Validation of a liquid biopsy assay with increased sensitivity for clinical comprehensive genomic profiling

Validation of a liquid biopsy assay with increased sensitivity for clinical comprehensive genomic profiling

Recent advancements in precision oncology have affirmed the need for comprehensive genomic profiling (CGP) liquid biopsy assays with increased sensitivity, especially for detecting alterations in tumors which shed circulating tumor DNA (ctDNA) at low abundance. Such tests could address the limitatio...

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Bibliographic Details
Main Authors: Xavier S. Bower, Jan Wignall, Matthew G. Varga, Joyce Zhu, Michael O'Sullivan, Naomi E. Searle, Lenny K. Hong, Turgut Dogruluk, Zeqian Li, Tiffany E. Farmer, Emilio Rosas-Linhard, Jason Luong, Esther Lin, Marie Erica Simon, David S. Tsao, John R. ten Bosch, Gary Palmer, Ajeet Gajra, Chanh Huynh, Wen Zhou
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:The Journal of Liquid Biopsy
Subjects:
Liquid biopsy
Circulating tumor DNA
Comprehensive genomic profiling
Next generation sequencing
Precision oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2950195425000384
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