Genetic variation in patent foramen ovale: a case-control genome-wide association study

Genetic variation in patent foramen ovale: a case-control genome-wide association study

BackgroundPatent foramen ovale (PFO) is a congenital defect between the atria, resulting in abnormal hemodynamics. We conducted a genome-wide association study (GWAS) to identify common genetic variants associated with PFO.MethodsWe performed a whole genome sequencing in a discovery cohort of 3,227...

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Bibliographic Details
Main Authors: Bosi Dong, Yajiao Li, Fandi Ai, Jia Geng, Ting Tang, Wan Peng, Yusha Tang, Hui Wang, Zixuan Tian, Fengxiao Bu, Lei Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Genetics
Subjects:
patent foramen ovale
genome-wide association study
heart development
common variants
single-cell sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2024.1523304/full
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