Citric acid is more effective than sodium thiosulfate in chelating calcium in a dissolution model of calcinosis

Citric acid is more effective than sodium thiosulfate in chelating calcium in a dissolution model of calcinosis

Abstract Calcinosis cutis affects 20–40% of patients with systemic sclerosis. This study tests the hypothesis that calcium-chelating polycarboxylic acids can induce calcium dissolution without skin toxicity or irritancy. We compared citric acid (CA) and ethylenediaminetetraacetic acid (EDTA) to sodi...

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Bibliographic Details
Main Authors: Kyle A. Burgess, Richard E. P. Winpenny, Alberto Saiani, Aline F. Miller, Ariane L. Herrick, Rachel E. B. Watson
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-65761-3
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