Enzymatic Oxidative Stress Indicators and Oxidative Stress Index in Patients of Leprosy
Introduction: Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae. Oxidative stress caused by Reactive oxygen species (ROS) plays a crucial role in the pathogenesisis of leprosy. Objective: To measure the enzymatic oxidative stress indicators and oxidative stress index in pat...
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| Format: | Article |
| Language: | English |
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Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)
2018-03-01
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| Series: | Nepal Journal of Dermatology, Venereology & Leprology |
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| Online Access: | https://www.nepjol.info/index.php/NJDVL/article/view/19402 |
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| author | Ishita Raka Madhur Kant Rastogi pratik gahalaut jaspreet kaur nitin mishra |
| author_facet | Ishita Raka Madhur Kant Rastogi pratik gahalaut jaspreet kaur nitin mishra |
| author_sort | Ishita Raka |
| collection | DOAJ |
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Introduction: Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae. Oxidative stress caused by Reactive oxygen species (ROS) plays a crucial role in the pathogenesisis of leprosy.
Objective: To measure the enzymatic oxidative stress indicators and oxidative stress index in patients of leprosy and compare them with healthy age & sex matched controls.
Materials and Methods: In this prospective study 30 untreated leprosy patients were included in the study and matched with 60 healthy controls. Biochemistry estimation was done with blood samples and MDA (lipid peroxidation), Nitric oxide (NO), (SOD) Superoxide dismutase (antioxidant enzyme), total oxidant status (TOS), total antioxidant status(TAS) and oxidative stress index (OSI) were estimated.
Results: Highly significant rise (p<0.0001) in serum MDA, NO, TOS and OSI was seen in leprosy patients when compared with controls with highly significant decline in SOD and TAS.
Conclusion: The study confirms the oxidative stress in leprosy and suggests antioxidant therapy may be used as an adjuvant in the treatment of leprosy along with MDT.
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| format | Article |
| id | doaj-art-c5148aa25e964ada82b465a69d4b3cb0 |
| institution | Kabale University |
| issn | 2091-0231 2091-167X |
| language | English |
| publishDate | 2018-03-01 |
| publisher | Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON) |
| record_format | Article |
| series | Nepal Journal of Dermatology, Venereology & Leprology |
| spelling | doaj-art-c5148aa25e964ada82b465a69d4b3cb02025-08-23T10:04:42ZengSociety of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)Nepal Journal of Dermatology, Venereology & Leprology2091-02312091-167X2018-03-0116110.3126/njdvl.v16i1.19402Enzymatic Oxidative Stress Indicators and Oxidative Stress Index in Patients of LeprosyIshita Raka0Madhur Kant Rastogi1pratik gahalaut2jaspreet kaur3nitin mishra4Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, (U.P)Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, (U.P)Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, (U.P)Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, (U.P)Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, (U.P) Introduction: Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae. Oxidative stress caused by Reactive oxygen species (ROS) plays a crucial role in the pathogenesisis of leprosy. Objective: To measure the enzymatic oxidative stress indicators and oxidative stress index in patients of leprosy and compare them with healthy age & sex matched controls. Materials and Methods: In this prospective study 30 untreated leprosy patients were included in the study and matched with 60 healthy controls. Biochemistry estimation was done with blood samples and MDA (lipid peroxidation), Nitric oxide (NO), (SOD) Superoxide dismutase (antioxidant enzyme), total oxidant status (TOS), total antioxidant status(TAS) and oxidative stress index (OSI) were estimated. Results: Highly significant rise (p<0.0001) in serum MDA, NO, TOS and OSI was seen in leprosy patients when compared with controls with highly significant decline in SOD and TAS. Conclusion: The study confirms the oxidative stress in leprosy and suggests antioxidant therapy may be used as an adjuvant in the treatment of leprosy along with MDT. https://www.nepjol.info/index.php/NJDVL/article/view/19402Lipid peroxidationMycobacterium lepraeoxidantsreactive oxygen speciessuperoxide dismutase |
| spellingShingle | Ishita Raka Madhur Kant Rastogi pratik gahalaut jaspreet kaur nitin mishra Enzymatic Oxidative Stress Indicators and Oxidative Stress Index in Patients of Leprosy Nepal Journal of Dermatology, Venereology & Leprology Lipid peroxidation Mycobacterium leprae oxidants reactive oxygen species superoxide dismutase |
| title | Enzymatic Oxidative Stress Indicators and Oxidative Stress Index in Patients of Leprosy |
| title_full | Enzymatic Oxidative Stress Indicators and Oxidative Stress Index in Patients of Leprosy |
| title_fullStr | Enzymatic Oxidative Stress Indicators and Oxidative Stress Index in Patients of Leprosy |
| title_full_unstemmed | Enzymatic Oxidative Stress Indicators and Oxidative Stress Index in Patients of Leprosy |
| title_short | Enzymatic Oxidative Stress Indicators and Oxidative Stress Index in Patients of Leprosy |
| title_sort | enzymatic oxidative stress indicators and oxidative stress index in patients of leprosy |
| topic | Lipid peroxidation Mycobacterium leprae oxidants reactive oxygen species superoxide dismutase |
| url | https://www.nepjol.info/index.php/NJDVL/article/view/19402 |
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