A morphologically transformable hypoxia-induced radical anion for tumor-specific photothermal therapy
Tumor microenvironment activatable therapeutic agents and their effective tumor accumulation are significant for selective tumor treatment. Herein, we provide an unadulterated nanomaterial combining the above advantages. We synthesize a perylene diimide (PDI) molecule substituted by glutamic acid (G...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Acta Pharmaceutica Sinica B |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383524003824 |
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| author | Hongyu Wang Dengyuan Hao Qihang Wu Tingting Sun Zhigang Xie |
| author_facet | Hongyu Wang Dengyuan Hao Qihang Wu Tingting Sun Zhigang Xie |
| author_sort | Hongyu Wang |
| collection | DOAJ |
| description | Tumor microenvironment activatable therapeutic agents and their effective tumor accumulation are significant for selective tumor treatment. Herein, we provide an unadulterated nanomaterial combining the above advantages. We synthesize a perylene diimide (PDI) molecule substituted by glutamic acid (Glu), which can self-assemble into small spherical nanoparticles (PDI-SG) in aqueous solution. PDI-SG can not only be transformed into nanofibers at low pH conditions but also be reduced to PDI radical anion (PDI·‒), which exhibits strong near-infrared absorption and excellent photothermal performance. More importantly, PDI-SG can also be reduced to PDI·‒ in hypoxic tumors to ablate the tumors and minimize the damage to normal tissues. The morphological transformation from small nanoparticles to nanofibers makes for better tumor accumulation and retention. This work sheds light on the design of tumor microenvironment activatable therapeutics with precise structures for high-performance tumor therapy. |
| format | Article |
| id | doaj-art-c4d65a556ea441f5bae2b10d8590fa79 |
| institution | Kabale University |
| issn | 2211-3835 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj-art-c4d65a556ea441f5bae2b10d8590fa792024-12-18T08:48:46ZengElsevierActa Pharmaceutica Sinica B2211-38352024-12-01141254075417A morphologically transformable hypoxia-induced radical anion for tumor-specific photothermal therapyHongyu Wang0Dengyuan Hao1Qihang Wu2Tingting Sun3Zhigang Xie4State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, ChinaState Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, ChinaState Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, ChinaState Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; Corresponding authors.State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China; Corresponding authors.Tumor microenvironment activatable therapeutic agents and their effective tumor accumulation are significant for selective tumor treatment. Herein, we provide an unadulterated nanomaterial combining the above advantages. We synthesize a perylene diimide (PDI) molecule substituted by glutamic acid (Glu), which can self-assemble into small spherical nanoparticles (PDI-SG) in aqueous solution. PDI-SG can not only be transformed into nanofibers at low pH conditions but also be reduced to PDI radical anion (PDI·‒), which exhibits strong near-infrared absorption and excellent photothermal performance. More importantly, PDI-SG can also be reduced to PDI·‒ in hypoxic tumors to ablate the tumors and minimize the damage to normal tissues. The morphological transformation from small nanoparticles to nanofibers makes for better tumor accumulation and retention. This work sheds light on the design of tumor microenvironment activatable therapeutics with precise structures for high-performance tumor therapy.http://www.sciencedirect.com/science/article/pii/S2211383524003824Perylene diimideMorphological transformationRadical anionHypoxiaTumor-specificPhotothermal therapy |
| spellingShingle | Hongyu Wang Dengyuan Hao Qihang Wu Tingting Sun Zhigang Xie A morphologically transformable hypoxia-induced radical anion for tumor-specific photothermal therapy Acta Pharmaceutica Sinica B Perylene diimide Morphological transformation Radical anion Hypoxia Tumor-specific Photothermal therapy |
| title | A morphologically transformable hypoxia-induced radical anion for tumor-specific photothermal therapy |
| title_full | A morphologically transformable hypoxia-induced radical anion for tumor-specific photothermal therapy |
| title_fullStr | A morphologically transformable hypoxia-induced radical anion for tumor-specific photothermal therapy |
| title_full_unstemmed | A morphologically transformable hypoxia-induced radical anion for tumor-specific photothermal therapy |
| title_short | A morphologically transformable hypoxia-induced radical anion for tumor-specific photothermal therapy |
| title_sort | morphologically transformable hypoxia induced radical anion for tumor specific photothermal therapy |
| topic | Perylene diimide Morphological transformation Radical anion Hypoxia Tumor-specific Photothermal therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2211383524003824 |
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