Characteristics of the hemagglutinins antibody responses in influenza A patients in Suez Governorate, Egypt
Background: Influenza is an acute respiratory illness caused by the Influenza virus. There are 3 types of Influenza virus A, B and C. Infection with the Influenza virus exhibits broad immune responses and protection from re-infection by the same type of virus. The protective humoral immune response...
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Zagazig University, Faculty of Medicine
2024-11-01
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| Series: | Microbes and Infectious Diseases |
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| Online Access: | https://mid.journals.ekb.eg/article_379967_00a24dd1afe8f969071e64706cfe0f90.pdf |
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| author | Rehab Tash Ahmed Mohamed Said Hamed Abbadi Mai Rashad |
| author_facet | Rehab Tash Ahmed Mohamed Said Hamed Abbadi Mai Rashad |
| author_sort | Rehab Tash |
| collection | DOAJ |
| description | Background: Influenza is an acute respiratory illness caused by the Influenza virus. There are 3 types of Influenza virus A, B and C. Infection with the Influenza virus exhibits broad immune responses and protection from re-infection by the same type of virus. The protective humoral immune response depends mainly on antibodies to the virus surface glycoprotein, hemagglutinin, and neuraminidase. Our study aims to reveal the characteristics of hemagglutinin reactive serum antibody responses in influenza patients in Suez Governorate. Methods: 160 cases were enrolled according to their clinical picture and symptoms onset not more than 10 days from the beginning of illness. Nasopharyngeal swabs were obtained from each case and tested for the influenza virus by rapid influenza antigen detection test. The proven influenza A samples were typed by real-time PCR. Each sample was mapped for their hemagglutinin (HA) antibodies rising titer by ELISA: group 1 HAs (H1, H5, H9) and group 2 HAs (H3 and H7). Results: 15 cases were diagnosed as influenza A with subtype H1N1. There was a rise in group 1HAs more than group 2 HAs when comparing the antibody titer of the 1st and 2nd serum samples. Group 1: H1 showed a 20-fold rise, H5 showed a 5-fold rise and H9 showed a 2-fold rise. Group 2: H3 and H9 showed a 5-fold rise. Conclusion: Following natural infection; Influenza A(H1N1) pdm09 virus induces a strong anti-HA immune response. |
| format | Article |
| id | doaj-art-c52765576b7f4c8d9c73c115dc2ed790 |
| institution | Kabale University |
| issn | 2682-4132 2682-4140 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj-art-c52765576b7f4c8d9c73c115dc2ed7902024-12-21T21:03:54ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402024-11-01541297130610.21608/mid.2024.311201.2147379967Characteristics of the hemagglutinins antibody responses in influenza A patients in Suez Governorate, EgyptRehab Tash0Ahmed Mohamed1Said Hamed Abbadi2Mai Rashad3Medical Microbiology and Immunology Department, Faculty pf Medicine, Zagazig University, EgyptMedical Microbiology and Immunology Department, Faculty pf Medicine, Zagazig University, EgyptMedical Microbiology and Immunology Department, Faculty pf Medicine, Suez University, EgyptMedical Microbiology and Immunology Department, Faculty pf Medicine, Suez University, EgyptBackground: Influenza is an acute respiratory illness caused by the Influenza virus. There are 3 types of Influenza virus A, B and C. Infection with the Influenza virus exhibits broad immune responses and protection from re-infection by the same type of virus. The protective humoral immune response depends mainly on antibodies to the virus surface glycoprotein, hemagglutinin, and neuraminidase. Our study aims to reveal the characteristics of hemagglutinin reactive serum antibody responses in influenza patients in Suez Governorate. Methods: 160 cases were enrolled according to their clinical picture and symptoms onset not more than 10 days from the beginning of illness. Nasopharyngeal swabs were obtained from each case and tested for the influenza virus by rapid influenza antigen detection test. The proven influenza A samples were typed by real-time PCR. Each sample was mapped for their hemagglutinin (HA) antibodies rising titer by ELISA: group 1 HAs (H1, H5, H9) and group 2 HAs (H3 and H7). Results: 15 cases were diagnosed as influenza A with subtype H1N1. There was a rise in group 1HAs more than group 2 HAs when comparing the antibody titer of the 1st and 2nd serum samples. Group 1: H1 showed a 20-fold rise, H5 showed a 5-fold rise and H9 showed a 2-fold rise. Group 2: H3 and H9 showed a 5-fold rise. Conclusion: Following natural infection; Influenza A(H1N1) pdm09 virus induces a strong anti-HA immune response.https://mid.journals.ekb.eg/article_379967_00a24dd1afe8f969071e64706cfe0f90.pdfkeywords: influenzaantigenhaemagglutininantibodiesreal time pcr |
| spellingShingle | Rehab Tash Ahmed Mohamed Said Hamed Abbadi Mai Rashad Characteristics of the hemagglutinins antibody responses in influenza A patients in Suez Governorate, Egypt Microbes and Infectious Diseases keywords: influenza antigen haemagglutinin antibodies real time pcr |
| title | Characteristics of the hemagglutinins antibody responses in influenza A patients in Suez Governorate, Egypt |
| title_full | Characteristics of the hemagglutinins antibody responses in influenza A patients in Suez Governorate, Egypt |
| title_fullStr | Characteristics of the hemagglutinins antibody responses in influenza A patients in Suez Governorate, Egypt |
| title_full_unstemmed | Characteristics of the hemagglutinins antibody responses in influenza A patients in Suez Governorate, Egypt |
| title_short | Characteristics of the hemagglutinins antibody responses in influenza A patients in Suez Governorate, Egypt |
| title_sort | characteristics of the hemagglutinins antibody responses in influenza a patients in suez governorate egypt |
| topic | keywords: influenza antigen haemagglutinin antibodies real time pcr |
| url | https://mid.journals.ekb.eg/article_379967_00a24dd1afe8f969071e64706cfe0f90.pdf |
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