiaBRIC-Translational Health Science and Technology Institute, Faridabad 21001, IndiaBRIC-Translational Health Science and Technology Institute, Faridabad 21001, IndiaBRIC-Translational Health Science and Technology Institute, Faridabad 21001, IndiaBRIC-Translational Health Science and Technology Institute, Faridabad 21001, IndiaBRIC-Translational Health Science and Technology Institute, Faridabad 21001, IndiaDepartment of Biotechnology, Kumaun University, Nainital 263001, IndiaBRIC-Translational Health Science and Technology Institute, Faridabad 21001, IndiaESIC Medical College and Hospital, Faridabad 121012, IndiaBRIC-Translational Health Science and Technology Institute, Faridabad 21001, IndiaBRIC-Translational Health Science and Technology Institute, Faridabad 21001, India<b>Background</b>: The COVID-19 pandemic prompted unprecedented vaccine development efforts against SARS-CoV-2. India, which was one of the countries most impacted by COVID-19, developed its indigenous vaccine in addition to utilizing the ones developed by other countries. While antibody levels and neutralizing antibody titres are considered initial correlates of immune protection, long-term protection from the pathogen relies on memory B and T cells and their recall responses. In this regard, global research has primarily focused on mRNA-based vaccines. The studies on immune memory response, particularly B cell memory response induced by the vaccines given to Indians, remain relatively obscure. <b>Methods</b>: We assessed Receptor Binding Domain-specific memory B cells in the peripheral circulation and their ability to secrete antigen-specific antibodies among Indians vaccinated with Covaxin (BBV152), Covishield (AZD1222), Corbevax (BECOV2D), and Sputnik Light, as well as unvaccinated individuals. <b>Results</b>: Corbevax and Sputnik Light conferred better antibody-secreting cell (ASC) responses over time compared to other groups. <b>Conclusions</b>: These findings contribute to our understanding of vaccine-induced immune memory in the Indian population; providing insights that could inform future vaccine strategies.https://www.mdpi.com/2076-393X/12/12/1396receptor-binding domain (RBD)memory B cell (MBC)antibody-secreting cell (ASC)severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)coronavirus disease 2019 (COVID-19) |
| spellingShingle | Atharv Athavale Anmol Gaur Nafees Ahmed Adarsh Subramaniam Jyotsna Dandotiya Sneha Raj Santosh Kumar Upadhyay Sweety Samal Anil Kumar Pandey Ramesh Chandra Rai Amit Awasthi Receptor Binding Domain-Specific B Cell Memory Responses Among Individuals Vaccinated Against SARS-CoV-2 Vaccines receptor-binding domain (RBD) memory B cell (MBC) antibody-secreting cell (ASC) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus disease 2019 (COVID-19) |
| title | Receptor Binding Domain-Specific B Cell Memory Responses Among Individuals Vaccinated Against SARS-CoV-2 |
| title_full | Receptor Binding Domain-Specific B Cell Memory Responses Among Individuals Vaccinated Against SARS-CoV-2 |
| title_fullStr | Receptor Binding Domain-Specific B Cell Memory Responses Among Individuals Vaccinated Against SARS-CoV-2 |
| title_full_unstemmed | Receptor Binding Domain-Specific B Cell Memory Responses Among Individuals Vaccinated Against SARS-CoV-2 |
| title_short | Receptor Binding Domain-Specific B Cell Memory Responses Among Individuals Vaccinated Against SARS-CoV-2 |
| title_sort | receptor binding domain specific b cell memory responses among individuals vaccinated against sars cov 2 |
| topic | receptor-binding domain (RBD) memory B cell (MBC) antibody-secreting cell (ASC) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus disease 2019 (COVID-19) |
| url | https://www.mdpi.com/2076-393X/12/12/1396 |
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