Cardioprotective effects of total and anthocyanin-rich extracts of Opuntia ficus-indica fruit on epinephrine-induced cardiac injury in rats
Objective: To examine the effect of fruit extracts of Opuntia ficus-indica on epinephrine-induced myocardial injury in rats. Methods: Rats were pre-treated with hydroalcoholic and anthocyanin-rich extracts (250, 500, and 1 000 mg/kg) orally for 16 days. Epinephrine (2 mg/kg) was injected subcutaneou...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Asian Pacific Journal of Tropical Biomedicine |
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| Online Access: | https://journals.lww.com/10.4103/apjtb.apjtb_485_24 |
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| author | Leila Safaeian Masoud Sadeghi-Dinani Zahra Haghighatian Mohammad-Bagher Fatahian Marjan Khademizadeh |
| author_facet | Leila Safaeian Masoud Sadeghi-Dinani Zahra Haghighatian Mohammad-Bagher Fatahian Marjan Khademizadeh |
| author_sort | Leila Safaeian |
| collection | DOAJ |
| description | Objective:
To examine the effect of fruit extracts of Opuntia ficus-indica on epinephrine-induced myocardial injury in rats.
Methods:
Rats were pre-treated with hydroalcoholic and anthocyanin-rich extracts (250, 500, and 1 000 mg/kg) orally for 16 days. Epinephrine (2 mg/kg) was injected subcutaneously on days 15 and 16. Then ECG, heart rate, RR interval, cardiac histopathology, and serum parameters of cardiac damage and oxidative stress were evaluated.
Results:
Pretreatment with the hydroalcoholic and anthocyanin-rich extracts of Opuntia ficus-indica at doses of 500 and 1 000 mg/kg reversed epinephrine-induced changes in ECG, heart rate, RR interval, and cardiac histopathology, and attenuated creatine phosphokinase-MB activity and malondialdehyde level. The extracts at all doses diminished heart weight, lactate dehydrogenase, and aspartate aminotransferase, and also elevated total antioxidant capacity. However, 1 000 mg/kg of the anthocyanin-rich extract was more effective than the hydroalcoholic extract.
Conclusions:
Supplementation with fruit extracts of Opuntia ficus-indica, especially anthocyanin-rich extract, could protect against epinephrine-induced cardiac injury in rats by alleviating electrocardiographic, biochemical, histopathological, and oxidative stress parameters, and may be used in the treatment of cardiovascular diseases. |
| format | Article |
| id | doaj-art-c4d658c7808441fa9307305e64bf6fc7 |
| institution | Kabale University |
| issn | 2221-1691 2588-9222 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Biomedicine |
| spelling | doaj-art-c4d658c7808441fa9307305e64bf6fc72025-01-07T04:52:45ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912588-92222024-12-01141251452210.4103/apjtb.apjtb_485_24Cardioprotective effects of total and anthocyanin-rich extracts of Opuntia ficus-indica fruit on epinephrine-induced cardiac injury in ratsLeila SafaeianMasoud Sadeghi-DinaniZahra HaghighatianMohammad-Bagher FatahianMarjan KhademizadehObjective: To examine the effect of fruit extracts of Opuntia ficus-indica on epinephrine-induced myocardial injury in rats. Methods: Rats were pre-treated with hydroalcoholic and anthocyanin-rich extracts (250, 500, and 1 000 mg/kg) orally for 16 days. Epinephrine (2 mg/kg) was injected subcutaneously on days 15 and 16. Then ECG, heart rate, RR interval, cardiac histopathology, and serum parameters of cardiac damage and oxidative stress were evaluated. Results: Pretreatment with the hydroalcoholic and anthocyanin-rich extracts of Opuntia ficus-indica at doses of 500 and 1 000 mg/kg reversed epinephrine-induced changes in ECG, heart rate, RR interval, and cardiac histopathology, and attenuated creatine phosphokinase-MB activity and malondialdehyde level. The extracts at all doses diminished heart weight, lactate dehydrogenase, and aspartate aminotransferase, and also elevated total antioxidant capacity. However, 1 000 mg/kg of the anthocyanin-rich extract was more effective than the hydroalcoholic extract. Conclusions: Supplementation with fruit extracts of Opuntia ficus-indica, especially anthocyanin-rich extract, could protect against epinephrine-induced cardiac injury in rats by alleviating electrocardiographic, biochemical, histopathological, and oxidative stress parameters, and may be used in the treatment of cardiovascular diseases.https://journals.lww.com/10.4103/apjtb.apjtb_485_24opuntia ficus-indicaantioxidantcardiovascular diseasesepinephrinecardiac injurieslipid peroxidation |
| spellingShingle | Leila Safaeian Masoud Sadeghi-Dinani Zahra Haghighatian Mohammad-Bagher Fatahian Marjan Khademizadeh Cardioprotective effects of total and anthocyanin-rich extracts of Opuntia ficus-indica fruit on epinephrine-induced cardiac injury in rats Asian Pacific Journal of Tropical Biomedicine opuntia ficus-indica antioxidant cardiovascular diseases epinephrine cardiac injuries lipid peroxidation |
| title | Cardioprotective effects of total and anthocyanin-rich extracts of Opuntia ficus-indica fruit on epinephrine-induced cardiac injury in rats |
| title_full | Cardioprotective effects of total and anthocyanin-rich extracts of Opuntia ficus-indica fruit on epinephrine-induced cardiac injury in rats |
| title_fullStr | Cardioprotective effects of total and anthocyanin-rich extracts of Opuntia ficus-indica fruit on epinephrine-induced cardiac injury in rats |
| title_full_unstemmed | Cardioprotective effects of total and anthocyanin-rich extracts of Opuntia ficus-indica fruit on epinephrine-induced cardiac injury in rats |
| title_short | Cardioprotective effects of total and anthocyanin-rich extracts of Opuntia ficus-indica fruit on epinephrine-induced cardiac injury in rats |
| title_sort | cardioprotective effects of total and anthocyanin rich extracts of opuntia ficus indica fruit on epinephrine induced cardiac injury in rats |
| topic | opuntia ficus-indica antioxidant cardiovascular diseases epinephrine cardiac injuries lipid peroxidation |
| url | https://journals.lww.com/10.4103/apjtb.apjtb_485_24 |
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