Interaction between mitochondrial quality control and metal-mediated cell death in sepsis and its clinical significance
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Its progression is closely associated with metal metabolism abnormalities and mitochondrial quality deterioration. Mitochondria serve as centers for energy metabolism and metal storage, and t...
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| Format: | Article |
| Language: | zho |
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Lanzhou University Press
2024-12-01
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| Series: | 生物医学转化 |
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| Online Access: | http://swyxzh.ijournals.cn/swyxzh/article/html/20240402 |
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| author | Zhou Qiyuan Li Jingyan Tian Yingping Yao Yongming |
| author_facet | Zhou Qiyuan Li Jingyan Tian Yingping Yao Yongming |
| author_sort | Zhou Qiyuan |
| collection | DOAJ |
| description | Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Its progression is closely associated with metal metabolism abnormalities and mitochondrial quality deterioration. Mitochondria serve as centers for energy metabolism and metal storage, and their quality control regulates metal-mediated cell death, influencing the progression of sepsis. This review discusses the mechanisms of mitochondrial quality control (MQC) and their relationship with metal-induced cell death. It explores the effects of metal metabolism and MQC changes on cell death under septic conditions. The interaction between these factors is further examined for its significance in the pathophysiological processes of sepsis and related complications. This paper provides new insights for its diagnosis and treatment. |
| format | Article |
| id | doaj-art-c5098d080b5a4ae98f274924e20a8073 |
| institution | Kabale University |
| issn | 2096-8965 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Lanzhou University Press |
| record_format | Article |
| series | 生物医学转化 |
| spelling | doaj-art-c5098d080b5a4ae98f274924e20a80732025-01-13T07:59:05ZzhoLanzhou University Press生物医学转化2096-89652024-12-01541321,3610.12287/j.issn.2096-8965.20240402Interaction between mitochondrial quality control and metal-mediated cell death in sepsis and its clinical significanceZhou Qiyuan0Li Jingyan1Tian Yingping2Yao Yongming3Emergency Department, The Second Hospital of Hebei Medical University, Shijiazhuang 050000 , Hebei, China ；Translational Medicine Research Center, Medical Innovation Research Divisionof the Chinese Peoples Liberation Army General Hospital, Beijing 100853 , ChinaEmergency Department, The Second Hospital of Hebei Medical University, Shijiazhuang 050000 , Hebei, China ；Translational Medicine Research Center, Medical Innovation Research Divisionof the Chinese Peoples Liberation Army General Hospital, Beijing 100853 , ChinaEmergency Department, The Second Hospital of Hebei Medical University, Shijiazhuang 050000 , Hebei, ChinaTranslational Medicine Research Center, Medical Innovation Research Divisionof the Chinese Peoples Liberation Army General Hospital, Beijing 100853 , ChinaSepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Its progression is closely associated with metal metabolism abnormalities and mitochondrial quality deterioration. Mitochondria serve as centers for energy metabolism and metal storage, and their quality control regulates metal-mediated cell death, influencing the progression of sepsis. This review discusses the mechanisms of mitochondrial quality control (MQC) and their relationship with metal-induced cell death. It explores the effects of metal metabolism and MQC changes on cell death under septic conditions. The interaction between these factors is further examined for its significance in the pathophysiological processes of sepsis and related complications. This paper provides new insights for its diagnosis and treatment.http://swyxzh.ijournals.cn/swyxzh/article/html/20240402sepsiscell deathmitochondrial quality controlimmunosuppression |
| spellingShingle | Zhou Qiyuan Li Jingyan Tian Yingping Yao Yongming Interaction between mitochondrial quality control and metal-mediated cell death in sepsis and its clinical significance 生物医学转化 sepsis cell death mitochondrial quality control immunosuppression |
| title | Interaction between mitochondrial quality control and metal-mediated cell death in sepsis and its clinical significance |
| title_full | Interaction between mitochondrial quality control and metal-mediated cell death in sepsis and its clinical significance |
| title_fullStr | Interaction between mitochondrial quality control and metal-mediated cell death in sepsis and its clinical significance |
| title_full_unstemmed | Interaction between mitochondrial quality control and metal-mediated cell death in sepsis and its clinical significance |
| title_short | Interaction between mitochondrial quality control and metal-mediated cell death in sepsis and its clinical significance |
| title_sort | interaction between mitochondrial quality control and metal mediated cell death in sepsis and its clinical significance |
| topic | sepsis cell death mitochondrial quality control immunosuppression |
| url | http://swyxzh.ijournals.cn/swyxzh/article/html/20240402 |
| work_keys_str_mv | AT zhouqiyuan interactionbetweenmitochondrialqualitycontrolandmetalmediatedcelldeathinsepsisanditsclinicalsignificance AT lijingyan interactionbetweenmitochondrialqualitycontrolandmetalmediatedcelldeathinsepsisanditsclinicalsignificance AT tianyingping interactionbetweenmitochondrialqualitycontrolandmetalmediatedcelldeathinsepsisanditsclinicalsignificance AT yaoyongming interactionbetweenmitochondrialqualitycontrolandmetalmediatedcelldeathinsepsisanditsclinicalsignificance |