Maternal iron deficiency assessed by serum ferritin and birth outcomes in mainland China
Abstract Iron deficiency is prevalent among pregnant women because of the increased maternal iron requirements. Uncorrected maternal iron deficiency can lead to adverse neurodevelopmental outcomes in neonates. Therefore, the aim of this study was to assess serum ferritin concentration and prevalence...
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Nature Portfolio
2025-01-01
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| author | Hang Zhou Yiming Lu Jianying Luo Binyu Pan Qihua Zhao Min Chen Zheng Feei Ma |
| author_facet | Hang Zhou Yiming Lu Jianying Luo Binyu Pan Qihua Zhao Min Chen Zheng Feei Ma |
| author_sort | Hang Zhou |
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| description | Abstract Iron deficiency is prevalent among pregnant women because of the increased maternal iron requirements. Uncorrected maternal iron deficiency can lead to adverse neurodevelopmental outcomes in neonates. Therefore, the aim of this study was to assess serum ferritin concentration and prevalence of iron deficiency among pregnant women in Jiangsu, China. Within a cohort study, pregnant women were followed up from 2nd trimester of pregnancy until their labour. They were assessed for iron status in 2nd and 3rd trimesters using serum ferritin. In addition, neonatal APGAR score and birth weight were assessed in order to determine if maternal iron deficiency was associated with these neonatal outcomes. A total of 1688 pregnant women were followed up until their labour. The mean age of participants was 29 ± 4 years and 54.0% of them were multigravidas. Mean serum ferritin concentration in 2nd trimester was significantly higher than 3rd trimester (59.9 vs. 22.2 ng/mL) (P < 0.001). The prevalence of iron deficiency using serum ferritin concentration cut-off of < 15 ng/mL in 2nd and 3rd trimesters was 11.9% and 37.4%, respectively (P < 0.05). Maternal iron deficiency as assessed by serum ferritin concentration in 2nd and 3rd trimesters of pregnancy was not associated with neonatal outcomes (all P > 0.05). Our study reported that increased prevalence of maternal iron deficiency in 3rd trimester, suggesting that screening and supplementation of at-risk pregnancies can be used as a preventive strategy to tackle the issue. Consideration should be given to ensure adequate maternal iron status through pregnancy. |
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| institution | Kabale University |
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| language | English |
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| spelling | doaj-art-c4dea04787c648adb83dbba2caf0690c2025-01-12T12:21:03ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-024-80852-xMaternal iron deficiency assessed by serum ferritin and birth outcomes in mainland ChinaHang Zhou0Yiming Lu1Jianying Luo2Binyu Pan3Qihua Zhao4Min Chen5Zheng Feei Ma6Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityNorthern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityNorthern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityDepartment of Clinical Nutrition, Suzhou Ninth People’s HospitalNorthern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityHefei Preschool Education CollegeCentre for Public Health and Wellbeing, School of Health and Social Wellbeing, College of Health, Science and Society, University of the West of EnglandAbstract Iron deficiency is prevalent among pregnant women because of the increased maternal iron requirements. Uncorrected maternal iron deficiency can lead to adverse neurodevelopmental outcomes in neonates. Therefore, the aim of this study was to assess serum ferritin concentration and prevalence of iron deficiency among pregnant women in Jiangsu, China. Within a cohort study, pregnant women were followed up from 2nd trimester of pregnancy until their labour. They were assessed for iron status in 2nd and 3rd trimesters using serum ferritin. In addition, neonatal APGAR score and birth weight were assessed in order to determine if maternal iron deficiency was associated with these neonatal outcomes. A total of 1688 pregnant women were followed up until their labour. The mean age of participants was 29 ± 4 years and 54.0% of them were multigravidas. Mean serum ferritin concentration in 2nd trimester was significantly higher than 3rd trimester (59.9 vs. 22.2 ng/mL) (P < 0.001). The prevalence of iron deficiency using serum ferritin concentration cut-off of < 15 ng/mL in 2nd and 3rd trimesters was 11.9% and 37.4%, respectively (P < 0.05). Maternal iron deficiency as assessed by serum ferritin concentration in 2nd and 3rd trimesters of pregnancy was not associated with neonatal outcomes (all P > 0.05). Our study reported that increased prevalence of maternal iron deficiency in 3rd trimester, suggesting that screening and supplementation of at-risk pregnancies can be used as a preventive strategy to tackle the issue. Consideration should be given to ensure adequate maternal iron status through pregnancy.https://doi.org/10.1038/s41598-024-80852-xIron deficiencySerum ferritinHaemoglobinAnaemiaPregnant women |
| spellingShingle | Hang Zhou Yiming Lu Jianying Luo Binyu Pan Qihua Zhao Min Chen Zheng Feei Ma Maternal iron deficiency assessed by serum ferritin and birth outcomes in mainland China Scientific Reports Iron deficiency Serum ferritin Haemoglobin Anaemia Pregnant women |
| title | Maternal iron deficiency assessed by serum ferritin and birth outcomes in mainland China |
| title_full | Maternal iron deficiency assessed by serum ferritin and birth outcomes in mainland China |
| title_fullStr | Maternal iron deficiency assessed by serum ferritin and birth outcomes in mainland China |
| title_full_unstemmed | Maternal iron deficiency assessed by serum ferritin and birth outcomes in mainland China |
| title_short | Maternal iron deficiency assessed by serum ferritin and birth outcomes in mainland China |
| title_sort | maternal iron deficiency assessed by serum ferritin and birth outcomes in mainland china |
| topic | Iron deficiency Serum ferritin Haemoglobin Anaemia Pregnant women |
| url | https://doi.org/10.1038/s41598-024-80852-x |
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