Skin biomechanics: Breaking the dermal barriers with microneedles
ABSTRACT: Microneedles (μND) are promising devices that can be used to transport a wide variety of active compounds into the skin. To serve as an effective delivery system, μND must pierce the human stratum corneum (~10-20 μm), without breaking or buckling during penetration. In the current review,...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2022-03-01
|
| Series: | Nano TransMed |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2790676023000407 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846170039557816320 |
|---|---|
| author | Masood Ali Sarika Namjoshi Heather A.E. Benson Tushar Kumeria Yousuf Mohammed |
| author_facet | Masood Ali Sarika Namjoshi Heather A.E. Benson Tushar Kumeria Yousuf Mohammed |
| author_sort | Masood Ali |
| collection | DOAJ |
| description | ABSTRACT: Microneedles (μND) are promising devices that can be used to transport a wide variety of active compounds into the skin. To serve as an effective delivery system, μND must pierce the human stratum corneum (~10-20 μm), without breaking or buckling during penetration. In the current review, we discuss both the anatomical features and biomechanical properties of skin in order to understand the local environment and resistive forces relevant to μNDs insertion. Of particular importance are the factors that affect μND insertion, such as their geometry and material composition, as these can be manipulated in the design and development phase to optimise skin insertion. We review the research relevant to μND and how this interacts with skin properties. We have also reviewed the most commonly used skin drug diffusion modelling used to predict drug behaviour from μNDs, and discussed the current challenges faced by μNDs to enter clinical trials and provide positive clinical outcomes. |
| format | Article |
| id | doaj-art-c50e51980c604400ac2cbb81fa61efdf |
| institution | Kabale University |
| issn | 2790-6760 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Nano TransMed |
| spelling | doaj-art-c50e51980c604400ac2cbb81fa61efdf2024-11-12T05:22:06ZengKeAi Communications Co., Ltd.Nano TransMed2790-67602022-03-0111e9130002Skin biomechanics: Breaking the dermal barriers with microneedlesMasood Ali0Sarika Namjoshi1Heather A.E. Benson2Tushar Kumeria3Yousuf Mohammed4Therapeutics Research Group, The University of Queensland, Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, AustraliaTherapeutics Research Group, The University of Queensland, Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, AustraliaClinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia; Curtin Medical School, Curtin University, Perth, WA 6845, AustraliaSchool of Materials Science and Engineering, The University of New South Wales, Sydney, NSW 2052, Australia; Australian Centre for Nanomedicine, The University of New South Wales, Sydney, NSW 2052, AustraliaTherapeutics Research Group, The University of Queensland, Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, AustraliaABSTRACT: Microneedles (μND) are promising devices that can be used to transport a wide variety of active compounds into the skin. To serve as an effective delivery system, μND must pierce the human stratum corneum (~10-20 μm), without breaking or buckling during penetration. In the current review, we discuss both the anatomical features and biomechanical properties of skin in order to understand the local environment and resistive forces relevant to μNDs insertion. Of particular importance are the factors that affect μND insertion, such as their geometry and material composition, as these can be manipulated in the design and development phase to optimise skin insertion. We review the research relevant to μND and how this interacts with skin properties. We have also reviewed the most commonly used skin drug diffusion modelling used to predict drug behaviour from μNDs, and discussed the current challenges faced by μNDs to enter clinical trials and provide positive clinical outcomes.http://www.sciencedirect.com/science/article/pii/S2790676023000407skin thicknessskin viscoelasticityskin layersmicroneedlesskin penetrationstratum corneum |
| spellingShingle | Masood Ali Sarika Namjoshi Heather A.E. Benson Tushar Kumeria Yousuf Mohammed Skin biomechanics: Breaking the dermal barriers with microneedles Nano TransMed skin thickness skin viscoelasticity skin layers microneedles skin penetration stratum corneum |
| title | Skin biomechanics: Breaking the dermal barriers with microneedles |
| title_full | Skin biomechanics: Breaking the dermal barriers with microneedles |
| title_fullStr | Skin biomechanics: Breaking the dermal barriers with microneedles |
| title_full_unstemmed | Skin biomechanics: Breaking the dermal barriers with microneedles |
| title_short | Skin biomechanics: Breaking the dermal barriers with microneedles |
| title_sort | skin biomechanics breaking the dermal barriers with microneedles |
| topic | skin thickness skin viscoelasticity skin layers microneedles skin penetration stratum corneum |
| url | http://www.sciencedirect.com/science/article/pii/S2790676023000407 |
| work_keys_str_mv | AT masoodali skinbiomechanicsbreakingthedermalbarrierswithmicroneedles AT sarikanamjoshi skinbiomechanicsbreakingthedermalbarrierswithmicroneedles AT heatheraebenson skinbiomechanicsbreakingthedermalbarrierswithmicroneedles AT tusharkumeria skinbiomechanicsbreakingthedermalbarrierswithmicroneedles AT yousufmohammed skinbiomechanicsbreakingthedermalbarrierswithmicroneedles |