RAS pathway targeted therapy in patients with DICER1-associated sarcomas

RAS pathway targeted therapy in patients with DICER1-associated sarcomas

Abstract DICER1-associated sarcomas commonly exhibit cooperating mutations involving RAS signaling pathways, but the efficacy of therapies that target these mutations is unknown. Here we report two children with DICER1 tumor predisposition who presented with DICER1-associated sarcomas with cooperati...

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Main Authors: Lindy Zhang, Paige H. R. Mallinger, Serena Zhou, Stavriani C. Makri, John M. Gross, Calixto-Hope G. Lucas, Ying S. Zou, William Mize, Damon R. Olson, Senna R. Munnikhuysen, Jawhar Rawwas, Yoav Messinger, Kenneth S. Chen, Kris Ann P. Schultz, Christine A. Pratilas
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-01026-0
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